Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

NCT06545942 · View on ClinicalTrials.gov ↗

Study Summary

This Phase 1, multi-center, open-label, dose escalation and dose optimization study is designed to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and preliminary clinical activity of MOMA-313 administered orally as a single agent or combination therapy in patients with homologous recombinant deficient solid tumors.

Interventions

  • DRUG Olaparib
  • DRUG MOMA-313

Study Locations (18)

Other

  • Investigative Site #114 — Barcelona
  • Investigative Site #116 — Barcelona
  • Investigative Site #115 — Madrid
  • Investigative Site #113 — London
  • Investigative Site #117 — Manchester
  • Investigative Site #118 — Newcastle upon Tyne

California

  • Investigative Site #101 — La Jolla
  • Investigative Site #111 — San Francisco

New York

  • Investigative Site #103 — New York
  • Investigative Site #106 — New York

Arizona

  • Investigative Site #108 — Goodyear

Florida

  • Investigative Site #104 — Lake Mary

Missouri

  • Investigative Site #110 — St Louis

Pennsylvania

  • Investigative Site #109 — Philadelphia

South Carolina

  • Investigative Site #107 — Myrtle Beach

Trial Details

FieldValue
Enrollment Target 220 participants
Start Date 2024-08-13
Est. Completion 2027-11-30
Phase Phase 1

Sponsor

MOMA Therapeutics

33 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06545942

The ClinicalTrials.gov registry entry for NCT06545942 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 220 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is MOMA Therapeutics, which has 33 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 7 conditions, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions — of which Olaparib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06545942 reports 18 study locations spanning 11 distinct geographic areas — top geographies include Other, California, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06545942 about?

NCT06545942 is a clinical study titled "Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors". This Phase 1, multi-center, open-label, dose escalation and dose optimization study is designed to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and preliminary clinical activity of MOMA-313 administered orally as a single agent or combination therapy in patients wi...

What is the current status of trial NCT06545942?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 220 participants. The study started on 2024-08-13. Estimated completion is 2027-11-30.

What conditions does trial NCT06545942 study?

This clinical trial studies the following conditions: Breast Cancer, Prostate Cancer, Ovarian Cancer, Advanced Solid Tumor, Pancreas Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06545942?

The interventions under investigation include: Olaparib (DRUG), MOMA-313 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06545942?

This trial is sponsored by MOMA Therapeutics, which has 33 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06545942 being conducted?

This trial has 18 study locations across Arizona, California, Florida, Missouri, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial