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An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors
NCT06589596 · View on ClinicalTrials.gov ↗
Study Summary
This is an open-label, multicenter, first-in-human dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BGB-58067 alone, in combination with BG-89894, and in combination with standard of care therapy in participants with advanced solid tumors and with methylthioadenosine phosphorylase (MTAP) deficiency.
Conditions Studied
Interventions
- DRUG BG-89894
- DRUG BGB-58067
- DRUG Standard of Care Therapy
Study Locations (20)
Beijing Municipality
- Cancer Hospital Chinese Academy of Medical Sciences — Beijing
- Beijing Cancer Hospital — Beijing
- Beijing Chest Hospital, Capital Medical University — Beijing
Texas
- The University of Texas Md Anderson Cancer Center — Houston
- Next Dallas — Irving
Victoria
- Monash Health — Clayton
- Austin Health — Heidelberg
California
- Usc Norris Comprehensive Cancer Center (Nccc) — Los Angeles
Florida
- Adventhealth — Celebration
Massachusetts
- Dana Farber Cancer Institute — Boston
Missouri
- Washington University School of Medicine — St Louis
New York
- Nyu Langone Health — New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 244 participants |
| Start Date | 2024-10-11 |
| Est. Completion | 2029-01 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06589596
The ClinicalTrials.gov registry entry for NCT06589596 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 244 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeOne Medicines, which has 138 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 3 interventions — of which BG-89894 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06589596 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Beijing Municipality, Texas, Victoria. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06589596 about?
NCT06589596 is a clinical study titled "An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors". This is an open-label, multicenter, first-in-human dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BGB-58067 alone, in combination with BG-89894, and in combination with standard of care therapy ...
What is the current status of trial NCT06589596?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 244 participants. The study started on 2024-10-11. Estimated completion is 2029-01.
What conditions does trial NCT06589596 study?
This clinical trial studies the following conditions: Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06589596?
The interventions under investigation include: BG-89894 (DRUG), BGB-58067 (DRUG), Standard of Care Therapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06589596?
This trial is sponsored by BeOne Medicines, which has 138 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06589596 being conducted?
This trial has 20 study locations across California, Florida, Massachusetts, Missouri, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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