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A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors
NCT06561685 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of this study is to find out whether the study drug, LY4050784, is safe, tolerable and effective in participants alone or in combination with other anticancer agents. In addition, with locally advanced or metastatic solid tumors with a BRG1 (Brahma-related gene 1, also known as SMARCA4) alteration who have previously received, do not qualify for, or are refusing standard of care treatments, or there is no standard therapy available for the disease. The study is conducted in two parts - phase Ia (dose-escalation) and phase Ib (dose-optimization, dose-expansion). The study will last up to approximately 4 years.
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Carboplatin
- DRUG Cisplatin
- DRUG Pemetrexed
- DRUG LY4050784
Study Locations (20)
Tennessee
- Sarah Cannon Research Institute — Nashville
- SCRI Oncology Partners — Nashville
- Vanderbilt-Ingram Cancer Center — Nashville
Other
- Institut Bergonie — Bordeaux
- Institut Curie — Paris
- Institut Gustave Roussy-Gustave Roussy Cancer Center -DITEP — Villejuif
Colorado
- University of Colorado Health Hospital — Aurora
- Sarah Cannon Research Institute at HealthOne — Denver
Florida
- Florida Cancer Specialists ORLANDO/DDU — Lake Mary
- University of Miami — Miami
Massachusetts
- Massachusetts General Hospital — Boston
- Dana-Farber Cancer Institute — Boston
New York
- Columbia University Medical Center — New York
- Memorial Sloan Kettering Cancer Center — New York
California
- UCLA — Santa Monica
Illinois
- University of Chicago — New Lenox
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 340 participants |
| Start Date | 2024-09-19 |
| Est. Completion | 2027-10 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06561685
The ClinicalTrials.gov registry entry for NCT06561685 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 340 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06561685 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Tennessee, Other, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06561685 about?
NCT06561685 is a clinical study titled "A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors". The main purpose of this study is to find out whether the study drug, LY4050784, is safe, tolerable and effective in participants alone or in combination with other anticancer agents. In addition, with locally advanced or metastatic solid tumors with a BRG1 (Brahma-related gene 1, also known as SMAR...
What is the current status of trial NCT06561685?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 340 participants. The study started on 2024-09-19. Estimated completion is 2027-10.
What conditions does trial NCT06561685 study?
This clinical trial studies the following conditions: Advanced Solid Tumor, Non-small Cell Lung Cancer, Metastatic Solid Tumor, SMARCA4-Deficient Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06561685?
The interventions under investigation include: Pembrolizumab (DRUG), Carboplatin (DRUG), Cisplatin (DRUG), Pemetrexed (DRUG), LY4050784 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06561685?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06561685 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Illinois, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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