Daiichi Sankyo

157 total trials 91 currently recruiting 48 completed

Trial Pipeline

RECRUITING Phase 1

A First-in-Human Trial of DS3790a in Participants With Hematological Malignancies

NCT07220616

RECRUITING Phase 1

A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC)

NCT07244341

RECRUITING Phase 1

A Study of DS9051b in Participants With Advanced or Metastatic Adrenocortical Carcinoma and Metastatic Castration-resistant Prostate Cancer

NCT07189403

RECRUITING Phase 3

Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

NCT06899126

RECRUITING Phase 1

A Study of DS5361b in Participants With Advanced Solid Tumors

NCT07182591

RECRUITING Phase 3

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

NCT07022483

RECRUITING Phase 2

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

NCT07129993

RECRUITING Phase 2

Evaluation of Two Dose Levels of Quizartinib as Maintenance in FLT3-ITD (+) Acute Myeloid Leukemia Patients in Complete Remission

NCT06824168

RECRUITING Phase 1

A Study of Subcutaneous Trastuzumab Deruxtecan in Participants With Metastatic Solid Tumors

NCT07015697

RECRUITING Phase 3

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

NCT06644781

RECRUITING Phase 3

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

NCT06819007

RECRUITING Phase 3

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

NCT06731478

RECRUITING Phase 2

A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01)

NCT06660654

RECRUITING Phase 3

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

NCT06578247

RECRUITING Phase 1

First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors

NCT06644755

RECRUITING Phase 1

A Study of Valemetostat Tosylate Plus Pembrolizumab Versus Pembrolizumab Alone in First-Line NSCLC Without Actionable Genomic Alterations

NCT06644768

RECRUITING Phase 1

Assessment of Quizartinib Pharmacokinetic in Subjects With Severe Hepatic Impairment

NCT06740799

RECRUITING Phase 1

A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)

NCT06362252

RECRUITING Phase 3

A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

NCT06203210

RECRUITING Phase 2

A Study To Evaluate The Efficacy And Safety Of Ifinatamab Deruxtecan (I-DXd) In Subjects With Recurrent Or Metastatic Solid Tumors (IDeate-PanTumor02)

NCT06330064

RECRUITING Phase 2

A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

NCT06161025

RECRUITING Phase 2

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

NCT06172478

RECRUITING Phase 1

A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors

NCT06244485

RECRUITING Phase 3

A Study to Provide Continued Access to and Assess Long-Term Safety of the Study Drug(s)

NCT06174987

RECRUITING Phase 3

Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

NCT05950945

RECRUITING Phase 1

First-in-Human Study of DS-3939a in Participants With Advanced Solid Tumors

NCT05875168

RECRUITING Phase 3

Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations

NCT05215340

RECRUITING

A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) Treatment

NCT04635111

RECRUITING Phase 1

Study of Ifinatamab Deruxtecan (DS-7300a, I-DXd) in Participants With Advanced Solid Malignant Tumors

NCT04145622

ACTIVE NOT RECRUITING

Patterns of Care and Outcomes in Locally Recurrent Inoperable or Metastatic Triple-Negative Breast Cancer

NCT07092254

ACTIVE NOT RECRUITING Phase 1

A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors

NCT05765851

ACTIVE NOT RECRUITING Phase 3

Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)

NCT05555732

ACTIVE NOT RECRUITING Phase 3

HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy

NCT05338970

ACTIVE NOT RECRUITING Phase 2

Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

NCT05280470

ACTIVE NOT RECRUITING Phase 1

HER3-DXd (Patritumab Deruxtecan; U3-1402) in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic EGFR-mutated Non-Small Cell Lung Cancer

NCT04676477

ACTIVE NOT RECRUITING Phase 2

Valemetostat Tosylate (DS-3201b), an Enhancer of Zeste Homolog (EZH) 1/2 Dual Inhibitor, for Relapsed/Refractory Peripheral T-Cell Lymphoma (VALENTINE-PTCL01)

NCT04703192

ACTIVE NOT RECRUITING Phase 2

HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

NCT04619004

ACTIVE NOT RECRUITING Phase 1

A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors

NCT04707248

ACTIVE NOT RECRUITING Phase 3

Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)

NCT04656652

ACTIVE NOT RECRUITING Phase 3

A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

NCT04622319

ACTIVE NOT RECRUITING Phase 1

A Study Evaluating DS-1055a in Participants With Relapsed or Refractory Locally Advanced or Metastatic Solid Tumors

NCT04419532

ACTIVE NOT RECRUITING Phase 1

Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02)

NCT04526691

ACTIVE NOT RECRUITING Phase 1

DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer

NCT04042701

ACTIVE NOT RECRUITING Phase 3

Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]

NCT03734029

ACTIVE NOT RECRUITING Phase 1

Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood

NCT03793478

ACTIVE NOT RECRUITING Phase 3

DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03]

NCT03529110

ACTIVE NOT RECRUITING Phase 1

U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer

NCT03260491

COMPLETED

A Study Assessing Risk Factors for Oral Mucositis/Stomatitis and Ocular Surface Events in NSCLC and Breast Cancer

NCT06686602

COMPLETED

Study on Prevalence and Impact of Brain Metastases on Survival in Lung Cancer by Line of Treatment

NCT06557967

COMPLETED Phase 2

A Study of DS-1211b in Individuals With PseudoXanthoma Elasticum

NCT05569252

COMPLETED Phase 1

A Study of a Single Ascending Dose Study of DS-7011a in Healthy Subjects

NCT05203692

COMPLETED Phase 1

Study of Single-dose DS-3201b in Participants With Hepatic Impairment

NCT04276662

COMPLETED Early Phase 1

Pharmacokinetics (PK) Drug Interaction Study of Milademetan and Itraconazole or Posaconazole in Healthy Participants

NCT03614455

COMPLETED Phase 1

Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics)

NCT03291288

COMPLETED

Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project

NCT02948088

COMPLETED Phase 1

A Study to Determine the Effects of Itraconazole on the Pharmacokinetics (PK) of DS-8500 in Healthy Subjects

NCT02790671

COMPLETED Phase 1

The Effect of CS-3150 Exposure on Corrected QT (QTc) Interval Duration in Healthy Volunteers

NCT04019652

COMPLETED Phase 1

Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of DS-1040b in Subjects With Acute Ischemic Stroke

NCT02586233

COMPLETED Phase 3

Cancer Venous Thromboembolism (VTE)

NCT02073682

COMPLETED Phase 3

Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)

NCT02371369

COMPLETED Phase 1

Phase 1 Pediatric Pharmacokinetics/Pharmacodynamics (PK/PD) Study

NCT02303431

COMPLETED Phase 1

A Phase 1b/2 Study of PLX3397 + Radiation Therapy + Temozolomide in Patients With Newly Diagnosed Glioblastoma

NCT01790503

COMPLETED Phase 1

Study to Assess Pharmacokinetics, Immunogenicity and Safety/Tolerability of Patritumab (U3-1287)

NCT01957280

COMPLETED Phase 2

Edoxaban in Peripheral Arterial Disease

NCT01802775

COMPLETED Phase 3

Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma (HCC) Who Have Been Treated With One Prior Therapy

NCT01755767

COMPLETED Phase 2

Treatment of Neuropathic Pain Associated With Diabetic Peripheral Neuropathy

NCT01496365

COMPLETED Phase 4

Colesevelam for Children With Type 2 Diabetes

NCT01258075

COMPLETED Phase 2

CS1008- in Combination With Sorafenib Compared to Sorafenib Alone in Subjects With Advanced Liver Cancer

NCT01033240

COMPLETED Phase 1

Determination of the Relative Bioavailability of ARQ 197 Tablet Formulation With Capsule C Formulation as a Reference in Subjects With Advanced Solid Tumors

NCT01149720

COMPLETED Phase 1

Dose Finding, Safety and Tolerability Study for AC220 to Treat Advanced Solid Tumors

NCT01049893

COMPLETED Phase 2

Study of CS-7017 in Combination With FOLFIRI in Subjects With Metastatic Colorectal Cancer Who Failed First-Line Therapy

NCT00967616

COMPLETED Phase 4

Olmesartan Comparison to Losartan in Hypertensive Subjects

NCT00949884

COMPLETED Phase 3

Welchol as Monotherapy for Type 2 Diabetes Mellitus

NCT00789737

COMPLETED Phase 1

12-week Safety Evaluation of Oral CS-0777 in Multiple Sclerosis Patients

NCT00616733

COMPLETED Phase 1

Effects of CS-8080 in Healthy Volunteers

NCT00613431

COMPLETED Phase 2

Open-label Study of CS-1008 for Subjects With Untreated and Unresectable Pancreatic Cancer

NCT00521404

COMPLETED Phase 2

Preliminary Study of Piclozotan in Patients With Motor Complications Associated With Parkinson's Disease

NCT00623363

COMPLETED Phase 3

Effects of Colesevelam HCl, Rosiglitazone, Sitagliptin on Control of Blood Glucose and Lipids in Type 2 Diabetes Patients Whose Blood Glucose Isn't Completely Controlled With Metformin

NCT00484419

COMPLETED Phase 3

Study of Rivoglitazone in Type 2 Diabetes Mellitus

NCT00484198

COMPLETED Phase 4

A Study of the Blood Pressure Lowering Ability and Safety of Olmesartan Medoxomil in Stage I and Stage II Hypertension

NCT00430638

COMPLETED Phase 1

Study of an Experimental New Drug, PPARγ Agonist Taken by Mouth by Participants With Advanced or Metastatic Cancer

NCT00408434

COMPLETED Phase 2

A Study of DU-176b in Preventing Blood Clots After Hip Replacement Surgery

NCT00398216

COMPLETED Phase 2

Effects on Colesevelam HC1 (WelChol®) on Insulin Sensitivity in Subjects With Type 2 Diabetes Mellitus

NCT00361153

COMPLETED Phase 2

Evaluation of Glucose Lowering Effect, Safety and Tolerability of CS-917

NCT00290940

COMPLETED Phase 1

Olmesartan Pediatric Pharmacokinetic (PK) Study

NCT00151814

COMPLETED Phase 3

WelChol® With Metformin in Treating Patients With Type 2 Diabetes

NCT00147719

COMPLETED Phase 4

An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With Hypertension

NCT00185068

COMPLETED Phase 4

A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin

NCT00185094

COMPLETED Phase 4

Study to Compare Welchol and TriCor to TriCor Alone in Patients With High Cholesterol

NCT00754039

COMPLETED Phase 2

Efficacy and Safety of the ACAT Inhibitor CS-505 (Pactimibe) for Reducing the Progression of Coronary Artery Disease

NCT00185042

COMPLETED Phase 4

A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Simvastatin for at Least 4 Weeks.

NCT00753779

COMPLETED Phase 2

DX-8951f in Treating Patients With Metastatic Stomach Cancer

NCT00017212

COMPLETED Phase 2

DX-8951f in Treating Patients With Biliary Cancer

NCT00005938

COMPLETED Phase 2

DX-8951f in Treating Patients With Liver Cancer

NCT00004108

COMPLETED Phase 2

Chemotherapy in Treating Women With Metastatic Breast Cancer

NCT00004046

Phase Distribution

PhaseTrial count
Phase 1 36
Phase 2 86
Phase 3 23
Phase 4 7

What the Pipeline for Daiichi Sankyo Shows

According to the ClinicalTrials.gov registry, Daiichi Sankyo is linked to 157 US clinical trials across every stage of research activity. Of those, 91 studies are currently recruiting — about 58% of the sponsor's indexed portfolio — and 48 are already marked complete, representing roughly 31% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for Daiichi Sankyo reports 30 late-stage studies (Phase 3 and Phase 4 combined) and 122 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for Daiichi Sankyo is Advanced Solid Tumor with 7 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial