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RECRUITING Phase 1

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

NCT06465069 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to find out whether the study drug, LY4052031, is safe, tolerable and effective in participants with advanced, or metastatic solid tumors including urothelial cancer. The study is conducted in two parts - phase Ia (dose-escalation, dose-optimization) and phase Ib (dose-expansion). The study will last up to approximately 4 years.

Interventions

  • DRUG LY4052031

Study Locations (20)

Other

  • St Vincent's Hospital — Darlinghurst
  • Linear Clinical Research — Nedlands
  • Institut Gustave Roussy (Igr) — Villejuif
  • National Cancer Center Hospital East — Kashiwa, Chiba
  • The Cancer Institute Hospital of JFCR — Kōtō City

New York

  • Icahn School of Medicine at Mount Sinai — New York
  • Columbia University Irving Medical Center — New York
  • Memorial Sloan Kettering Cancer Center — New York

Texas

  • University of Texas MD Anderson Cancer Center — Houston
  • South Texas Accelerated Research Therapeutics (START) — San Antonio

Utah

  • University of Utah - Huntsman Cancer Institute — Salt Lake City
  • START Mountain Region — West Valley City

California

  • City of Hope National Medical Center — Duarte

Colorado

  • Sarah Cannon Research Institute at HealthOne — Denver

Florida

  • Florida Cancer Specialists and Research Institute — St. Petersburg

Illinois

  • University of Chicago Hospital — Chicago

Trial Details

FieldValue
Enrollment Target 420 participants
Start Date 2024-07-01
Est. Completion 2027-05
Phase Phase 1

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06465069

The ClinicalTrials.gov registry entry for NCT06465069 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 420 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Ovarian Cancer appearing as the primary indexed condition, and to 1 intervention — of which LY4052031 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06465069 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Other, New York, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06465069 about?

NCT06465069 is a clinical study titled "A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors". The purpose of this study is to find out whether the study drug, LY4052031, is safe, tolerable and effective in participants with advanced, or metastatic solid tumors including urothelial cancer. The study is conducted in two parts - phase Ia (dose-escalation, dose-optimization) and phase Ib (dose-e...

What is the current status of trial NCT06465069?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 420 participants. The study started on 2024-07-01. Estimated completion is 2027-05.

What conditions does trial NCT06465069 study?

This clinical trial studies the following conditions: Ovarian Cancer, Pancreatic Cancer, Advanced Solid Tumor, Cervical Cancer, Non-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06465069?

The interventions under investigation include: LY4052031 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06465069?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06465069 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Illinois, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial