Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

NCT05098132 · View on ClinicalTrials.gov ↗

Study Summary

This is a phase 1/2, multicenter, open-label study. The phase 1 portion is a dose escalation and expansion study of STK-012 as monotherapy and in combination therapy in patients with selected advanced solid tumors. The phase 2 portion is a randomized study of STK-012 in combination with standard of care (SoC) pembrolizumab, pemetrexed, and carboplatin versus SoC, in patients with first line, PD-L1 negative, non-squamous, non-small cell lung cancer.

Interventions

  • DRUG pembrolizumab
  • DRUG carboplatin
  • DRUG STK-012
  • DRUG pemetrexed

Study Locations (20)

California

  • Beverly Hills Cancer Center — Beverly Hills
  • Providence Medical Foundation — Fullerton
  • UC San Diego Moores Cancer Center — La Jolla
  • Hoag Memorial Hospital Presbyterian — Newport Beach
  • UCLA Hematology/Oncology - Santa Monica — Santa Monica

New York

  • Northwell Health — Lake Success
  • NYU Langone Health — New York
  • Columbia University Irving Medical Center — New York
  • Memorial Sloan-Kettering Cancer Center — New York

Massachusetts

  • Massachusetts General Hospital — Boston
  • Beth Israel Deaconess Medical Center — Boston
  • Dana-Farber Cancer Institute — Boston

Arizona

  • University of Arizona Cancer Center — Tucson

Connecticut

  • Yale New Haven Hospital, Yale Cancer Center — New Haven

District of Columbia

  • Georgetown University — Washington D.C.

Georgia

  • Winship Cancer Institute, Emory University — Atlanta

Minnesota

  • HealthPartners Cancer Center at Regions Hospital — Saint Paul

Trial Details

FieldValue
Enrollment Target 364 participants
Start Date 2022-01-25
Est. Completion 2029-01
Phase Phase 1

Sponsor

Synthekine

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05098132

The ClinicalTrials.gov registry entry for NCT05098132 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 364 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Synthekine, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 4 interventions — of which pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05098132 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, New York, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05098132 about?

NCT05098132 is a clinical study titled "Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers". This is a phase 1/2, multicenter, open-label study. The phase 1 portion is a dose escalation and expansion study of STK-012 as monotherapy and in combination therapy in patients with selected advanced solid tumors. The phase 2 portion is a randomized study of STK-012 in combination with standard of ...

What is the current status of trial NCT05098132?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 364 participants. The study started on 2022-01-25. Estimated completion is 2029-01.

What conditions does trial NCT05098132 study?

This clinical trial studies the following conditions: Advanced Solid Tumor, Non Small Cell Lung Cancer, Untreated Advanced NSCLC, 1st Line NSCLC. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05098132?

The interventions under investigation include: pembrolizumab (DRUG), carboplatin (DRUG), STK-012 (DRUG), pemetrexed (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05098132?

This trial is sponsored by Synthekine, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05098132 being conducted?

This trial has 20 study locations across Arizona, California, Connecticut, District of Columbia, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial