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RECRUITING Phase 1

Phase 1a/1b First-in-Human Study of BG-C9074 Alone and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors

NCT06233942 · View on ClinicalTrials.gov ↗

Study Summary

This is a first-in-human, dose finding and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-C9074 alone and in combination with other anticancer therapies in patients with advanced solid tumors.

Conditions Studied

Interventions

  • DRUG Bevacizumab
  • DRUG Tislelizumab
  • DRUG BG-C9074

Study Locations (20)

Other

  • Hospital Sirio Libanes Brasilia — Brasília
  • Liga Norte Riograndene Contra O Cancer — Natal
  • Hospital Sao Lucas Da Pucrs — Porto Alegre
  • Instituto Nacional de Cancer Hospital Do Cancer Ii — Rio de Janerio
  • Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto — São José do Rio Preto
  • Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira — São Paulo
  • Clinica de Pesquisa E Centro de Estudos Em Oncologia Ginecologica E Mamaria — São Paulo

New South Wales

  • Blacktown Cancer and Haematology Centre — Blacktown
  • Macquarie University — North Ryde
  • Cancer Care Wollongong — Wollongong

Victoria

  • Monash Health — Clayton
  • Cabrini Hospital Malvern — Malvern East
  • Peter Maccallum Cancer Centre — Melbourne

California

  • Usc Norris Comprehensive Cancer Center (Nccc) — Los Angeles

Colorado

  • University of Colorado Cancer Center — Aurora

Florida

  • Florida Cancer Specialist Research Institute Lake Nona — Orlando

Maryland

  • Sidney Kimmel Comprehensive Cancer At Johns Hopkins — Baltimore

Ohio

  • James Cancer Hospital and Solove Research Institute — Columbus

Trial Details

FieldValue
Enrollment Target 308 participants
Start Date 2024-04-12
Est. Completion 2028-05-15
Phase Phase 1

Sponsor

BeOne Medicines

138 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06233942

The ClinicalTrials.gov registry entry for NCT06233942 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 308 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeOne Medicines, which has 138 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 3 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06233942 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Other, New South Wales, Victoria. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06233942 about?

NCT06233942 is a clinical study titled "Phase 1a/1b First-in-Human Study of BG-C9074 Alone and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors". This is a first-in-human, dose finding and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-C9074 alone and in combination with other anticancer therapies in patients with advanced solid tumors.

What is the current status of trial NCT06233942?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 308 participants. The study started on 2024-04-12. Estimated completion is 2028-05-15.

What conditions does trial NCT06233942 study?

This clinical trial studies the following conditions: Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06233942?

The interventions under investigation include: Bevacizumab (DRUG), Tislelizumab (DRUG), BG-C9074 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06233942?

This trial is sponsored by BeOne Medicines, which has 138 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06233942 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Maryland, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial