National Institute of Neurological Disorders and Stroke (NINDS)
National Institute of Neurological Disorders and Stroke (NINDS) sponsors 567 registered US clinical trials on ClinicalTrials.gov, 48 of them currently recruiting, and 467 completed. 16 of these trials are in Phase 3-4 (later-stage) and 158 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 23 trials.
Trial Pipeline
567 total, page 2 of 12
Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis
NCT04742400
Clinical Laboratory Evaluation of Chronic Autonomic Failure
NCT03648905
Deep Brain Stimulation Surgery for Focal Hand Dystonia
NCT02911103
Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy
NCT02362438
A Prospective Natural History Study of Patients With Syringomyelia
NCT01150708
Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease
NCT00005902
Longitudinal Natural History Protocol for PRKN- and PINK1-Linked PD
NCT07613112
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
NCT07388550
Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain
NCT02522611
Procedural Motor Memory in Long COVID-19
NCT05746624
Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory
NCT04694131
NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal Leukoencephalopathy
NCT04781309
Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex
NCT04431011
Acute Effects of Medium Chain Triglyceride (MCT) Nutritional Ketosis on Parkinson's Disease (PD) Symptoms and Biomarkers (MCT-PD)
NCT04584346
Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis
NCT04344470
Clinical Correlates of COVID-19 Pandemic in Patients With Functional Movement Disorder (FMD) and Parkinson's Disease (PD)
NCT04565080
An Observational Study of Neurologic Function After COVID-19 Infection
NCT04564287
Assessing Clinical Endpoints and Biomarkers in Myotonic Dystrophy Type-1 and Type 2 (ASCEND-DM)
NCT03867435
Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis
NCT04025554
Modulating the Hippocampal and Striatal Memory Networks With rTMS
NCT03994120
HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)
NCT02437110
Exploring the Relationship Between Brain Asymmetry and Attention
NCT03789201
Large-Scale Online Studies of Early Motor Skill Learning
NCT03733080
Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade
NCT03493932
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
NCT03366129
PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection
NCT03239899
Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in People With Functional Movement Disorders
NCT03263013
Pathophysiology of Focal Hand Dystonia
NCT03223623
Photic Blink Reflex in People With Blepharospasm and Increased Blinking
NCT03263000
Chart Review: Central Motor Conduction Time in Neurological Disorders
NCT03300856
Measuring the Latency Connectome in the Central Nervous Systems Using Neuroimaging and Neurophysiological Techniques
NCT03223636
Does N-Acetylcysteine Decrease Spontaneous Oxidation of Central Neural Dopamine in Parkinson's Disease?
NCT03104725
Loss of Depotentiation in Focal Dystonia
NCT03206112
Clinical and Physiological Studies of Tremor Syndromes
NCT03027310
Neurophysiologic Study of Patient With Essential Tremor and Dystonic Tremor
NCT03041714
Functional Connectivity as a Biomarker of rTMS
NCT03050801
Neurophysiology of Surround Inhibition in the Human Motor Cortex
NCT03018262
Cholinergic Receptor Imaging in Dystonia
NCT02689466
Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31
NCT02859428
Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation
NCT02911129
Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health
NCT02669212
Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells
NCT02694783
In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging
NCT02511028
Propensity to Develop Plasticity in the Parieto-Motor Networks in Dystonia From the Perspective of Abnormal High-Order Motor Processing
NCT02504905
Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection
NCT02527460
Natural History of Multiple Sclerosis and Its Mimickers
NCT02504840
Oral Guanabenz for Multiple Sclerosis
NCT02423083
Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function
NCT02408900
Neural Basis of Decision-Making Deficits in Traumatic Brain Injury
NCT02169310
Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy
NCT02124057
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 80 |
| Phase 2 | 78 |
| Phase 3 | 11 |
| Phase 4 | 5 |
Therapeutic Areas
What the Pipeline for National Institute of Neurological Disorders and Stroke (NINDS) Shows
According to the ClinicalTrials.gov registry, National Institute of Neurological Disorders and Stroke (NINDS) is linked to 567 US clinical trials across every stage of research activity. Of those, 48 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 467 are already marked complete, representing roughly 82% of the total.
The phase mix for National Institute of Neurological Disorders and Stroke (NINDS) reports 16 late-stage studies (Phase 3 and Phase 4 combined) and 158 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Institute of Neurological Disorders and Stroke (NINDS) is Healthy with 23 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.