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NCT00004577 · ClinicalTrials.gov registry record

Study of New Magnetic Resonance Imaging Methods of the Brain

A clinical trial of Healthy and Healthy Volunteer, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).

Recruiting
Registry status
1,100
Enrollment target
1
Study location

NCT00004577: Recruiting study of Healthy and Healthy Volunteer, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).

NCT00004577 is a study of Healthy and Healthy Volunteer that is actively recruiting participants, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 1,100 participants, above the 646-participant average among 1,090 other Healthy trials with a reported enrollment target (70% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00004577, a study of Healthy and Healthy Volunteer, is actively recruiting participants, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).

RECRUITING
Registry status
1,100 participants
Enrollment target
1
Study location

Study Summary

The purpose of this investigation is to develop improved magnetic resonance imaging (MRI) techniques and hardware for studying brain function. MRI is a diagnostic tool that provides information about brain chemistry and physiology. This study will evaluate new MRI methods for monitoring blood flow to regions of the brain in response to simple tasks. The MRI machine used in this study is more powerful than those in most hospitals, permitting a higher visual resolution. Normal healthy volunteers over 18 years old may be eligible for this study. Candidates will be screened with a medical history and questionnaire, and a neurological examination. Study participants will have a yearly MRI scan. For this procedure, the subject lies on a stretcher that is moved into a donut-shaped machine with a strong magnetic field. A lightweight circular or rectangular coil a device that improves the quality of the images may be placed on the head. The scan time varies from 20 minutes to 3 hours; most scans last between 45 and 90 minutes. During the scan, the subject may perform simple tasks, such as listening to tapes, tapping a finger, moving a hand, watching a screen, or smelling a fragrance. More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons. Information from this study will be used to develop better imaging methods that will, in turn, permit a greater understanding of normal and abnormal brain behaviors.

Primary Outcome

The primary outcome of this study will be the ability to robustly acquire whole brain MRI sensitized to myelin, iron, diffusion, perfusion, and fiber orientation. Perfusion- and BOLD- based fMRI techniques will allow distinguishing between neuronal and systemic vascular signal contributions. In addition, we anticipate the ability to acquire (proton) spectroscopic data at 5mm resolution.

Conditions Studied

Healthy Healthy Volunteer Magnetic Resonance Imaging Adult fMRI Brain Mapping

Study Locations (1)

Maryland

  • National Institutes of Health Clinical Center - Bethesda

Trial Details

FieldValue
Enrollment Target 1,100 participants
Start Date 2000-07-01
National Institute of Neurological Disorders and Stroke (NINDS)

567 total trials

What NCT00004577 shows while recruiting

NCT00004577 is an observational study that tracks outcomes without assigning an intervention. Its 1,100 participants enrollment target places it among the larger protocols in the corpus, above the 646-participant average among 1,090 other Healthy trials with a reported enrollment target (70% higher).

The record links to 6 conditions, with Healthy appearing as the primary indexed condition, and to 0 interventions.

NCT00004577 reports a single indexed study location in Maryland.

Frequently Asked Questions

What is clinical trial NCT00004577 about?

NCT00004577 is a clinical study titled "Study of New Magnetic Resonance Imaging Methods of the Brain". The purpose of this investigation is to develop improved magnetic resonance imaging (MRI) techniques and hardware for studying brain function. MRI is a diagnostic tool that provides information about brain chemistry and physiology. This study will evaluate new MRI methods for monitoring blood flow t...

What is the current status of trial NCT00004577?

This trial is currently recruiting. The enrollment target is 1,100 participants. The study started on 2000-07-01.

What conditions does trial NCT00004577 study?

This clinical trial studies the following conditions: Healthy, Healthy Volunteer, Magnetic Resonance Imaging, Adult, fMRI.

Who is sponsoring clinical trial NCT00004577?

This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00004577 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Healthy

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00004577's enrollment target sits among peer trials

1,100 28th of 1090 higher than 1,063 of 1,090 other Healthy trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT00004577

Source: ClinicalTrials.gov NCT00004577, the US trial registry maintained by the National Library of Medicine. NCT00004577 (large enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.