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ClinicalTrials.gov 133 recruiting now official registry

Advanced Solid Tumor clinical trials

133 of 190 indexed Advanced Solid Tumor trials are currently recruiting.

190 US clinical trials · 133 currently recruiting

Advanced Solid Tumor is the subject of 190 registered US clinical trials on ClinicalTrials.gov, 133 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 186 in Phase 1-2 (earlier-stage). The most active sponsor is Daiichi Sankyo, running 7 of these trials.

The research picture

Advanced Solid Tumor has 190 registered US clinical trials, 133 of them open to new participants right now, about 70% of the total.

133
recruiting participants now
70%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
7
top sponsor: Daiichi Sankyo
Phase 1180Phase 26

Active & Recent Trials

190 total, page 2 of 4

RECRUITING Phase 1 200 participants

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

Volastra Therapeutics

NCT05902988

RECRUITING Phase 1 200 participants

SNV1521 in Participants with Advanced Solid Tumors

Synnovation Therapeutics

NCT06220864

RECRUITING Phase 1 192 participants

A Study of DS5361b in Participants With Advanced Solid Tumors

Daiichi Sankyo

NCT07182591

RECRUITING Phase 1 186 participants

SW-682 in Advanced Solid Tumors

SpringWorks Therapeutics

NCT06251310

RECRUITING Phase 1 178 participants

Study of GS-5319 in Adults With Solid Tumors

Gilead Sciences

NCT07128303

RECRUITING Phase 1 177 participants

JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

Jazz Pharmaceuticals

NCT06108050

RECRUITING Phase 1 175 participants

Study of LP-184 in Patients With Advanced Solid Tumors

Lantern Pharma

NCT05933265

RECRUITING Phase 1 168 participants

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

OncoResponse

NCT06090266

RECRUITING Phase 1 168 participants

A First-in-Human (FIH) Study of BG-C137, an Anti-Fibroblast Growth Factor Receptor 2b (FGFR2b) Antibody Drug Conjugate, in Participants With Advanced Solid Tumors

BeOne Medicines

NCT06625593

RECRUITING Phase 1 160 participants

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

CJ Bioscience

NCT05877430

RECRUITING Phase 1 159 participants

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Aulos Bioscience

NCT05267626

RECRUITING Phase 1 156 participants

A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors

Eikon Therapeutics

NCT06253130

RECRUITING Phase 1 155 participants

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

Plexium

NCT07284186

RECRUITING Phase 1 154 participants

A Study of CHS-114 in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

Coherus Oncology

NCT06657144

RECRUITING Phase 1 151 participants

A Phase I/II, Open-label Study to Investigate the Safety, Tolerability, PK, and Preliminary Efficacy of FB849

1ST Biotherapeutics

NCT05761223

RECRUITING Phase 1 150 participants

PM14 Administered Intravenously to Patients with Advanced Solid Tumors

PharmaMar

NCT05076396

RECRUITING Phase 1 150 participants

A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

NiKang Therapeutics

NCT06586957

RECRUITING Phase 1 150 participants

Efficacy and Safety Study of OMTX705, Monotherapy and Anti-PD-1-combined, in Subjects With Advanced Solid Tumors.

Oncomatryx Biopharma S.L.

NCT05547321

RECRUITING Phase 1 150 participants

A First-in-Human, Phase 1/2 Study of LAT010 in Patients With Advanced Solid Tumors (LIGHTSPEED-1)

Latticon Antibody Therapeutics

NCT06277219

RECRUITING Phase 1 147 participants

A Study Evaluating OBI-902 in Participants With Advanced Solid Tumors

OBI Pharma

NCT07124117

RECRUITING Phase 1 144 participants

EIS-12656 as Single Agent and in Combination in Patients With Specified Solid Tumors

Eisbach Bio

NCT06525298

RECRUITING Phase 2 141 participants

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

Day One Biopharmaceuticals

NCT04775485

RECRUITING Phase 1 140 participants

A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

Nuvectis Pharma

NCT05873686

RECRUITING Phase 1 136 participants

Vilastobart (XTX101) Monotherapy and Vilastobart and Atezolizumab Combination Therapy in Advanced Solid Tumors

Xilio Development

NCT04896697

RECRUITING Phase 1 132 participants

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

MOMA Therapeutics

NCT06974110

RECRUITING Phase 1 126 participants

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

7 Hills Pharma

NCT06362369

RECRUITING Phase 1 125 participants

Clinical Trial of PM54 in Advanced Solid Tumors Patients.

PharmaMar

NCT05841563

RECRUITING Phase 1 120 participants

A Study of NB004 as Monotherapy or Combination Therapy in Patients With Advanced Solid Tumors

Ningbo Newbay Technology Development Co.

NCT05036291

RECRUITING Phase 1 115 participants

A Beta-only IL-2 ImmunoTherapY Study

Medicenna Therapeutics

NCT05086692

RECRUITING Phase 1 112 participants

A Study of BTX-A51 in People With Advanced Solid Tumor and Breast Cancer

Edgewood Oncology

NCT04872166

RECRUITING Phase 1 110 participants

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

Alterome Therapeutics

NCT06533059

RECRUITING Phase 1 110 participants

Safety, Pharmacokinetics, and Clinical Activity of LP-284 in Adult Patients With Relapsed or Refractory Lymphomas and Solid Tumors

Lantern Pharma

NCT06132503

RECRUITING Phase 1 108 participants

Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

Strand Therapeutics

NCT06249048

RECRUITING Phase 1 105 participants

A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors

BeOne Medicines

NCT07226349

RECRUITING Phase 1 102 participants

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies

Ipsen

NCT07213830

RECRUITING Phase 1 101 participants

A Study of KK2269 in Adult Participants With Solid Tumors

Kyowa Kirin Co.

NCT06266299

RECRUITING Phase 1 100 participants

This is a Study to Evaluate the Safety and Tolerability of ABL503, and to Determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of ABL503 in Subjects with Any Progressive Locally Advanced or Metastatic Solid Tumors

ABL Bio

NCT04762641

RECRUITING Phase 1 100 participants

Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors

InSilico Medicine Hong Kong Limited

NCT06566079

RECRUITING Phase 1 97 participants

Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

Ankyra Therapeutics

NCT06171750

RECRUITING Phase 1 91 participants

64Cu-GRIP B in Patients With Advanced Malignancies

Rahul Aggarwal

NCT05888532

RECRUITING Phase 1 90 participants

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Clasp Therapeutics

NCT06778863

RECRUITING Phase 1 90 participants

A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab

Nectin Therapeutics

NCT05378425

RECRUITING Phase 1 90 participants

A Study of BGB-B455 in Adults With Advanced or Metastatic Solid Tumors

BeiGene

NCT06803680

RECRUITING Phase 1 90 participants

Study of APR-1051 in Patients With Advanced Solid Tumors

Aprea Therapeutics

NCT06260514

RECRUITING Phase 1 90 participants

First in Human Study of TORL-1-23 in Participants With Advanced Cancer

TORL Biotherapeutics

NCT05103683

RECRUITING Phase 1 87 participants

Study of BG-T187 Alone and in Combination With Other Therapeutic Agents in Participants With Advanced Solid Tumors

BeiGene

NCT06598800

RECRUITING Phase 1 87 participants

Study of CHS-114 in Participants With Advanced Solid Tumors

Coherus Oncology

NCT05635643

RECRUITING Phase 1 86 participants

CLN-617 Alone and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

Cullinan Therapeutics

NCT06035744

RECRUITING Phase 1 86 participants

An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors

BeOne Medicines

NCT07222267

RECRUITING Phase 1 85 participants

A Study to Assess a New Medicine Called IPN01195 When Administered Alone in Adults With Advanced Solid Tumours

Ipsen

NCT06833008

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Phase Distribution

PhaseTrial count
Phase 1 180
Phase 2 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Solid Tumor Trial Landscape

190 indexed Advanced Solid Tumor studies · 133 recruiting (70%).

Phase mix: 0 late (III/IV) vs 186 early (I/II).

Top sponsor: Daiichi Sankyo (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Solid Tumor?

PlainTrial tracks 190 US clinical trials for Advanced Solid Tumor, of which 133 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Solid Tumor?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.