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A Study Evaluating ANV600 Single Agent or in Combination with Pembrolizumab in Participants with Advanced Solid Tumors (EXPAND-1)
NCT06470763 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of study ANV600-001 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, immunogenicity and antitumor activity of ANV600 administered as a single agent or in combination with pembrolizumab in adult participants with advanced solid tumors.
Conditions Studied
Interventions
- DRUG ANV600
- DRUG ANV600 + pembrolizumab (KEYTRUDA®)
Study Locations (18)
Other
- Cliniques Universitaires Saint-Luc — Brussels
- Institut Bergonie — Bordeaux
- CEPCM - AP-HM Hopital de la Timone — Marseille
- Oncopole Claudius Regaud, Toulouse — Toulouse
- Institut Gustave Roussy — Villejuif
- Charite Universitaetsmedizin Berlin — Berlin
- Krankenhaus Nordwest - Institut für Klinisch-Onkologische Forschung (IKF) — Frankfurt
- Universitaetsmedizin der Johannes Gutenberg - Universitaet Mainz — Mainz
- Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL) — Amsterdam
- Vall d'Hebron Institute of Oncology (VHIO) — Barcelona
- START Madrid CIOCC — Madrid
- Clinica Universidad de Navarra - Pamplona — Pamplona
- INCLIVA Foundation — Valencia
- Ente Ospedaliero Cantonale - Istituto Oncologico della Svizzera Italiana — Bellinzona
- Cantonal Hospital St Gallen — Sankt Gallen
Michigan
- Karmanos Cancer Institute — Detroit
Pennsylvania
- Fox Chase Cancer Center — Philadelphia
Texas
- MD Anderson Cancer Center — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2024-07-01 |
| Est. Completion | 2028-02 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06470763
The ClinicalTrials.gov registry entry for NCT06470763 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Anaveon, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 2 interventions — of which ANV600 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06470763 reports 18 study locations spanning 4 distinct geographic areas — top geographies include Other, Michigan, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06470763 about?
NCT06470763 is a clinical study titled "A Study Evaluating ANV600 Single Agent or in Combination with Pembrolizumab in Participants with Advanced Solid Tumors (EXPAND-1)". The purpose of study ANV600-001 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, immunogenicity and antitumor activity of ANV600 administered as a single agent or in combination with pembrolizumab in adult participants with advanced solid tumors.
What is the current status of trial NCT06470763?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 240 participants. The study started on 2024-07-01. Estimated completion is 2028-02.
What conditions does trial NCT06470763 study?
This clinical trial studies the following conditions: Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06470763?
The interventions under investigation include: ANV600 (DRUG), ANV600 + pembrolizumab (KEYTRUDA®) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06470763?
This trial is sponsored by Anaveon, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06470763 being conducted?
This trial has 18 study locations across Michigan, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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