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ClinicalTrials.gov 73 recruiting now official registry

Myelodysplastic Syndromes clinical trials

73 of 193 indexed Myelodysplastic Syndromes trials are currently recruiting.

193 US clinical trials · 73 currently recruiting

Myelodysplastic Syndromes is the subject of 193 registered US clinical trials on ClinicalTrials.gov, 73 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 148 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 13 of these trials.

The research picture

Myelodysplastic Syndromes has 193 registered US clinical trials, 73 of them open to new participants right now, about 38% of the total.

73
recruiting participants now
38%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
13
top sponsor: Washington University School of Medicine
Phase 180Phase 268Phase 39Phase 42

Active & Recent Trials

193 total, page 1 of 4

RECRUITING 15,000 participants

Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

UNC Lineberger Comprehensive Cancer Center

NCT01137643

RECRUITING 10,000 participants

Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome

Dana-Farber Cancer Institute

NCT02269592

RECRUITING 3,000 participants

Registry of Older Patients With Cancer

UNC Lineberger Comprehensive Cancer Center

NCT01137825

RECRUITING 2,000 participants

The Prospective Collection, Storage and Reporting of Data on Patients Undergoing Hematopoietic Stem Cell Transplantation Utilizing a Standard Preparative Regimen

Wake Forest University Health Sciences

NCT01890486

RECRUITING 1,100 participants

Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult MDS

National Cancer Institute (NCI)

NCT05350748

RECRUITING 1,000 participants

Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples From Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies

National Cancer Institute (NCI)

NCT05588154

RECRUITING NA 700 participants

HEME Home Transfusion Program

Dana-Farber Cancer Institute

NCT06487247

RECRUITING 510 participants

Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

National Cancer Institute (NCI)

NCT07019155

RECRUITING NA 400 participants

Leukemia and Lymphoma Society (LLS) Services Impact on Outcomes and Care

University of Miami

NCT05745285

RECRUITING Phase 3 360 participants

ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions

Bristol-Myers Squibb

NCT05949684

RECRUITING NA 356 participants

Mosaic Trial for Stem Cell Transplant Recipients

Northwestern University

NCT06960993

RECRUITING NA 325 participants

Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in AML and MDS

Washington University School of Medicine

NCT04986657

RECRUITING Phase 2 316 participants

A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

Taiho Oncology

NCT04256317

RECRUITING Phase 1 300 participants

A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

Orca Biosystems

NCT03802695

RECRUITING 300 participants

Protocol For Genomically Profiling, Collecting, Archiving And Distributing Blood And Bone Marrow Specimens From Children And Young Adults With Hematologic Malignancy

Dana-Farber Cancer Institute

NCT04968834

RECRUITING Phase 1 291 participants

Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

Institut de Recherches Internationales Servier

NCT02074839

RECRUITING Phase 1 260 participants

A Study of BGB-11417 in Participants With Myeloid Malignancies

BeiGene

NCT04771130

RECRUITING Phase 1 225 participants

A Study of CTX-712 in Relapsed/Refractory Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndromes

Chordia Therapeutics

NCT05732103

RECRUITING Phase 3 225 participants

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

Takeda

NCT06499285

RECRUITING Phase 1 209 participants

Pre-emptive Therapy With DEC-C to Improve Outcomes in MDS Patients With Measurable Residual Disease Post Allogeneic Hematopoietic Cell Transplant

Washington University School of Medicine

NCT04742634

RECRUITING NA 207 participants

A Telehealth Advance Care Planning Intervention

University of Rochester

NCT05875805

RECRUITING Phase 1 170 participants

A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

BlossomHill Therapeutics

NCT06501196

RECRUITING Phase 2 160 participants

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)

Takeda

NCT04419649

RECRUITING Phase 1 151 participants

Study of SX-682 Alone and in Combination With Oral or Intravenous Decitabine in Subjects With Myelodysplastic Syndrome

Syntrix Biosystems

NCT04245397

RECRUITING Phase 1 150 participants

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

Disc Medicine

NCT05320198

RECRUITING Phase 1 130 participants

A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies

MacroGenics

NCT05362773

RECRUITING Phase 1 100 participants

Study of REM-422 in Patients With AML or Higher Risk MDS

Remix Therapeutics

NCT06297941

RECRUITING Phase 1 99 participants

Venetoclax Plus Intensive Chemotherapy in AML and Advanced MDS

Montefiore Medical Center

NCT05342584

RECRUITING Phase 2 91 participants

Metabolically Optimized, Non-cytotoxic Low Dose Weekly Decitabine/Venetoclax in MDS and AML

Montefiore Medical Center

NCT05184842

RECRUITING Phase 2 80 participants

A Study of Momelotinib in Participants With Low-risk Myelodysplastic Syndrome

GlaxoSmithKline

NCT06847867

RECRUITING Phase 2 80 participants

Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Orca Biosystems

NCT07216443

RECRUITING Phase 2 80 participants

Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors

Children's Hospital of Philadelphia

NCT05194397

RECRUITING Phase 1 75 participants

A Study of TSC-100 and TSC-101 in AML, ALL and MDS in Patients Undergoing Allogeneic Peripheral Blood Stem Transplantation

TScan Therapeutics

NCT05473910

RECRUITING Phase 2 70 participants

Luspatercept for Anemia in Lower Risk MDS or Non-proliferative MDS/MPN Neoplasms

H. Lee Moffitt Cancer Center and Research Institute

NCT05732961

RECRUITING Phase 1 60 participants

Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted Graft

Stanford University

NCT05088356

RECRUITING Phase 2 60 participants

A Phase II Study of Cladribine and Low Dose Cytarabine in Combination With Venetoclax, Alternating With Azacitidine and Venetoclax, in Patients With Higher-risk Myeloproliferative Chronic Myelomonocytic Leukemia or Higher-risk Myelodysplastic Syndromes With Excess Blasts

M.D. Anderson Cancer Center

NCT05365035

RECRUITING NA 60 participants

Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in MDS

Washington University School of Medicine

NCT05434598

RECRUITING Phase 2 56 participants

Allo HSCT Using RIC and PTCy for Hematological Diseases

Masonic Cancer Center, University of Minnesota

NCT05805605

RECRUITING Phase 1 50 participants

UAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy

University of Alabama at Birmingham

NCT06047886

RECRUITING Phase 1 50 participants

A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

Dana-Farber Cancer Institute

NCT04024761

RECRUITING NA 50 participants

CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT

Children's Hospital of Philadelphia

NCT03810196

RECRUITING Phase 1 48 participants

A Study of GLB-001 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher Risk Myelodysplastic Syndromes

GluBio Therapeutics

NCT06146257

RECRUITING Phase 2 48 participants

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

Masonic Cancer Center, University of Minnesota

NCT03579875

RECRUITING Phase 1 47 participants

A Study of LB-100 in Patients With Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS)

Lixte Biotechnology Holdings

NCT03886662

RECRUITING Phase 1 45 participants

HM2023-05: GTB-3650 Trike for High Risk MDS and R/R AML

Masonic Cancer Center, University of Minnesota

NCT06594445

RECRUITING Phase 2 45 participants

Interferon-γ (IFN-γ) With Donor Leukocyte Infusion to Treat Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndromes Post Allogeneic Hematopoietic Stem Cell Transplantation

Sawa Ito, MD

NCT06529731

RECRUITING Phase 2 40 participants

A Pilot, Open-Label Study of Luspatercept for Patients With Lower Risk Myelodysplastic Syndromes (MDS)

M.D. Anderson Cancer Center

NCT06113302

RECRUITING Phase 2 38 participants

Ascorbate in Myelodysplastic Syndrome

Prajwal Dhakal

NCT07283900

RECRUITING Phase 1 38 participants

Danvatirsen Monotherapy Followed by Combination With Venetoclax in Relapsed/Refractory MDS & AML

Montefiore Medical Center

NCT05986240

RECRUITING Phase 2 38 participants

Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen (HLA)-Matched and Partially-HLA Mismatched Allogeneic Transplantation Patients With High-Risk Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), and Myelodysplastic Syndrome (MDS)

University of Illinois at Chicago

NCT06802315

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Phase Distribution

PhaseTrial count
Phase 1 80
Phase 2 68
Phase 3 9
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Myelodysplastic Syndromes Trial Landscape

193 indexed Myelodysplastic Syndromes studies · 73 recruiting (38%).

Phase mix: 11 late (III/IV) vs 148 early (I/II).

Top sponsor: Washington University School of Medicine (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Myelodysplastic Syndromes?

PlainTrial tracks 193 US clinical trials for Myelodysplastic Syndromes, of which 73 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Myelodysplastic Syndromes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.