National Institute of Neurological Disorders and Stroke (NINDS)

567 total trials 48 currently recruiting 467 completed

National Institute of Neurological Disorders and Stroke (NINDS) sponsors 567 registered US clinical trials on ClinicalTrials.gov, 48 of them currently recruiting, and 467 completed. 16 of these trials are in Phase 3-4 (later-stage) and 158 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 23 trials.

Trial Pipeline

567 total, page 2 of 12

ACTIVE NOT RECRUITING Phase 2

Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

NCT04742400

ACTIVE NOT RECRUITING

Clinical Laboratory Evaluation of Chronic Autonomic Failure

NCT03648905

ACTIVE NOT RECRUITING Phase 1

Deep Brain Stimulation Surgery for Focal Hand Dystonia

NCT02911103

ACTIVE NOT RECRUITING Phase 1

Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

NCT02362438

ACTIVE NOT RECRUITING

A Prospective Natural History Study of Patients With Syringomyelia

NCT01150708

ACTIVE NOT RECRUITING

Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease

NCT00005902

NOT YET RECRUITING

Longitudinal Natural History Protocol for PRKN- and PINK1-Linked PD

NCT07613112

NOT YET RECRUITING Phase 1

Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)

NCT07388550

NOT YET RECRUITING Phase 1

Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain

NCT02522611

COMPLETED

Procedural Motor Memory in Long COVID-19

NCT05746624

COMPLETED NA

Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory

NCT04694131

COMPLETED Early Phase 1

NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal Leukoencephalopathy

NCT04781309

COMPLETED

Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

NCT04431011

COMPLETED Phase 1

Acute Effects of Medium Chain Triglyceride (MCT) Nutritional Ketosis on Parkinson's Disease (PD) Symptoms and Biomarkers (MCT-PD)

NCT04584346

COMPLETED NA

Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis

NCT04344470

COMPLETED

Clinical Correlates of COVID-19 Pandemic in Patients With Functional Movement Disorder (FMD) and Parkinson's Disease (PD)

NCT04565080

COMPLETED

An Observational Study of Neurologic Function After COVID-19 Infection

NCT04564287

TERMINATED

Assessing Clinical Endpoints and Biomarkers in Myotonic Dystrophy Type-1 and Type 2 (ASCEND-DM)

NCT03867435

COMPLETED Phase 1

Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

NCT04025554

COMPLETED NA

Modulating the Hippocampal and Striatal Memory Networks With rTMS

NCT03994120

COMPLETED Phase 1

HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

NCT02437110

COMPLETED NA

Exploring the Relationship Between Brain Asymmetry and Attention

NCT03789201

COMPLETED

Large-Scale Online Studies of Early Motor Skill Learning

NCT03733080

COMPLETED Phase 1

Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade

NCT03493932

COMPLETED

Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke

NCT03366129

COMPLETED Phase 1

PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection

NCT03239899

COMPLETED

Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in People With Functional Movement Disorders

NCT03263013

COMPLETED NA

Pathophysiology of Focal Hand Dystonia

NCT03223623

TERMINATED

Photic Blink Reflex in People With Blepharospasm and Increased Blinking

NCT03263000

COMPLETED

Chart Review: Central Motor Conduction Time in Neurological Disorders

NCT03300856

COMPLETED

Measuring the Latency Connectome in the Central Nervous Systems Using Neuroimaging and Neurophysiological Techniques

NCT03223636

TERMINATED Phase 1

Does N-Acetylcysteine Decrease Spontaneous Oxidation of Central Neural Dopamine in Parkinson's Disease?

NCT03104725

TERMINATED

Loss of Depotentiation in Focal Dystonia

NCT03206112

COMPLETED

Clinical and Physiological Studies of Tremor Syndromes

NCT03027310

COMPLETED

Neurophysiologic Study of Patient With Essential Tremor and Dystonic Tremor

NCT03041714

COMPLETED Phase 1

Functional Connectivity as a Biomarker of rTMS

NCT03050801

COMPLETED

Neurophysiology of Surround Inhibition in the Human Motor Cortex

NCT03018262

COMPLETED

Cholinergic Receptor Imaging in Dystonia

NCT02689466

TERMINATED

Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31

NCT02859428

COMPLETED

Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation

NCT02911129

COMPLETED NA

Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health

NCT02669212

COMPLETED Early Phase 1

Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells

NCT02694783

COMPLETED Phase 1

In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging

NCT02511028

COMPLETED Early Phase 1

Propensity to Develop Plasticity in the Parieto-Motor Networks in Dystonia From the Perspective of Abnormal High-Order Motor Processing

NCT02504905

TERMINATED Phase 1

Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

NCT02527460

COMPLETED

Natural History of Multiple Sclerosis and Its Mimickers

NCT02504840

TERMINATED Phase 1

Oral Guanabenz for Multiple Sclerosis

NCT02423083

COMPLETED

Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function

NCT02408900

COMPLETED Phase 1

Neural Basis of Decision-Making Deficits in Traumatic Brain Injury

NCT02169310

COMPLETED

Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy

NCT02124057

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Phase Distribution

PhaseTrial count
Phase 1 80
Phase 2 78
Phase 3 11
Phase 4 5

What the Pipeline for National Institute of Neurological Disorders and Stroke (NINDS) Shows

According to the ClinicalTrials.gov registry, National Institute of Neurological Disorders and Stroke (NINDS) is linked to 567 US clinical trials across every stage of research activity. Of those, 48 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 467 are already marked complete, representing roughly 82% of the total.

The phase mix for National Institute of Neurological Disorders and Stroke (NINDS) reports 16 late-stage studies (Phase 3 and Phase 4 combined) and 158 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute of Neurological Disorders and Stroke (NINDS) is Healthy with 23 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.