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A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors
NCT06238479 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to find out whether the study drug, LY4101174, is safe, tolerable and effective in participants with select advanced or metastatic solid tumors. The study is conducted in two parts - phase Ia (dose-escalation, dose-optimization) and phase Ib (dose-expansion). The study will last up to approximately 4 years.
Conditions Studied
Interventions
- DRUG LY4101174
Study Locations (20)
Other
- Austin Health — Heidelberg
- Icon Cancer Centre Kurralta Park — Kurralta Park
- Institut Jules Bordet — Anderlecht
- Peking University First Hospital — Beijing
- Hunan Cancer Hospital — Changsha
- Shanghai East Hospital — Shanghai
- Centre Oscar Lambret — Lille
- Centre Leon Berard — Lyon
- Institut Paoli-Calmettes — Marseille
- CHU Strasbourg-Hautepierre — Strasbourg
- Gustave Roussy — Villejuif
New York
- Perlmutter Cancer Center at NYU Langone Hospital - Long Island — Mineola
- Laura & Isaac Perlmutter Cancer Center at NYU Langone Health — New York
- Memorial Sloan Kettering Cancer Center — New York
Texas
- UT Southwestern Medical Center — Dallas
- South Texas Accelerated Research Therapeutics (START) — San Antonio
Florida
- AdventHealth Orlando — Orlando
Georgia
- Emory University — Atlanta
Massachusetts
- Massachusetts General Hospital — Boston
Missouri
- Washington University School of Medicine — St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 490 participants |
| Start Date | 2024-03-05 |
| Est. Completion | 2027-03 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06238479
The ClinicalTrials.gov registry entry for NCT06238479 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 490 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Ovarian Cancer appearing as the primary indexed condition, and to 1 intervention — of which LY4101174 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06238479 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Other, New York, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06238479 about?
NCT06238479 is a clinical study titled "A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors". The purpose of this study is to find out whether the study drug, LY4101174, is safe, tolerable and effective in participants with select advanced or metastatic solid tumors. The study is conducted in two parts - phase Ia (dose-escalation, dose-optimization) and phase Ib (dose-expansion). The study w...
What is the current status of trial NCT06238479?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 490 participants. The study started on 2024-03-05. Estimated completion is 2027-03.
What conditions does trial NCT06238479 study?
This clinical trial studies the following conditions: Ovarian Cancer, Pancreatic Cancer, Advanced Solid Tumor, Cervical Cancer, Non-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06238479?
The interventions under investigation include: LY4101174 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06238479?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06238479 being conducted?
This trial has 20 study locations across Florida, Georgia, Massachusetts, Missouri, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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