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NCT07300943 · ClinicalTrials.gov registry record · Phase 1
Study in Advanced Solid Tumor Patients
A Phase 1 study of Advanced Solid Tumor, sponsored by Callio Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 306
- Enrollment target
- 11
- Study locations
NCT07300943: Recruiting Phase 1 study of Advanced Solid Tumor, sponsored by Callio Therapeutics.
NCT07300943 is a Phase 1 study of Advanced Solid Tumor that is actively recruiting participants, run by Callio Therapeutics. The registered enrollment target is 306 participants, above the 191-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (60% higher). The trial reports 11 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07300943, a Phase 1 study of Advanced Solid Tumor, is actively recruiting participants, sponsored by Callio Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 306 participants
- Enrollment target
- 11
- Study locations
Study Summary
The study will be conducted in 2 phases: Phase 1: Dose-escalation and Dose Level Expansion, Phase 1 will determine the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE). Phase 2: Tumor-Specific Expansions with Dose Optimization, Phase 2 will further evaluate CLIO-8221 in tumor-specific expansion cohorts to optimize dosing and assess preliminary efficacy.
Primary Outcome
Type, incidence, severity, and seriousness of AEs occurred
Conditions Studied
Interventions
- DRUG CLIO-8221
Study Locations (11)
Victoria
- Peter Maccallum Cancer Centre - Box Hill
- AlfredHealth - Heidelberg
- Royal Melbourne Hospital - Melbourne
Texas
- MD Anderson Cancer Center - Houston
- START San Antonio - San Antonio
Massachusetts
- DFCI - Boston
Tennessee
- Sarah Cannon Research Institute 335 24th Avenue North, Suite 400 - Nashville
Utah
- START Mountain - West Valley City
New South Wales
- Scientia Clinical Research - Randwick
Queensland
- Integrated Clinical Oncology Network Pty Ltd - South Brisbane
Western Australia
- Linear Clinical Research Ltd - Nedlands
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 306 participants |
| Start Date | 2026-02-28 |
| Est. Completion | 2028-07-17 |
| Phase | Phase 1 |
What NCT07300943 shows while recruiting
NCT07300943 is an interventional study that assigns participants to a tested intervention. The registered 306 participants enrollment target is mid-sized for trials with a published cap, above the 191-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (60% higher).
The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 1 intervention - of which CLIO-8221 is the first listed.
NCT07300943 lists 11 locations in 8 states (Victoria, Texas, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT07300943 about?
NCT07300943 is a clinical study titled "Study in Advanced Solid Tumor Patients". The study will be conducted in 2 phases: Phase 1: Dose-escalation and Dose Level Expansion, Phase 1 will determine the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE). Phase 2: Tumor-Specific Expansions with Dose Optimization, Phase 2 will further evaluate CLIO-8221 in tumor...
What is the current status of trial NCT07300943?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 306 participants. The study started on 2026-02-28. Estimated completion is 2028-07-17.
What conditions does trial NCT07300943 study?
This clinical trial studies the following conditions: Advanced Solid Tumor.
What interventions are being tested in trial NCT07300943?
The interventions under investigation include: CLIO-8221 (DRUG).
Who is sponsoring clinical trial NCT07300943?
This trial is sponsored by Callio Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07300943 being conducted?
This trial has 11 study locations across Massachusetts, Tennessee, Texas, Utah, New South Wales. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Advanced Solid Tumor
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07300943's enrollment target sits among peer trials
306 37th of 189 higher than 153 of 189 other Advanced Solid Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Advanced Solid Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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