Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Study in Advanced Solid Tumor Patients

NCT07300943 · View on ClinicalTrials.gov ↗

Study Summary

The study will be conducted in 2 phases: Phase 1: Dose-escalation and Dose Level Expansion, Phase 1 will determine the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE). Phase 2: Tumor-Specific Expansions with Dose Optimization, Phase 2 will further evaluate CLIO-8221 in tumor-specific expansion cohorts to optimize dosing and assess preliminary efficacy.

Conditions Studied

Interventions

  • DRUG CLIO-8221

Study Locations (11)

Victoria

  • Peter Maccallum Cancer Centre — Box Hill
  • AlfredHealth — Heidelberg
  • Royal Melbourne Hospital — Melbourne

Texas

  • MD Anderson Cancer Center — Houston
  • START San Antonio — San Antonio

Massachusetts

  • DFCI — Boston

Tennessee

  • Sarah Cannon Research Institute 335 24th Avenue North, Suite 400 — Nashville

Utah

  • START Mountain — West Valley City

New South Wales

  • Scientia Clinical Research — Randwick

Queensland

  • Integrated Clinical Oncology Network Pty Ltd — South Brisbane

Western Australia

  • Linear Clinical Research Ltd — Nedlands

Trial Details

FieldValue
Enrollment Target 306 participants
Start Date 2026-02-28
Est. Completion 2028-07-17
Phase Phase 1

Sponsor

Callio Therapeutics

1 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07300943

The ClinicalTrials.gov registry entry for NCT07300943 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 306 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Callio Therapeutics, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 1 intervention — of which CLIO-8221 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07300943 reports 11 study locations spanning 8 distinct geographic areas — top geographies include Victoria, Texas, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07300943 about?

NCT07300943 is a clinical study titled "Study in Advanced Solid Tumor Patients". The study will be conducted in 2 phases: Phase 1: Dose-escalation and Dose Level Expansion, Phase 1 will determine the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE). Phase 2: Tumor-Specific Expansions with Dose Optimization, Phase 2 will further evaluate CLIO-8221 in tumor...

What is the current status of trial NCT07300943?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 306 participants. The study started on 2026-02-28. Estimated completion is 2028-07-17.

What conditions does trial NCT07300943 study?

This clinical trial studies the following conditions: Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07300943?

The interventions under investigation include: CLIO-8221 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07300943?

This trial is sponsored by Callio Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07300943 being conducted?

This trial has 11 study locations across Massachusetts, Tennessee, Texas, Utah, New South Wales. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial