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Parkinson's Disease clinical trials
40 of 159 indexed Parkinson's Disease trials are currently recruiting.
159 US clinical trials · 40 currently recruiting
Parkinson's Disease is the subject of 159 registered US clinical trials on ClinicalTrials.gov, 40 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 55 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
The research picture
Parkinson's Disease has 159 registered US clinical trials, 40 of them open to new participants right now, about 25% of the total.
- 40
- recruiting participants now
- 25%
- of trials open to enrollment
- 21
- in Phase 3–4 (later-stage)
- 16
- top sponsor: VA Office of Research and Development
Active & Recent Trials
159 total, page 1 of 4
Parkinson's Foundation PD GENEration Genetic Registry
Parkinson's Foundation
NCT04994015
Physiological Brain Atlas Development
Vanderbilt University Medical Center
NCT00575081
The Parkinson's Genetic Research Study
University of Washington
NCT01558479
Natural History Protocol for Movement Disorders
National Institute of Neurological Disorders and Stroke (NINDS)
NCT05413291
Retinal Imaging in Neurodegenerative Disease
Duke University
NCT03233646
Modifiable Variables in Parkinsonism (MVP)
Bastyr University
NCT02194816
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
Boston Scientific Corporation
NCT02071134
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
Hoffmann-La Roche
NCT07174310
Parkinson's Disease in Asian Americans
Tufts University
NCT05532982
Deep Brain Stimulation Therapy in Movement Disorders
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02119611
Deep Brain Stimulation Surgery for Movement Disorders
National Institute of Neurological Disorders and Stroke (NINDS)
NCT01581580
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
National Institute of Mental Health (NIMH)
NCT04396873
Sensory-specific Peripheral Stimulation for Tremor Management
Shirley Ryan AbilityLab
NCT04501133
Telemedicine Intervention in Patients With Chronic Pain in PD
VA Office of Research and Development
NCT05410392
Gait Analysis in Neurological Disease
Beth Israel Deaconess Medical Center
NCT02994719
Imaging Depression in Parkinson's Disease
Yale University
NCT06402955
A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease
Prevail Therapeutics
NCT06565195
Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease
VA Office of Research and Development
NCT06405334
Udall Project 1 Aim 4
University of Minnesota
NCT05568199
Ketamine for Veterans With Parkinson's Disease
VA Office of Research and Development
NCT06231563
Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease
Douglas Scharre
NCT03019757
Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson's Disease
VA Office of Research and Development
NCT05298150
Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's Disease
Michael J. Fox Foundation for Parkinson's Research
NCT07020026
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications
InSightec
NCT05539196
rTMS to Improve Cognition in Parkinson's
VA Office of Research and Development
NCT03836950
Speech Learning and Speech Production in Parkinson's Disease
State University of New York at Buffalo
NCT07403539
Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease
VA Office of Research and Development
NCT05400499
PET Imaging Evaluation of [11C]SY08
Massachusetts General Hospital
NCT06098612
Efficacy of a Breathwork Practice (SKY) on Well-Being of Individuals With Parkinson's Disease (iPD) and Care Partners
Nova Southeastern University
NCT06581523
Feasibility and Safety of a Portable Exoskeleton to Improve Mobility in Parkinson's Disease
VA Office of Research and Development
NCT06028529
Tenapanor in Synucleinopathy-Related Constipation
Cedar Valley Digestive Health Center
NCT06460038
Patterned Multichannel Vibrotactile Stimulation for the Longitudinal Treatment of Moderate Stage Parkinson's Disease
Synergic Medical Technologies
NCT05830110
A Multicenter Study to Evaluate Safety, Tolerability, and Clinical Responses of DSP-1083 Into Subjects With Parkinson's Disease
Sumitomo Pharma America
NCT06753331
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
University of Minnesota
NCT05557864
A Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Brain for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Undergoing DBS Surgery
Craig van Horne, MD, PhD
NCT06683378
Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease
Invicro
NCT07348250
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)
University of Nebraska
NCT05070013
Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease
University of Nebraska
NCT04799470
Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
Helen M. Bronte-Stewart
NCT05968703
Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies
Craig van Horne, MD, PhD
NCT06683365
Rostock International Parkinson's Disease Study (ROPAD)
CENTOGENE GmbH Rostock
NCT03866603
A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease
Hoffmann-La Roche
NCT04777331
Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders:
InSightec
NCT03100474
Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations
NeuroDerm
NCT04006210
PET Imaging in Parkinson Disease Dementia
Washington University School of Medicine
NCT01052350
A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease
Hoffmann-La Roche
NCT03100149
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
Bial R&D Investments, S.A.
NCT05819359
A Long Term Safety Study of ND0612 Administered as a Continuous SC Infusion in Advanced Parkinson's Disease
NeuroDerm
NCT02726386
Noninterventional Study Evaluating Parkinson's Disease Diary Use
BlueRock Therapeutics
NCT05363046
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
AskBio
NCT05699460
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 31 |
| Phase 3 | 11 |
| Phase 4 | 10 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Parkinson's Disease Trial Landscape
159 indexed Parkinson's Disease studies · 40 recruiting (25%).
Phase mix: 21 late (III/IV) vs 55 early (I/II).
Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Parkinson's Disease?
PlainTrial tracks 159 US clinical trials for Parkinson's Disease, of which 40 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Parkinson's Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.