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A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors
NCT06997029 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to assess BMS-986500 as monotherapy in advanced solid tumors and as combination therapy in CDK4/6 inhibitor pre-treated advanced breast cancer.
Conditions Studied
Interventions
- DRUG Fulvestrant
- DRUG Palbociclib
- DRUG BMS-986500
Study Locations (20)
California
- Providence St. Jude Medical Center — Fullerton
- Marin Cancer Care — Greenbrae
- Moores Cancer Center — La Jolla
- Hoag Memorial Hospital Presbyterian — Newport Beach
New York
- Local Institution - 0014 — Buffalo
- Northwell Health-Cancer Institute — New Hyde Park
- Local Institution - 0011 — New York
- Memorial Sloan Kettering Cancer Center — New York
Texas
- START Dallas Fort Worth — Fort Worth
- NEXT Oncology — San Antonio
Alabama
- University of Alabama at Birmingham — Birmingham
Colorado
- Local Institution - 0008 — Aurora
Massachusetts
- Dana-Farber Cancer Institute — Boston
Missouri
- Washington University School of Medicine — St Louis
New Hampshire
- Dartmouth-Hitchcock Medical Center — Lebanon
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 234 participants |
| Start Date | 2025-08-01 |
| Est. Completion | 2028-12-14 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06997029
The ClinicalTrials.gov registry entry for NCT06997029 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 234 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bristol-Myers Squibb, which has 504 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 3 interventions — of which Fulvestrant is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06997029 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, New York, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06997029 about?
NCT06997029 is a clinical study titled "A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors". The purpose of this study is to assess BMS-986500 as monotherapy in advanced solid tumors and as combination therapy in CDK4/6 inhibitor pre-treated advanced breast cancer.
What is the current status of trial NCT06997029?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 234 participants. The study started on 2025-08-01. Estimated completion is 2028-12-14.
What conditions does trial NCT06997029 study?
This clinical trial studies the following conditions: Advanced Solid Tumor, Advanced Breast Cancer, Advanced Ovarian Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06997029?
The interventions under investigation include: Fulvestrant (DRUG), Palbociclib (DRUG), BMS-986500 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06997029?
This trial is sponsored by Bristol-Myers Squibb, which has 504 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06997029 being conducted?
This trial has 20 study locations across Alabama, California, Colorado, Massachusetts, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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