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RECRUITING Phase 1

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

NCT04104776 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this open-label, first-in-human (FIH) trial is to evaluate the safety, tolerability, and preliminary clinical activity of Tulmimetostat as a monotherapy in patients with advanced solid tumors and lymphomas.

Interventions

  • DRUG Enzalutamide
  • DRUG Tulmimetostat

Study Locations (20)

New York

  • NYU Langone Medical Center - Laura and Isaac Perlmutter Cancer Center — New York
  • Weill Medical College of Cornell University — New York
  • Montefiore Einstein Center for Cancer Care — The Bronx

Other

  • Bergonie Institute — Bordeaux
  • Oscar Lambret Center — Lille
  • Leon Berard Center — Lyon

Massachusetts

  • Massachusetts General Hospital — Boston
  • Dana Farber Cancer Institute — Boston

Michigan

  • University of Michigan Hospital — Ann Arbor
  • South Texas Accelerated Research Therapeutics (Start) - Midwest Location — Grand Rapids

Washington

  • Swedish Cancer Institute — Seattle
  • Fred Hutchinson Cancer — Seattle

Georgia

  • Winship Cancer Institute of Emory University — Atlanta

Illinois

  • University of Chicago Medical Center — Chicago

Maryland

  • University of Maryland - Marlene and Stewart Greenebaum Cancer Center — Baltimore

Trial Details

FieldValue
Enrollment Target 275 participants
Start Date 2019-09-18
Est. Completion 2030-02-27
Phase Phase 1

Sponsor

Novartis Pharmaceuticals

792 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04104776

The ClinicalTrials.gov registry entry for NCT04104776 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 275 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novartis Pharmaceuticals, which has 792 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 8 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 2 interventions — of which Enzalutamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04104776 reports 20 study locations spanning 13 distinct geographic areas — top geographies include New York, Other, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04104776 about?

NCT04104776 is a clinical study titled "A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas". The purpose of this open-label, first-in-human (FIH) trial is to evaluate the safety, tolerability, and preliminary clinical activity of Tulmimetostat as a monotherapy in patients with advanced solid tumors and lymphomas.

What is the current status of trial NCT04104776?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 275 participants. The study started on 2019-09-18. Estimated completion is 2030-02-27.

What conditions does trial NCT04104776 study?

This clinical trial studies the following conditions: Advanced Solid Tumor, Endometrial Cancer, Metastatic Castration-resistant Prostate Cancer, Diffuse Large B Cell Lymphoma, Prostatic Neoplasms, Castration-Resistant. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04104776?

The interventions under investigation include: Enzalutamide (DRUG), Tulmimetostat (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04104776?

This trial is sponsored by Novartis Pharmaceuticals, which has 792 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04104776 being conducted?

This trial has 20 study locations across Georgia, Illinois, Maryland, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial