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Parkinson's Disease: early-phase trial registry
42 of 161 indexed Parkinson's Disease trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #67 of 28,707 conditions by registered trial count.
161 US clinical trials · 42 currently recruiting · #67 of 28,707 conditions by registered trial count
Parkinson's Disease: 161 US clinical trials tracked, 42 recruiting.
Parkinson's Disease is the subject of 161 registered US clinical trials on ClinicalTrials.gov, 42 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 55 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
Enrollment posture brief
Registry condition parkinsons-disease
OPEN 42 | RECR 26% | LATE 21 | EARLY 55 | RANK #67 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Barrett's Esophagus (26% recruiting · 23 trials)
Parkinson's Disease lists 42 open slots (26% of 161 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Parkinson's Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Parkinson's Disease is recruiting below its size-band peers.
42 of 161 indexed trials (26.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Parkinson's Disease trials is spread across many organizations.
VA Office of Research and Development accounts for 16 of 161 trials (9.9%). 99 distinct sponsors appear on at least one study for this condition label.
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Most Parkinson's Disease trials plan to enrol fewer than 100 people.
Median target enrolment is 51 among the 159 trials that report a genuine target (sentinel values excluded). 100 of those (62.9%) plan for fewer than 100 participants.
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Parkinson's Disease research is mostly interventional.
114 interventional and 47 observational studies make up this index (70.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
161 total, page 1 of 4
Parkinson's Foundation PD GENEration Genetic Registry
Parkinson's Foundation
NCT04994015
Physiological Brain Atlas Development
Vanderbilt University Medical Center
NCT00575081
The Parkinson's Genetic Research Study
University of Washington
NCT01558479
Natural History Protocol for Movement Disorders
National Institute of Neurological Disorders and Stroke (NINDS)
NCT05413291
Retinal Imaging in Neurodegenerative Disease
Duke University
NCT03233646
Modifiable Variables in Parkinsonism (MVP)
Bastyr University
NCT02194816
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
Boston Scientific Corporation
NCT02071134
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
Hoffmann-La Roche
NCT07174310
Parkinson's Disease in Asian Americans
Tufts University
NCT05532982
Deep Brain Stimulation Therapy in Movement Disorders
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02119611
Deep Brain Stimulation Surgery for Movement Disorders
National Institute of Neurological Disorders and Stroke (NINDS)
NCT01581580
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
National Institute of Mental Health (NIMH)
NCT04396873
Sensory-specific Peripheral Stimulation for Tremor Management
Shirley Ryan AbilityLab
NCT04501133
Telemedicine Intervention in Patients With Chronic Pain in PD
VA Office of Research and Development
NCT05410392
Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease
Oregon Health and Science University
NCT06772220
Gait Analysis in Neurological Disease
Beth Israel Deaconess Medical Center
NCT02994719
Imaging Depression in Parkinson's Disease
Yale University
NCT06402955
A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease
Prevail Therapeutics
NCT06565195
Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease
VA Office of Research and Development
NCT06405334
Udall Project 1 Aim 4
University of Minnesota
NCT05568199
Ketamine for Veterans With Parkinson's Disease
VA Office of Research and Development
NCT06231563
Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease
Douglas Scharre
NCT03019757
Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson's Disease
VA Office of Research and Development
NCT05298150
Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's Disease
Michael J. Fox Foundation for Parkinson's Research
NCT07020026
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications
InSightec
NCT05539196
rTMS to Improve Cognition in Parkinson's
VA Office of Research and Development
NCT03836950
Speech Learning and Speech Production in Parkinson's Disease
State University of New York at Buffalo
NCT07403539
Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease
VA Office of Research and Development
NCT05400499
PET Imaging Evaluation of [11C]SY08
Massachusetts General Hospital
NCT06098612
Efficacy of a Breathwork Practice (SKY) on Well-Being of Individuals With Parkinson's Disease (iPD) and Care Partners
Nova Southeastern University
NCT06581523
Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder
CND Life Sciences
NCT07217054
Feasibility and Safety of a Portable Exoskeleton to Improve Mobility in Parkinson's Disease
VA Office of Research and Development
NCT06028529
Tenapanor in Synucleinopathy-Related Constipation
Cedar Valley Digestive Health Center
NCT06460038
Patterned Multichannel Vibrotactile Stimulation for the Longitudinal Treatment of Moderate Stage Parkinson's Disease
Synergic Medical Technologies
NCT05830110
A Multicenter Study to Evaluate Safety, Tolerability, and Clinical Responses of DSP-1083 Into Subjects With Parkinson's Disease
Sumitomo Pharma America
NCT06753331
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
University of Minnesota
NCT05557864
A Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Brain for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Undergoing DBS Surgery
Craig van Horne, MD, PhD
NCT06683378
Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease
Invicro
NCT07348250
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)
University of Nebraska
NCT05070013
Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease
University of Nebraska
NCT04799470
Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
Helen M. Bronte-Stewart
NCT05968703
Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies
Craig van Horne, MD, PhD
NCT06683365
Rostock International Parkinson's Disease Study (ROPAD)
CENTOGENE GmbH Rostock
NCT03866603
A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease
Hoffmann-La Roche
NCT04777331
Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders:
InSightec
NCT03100474
Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations
NeuroDerm
NCT04006210
PET Imaging in Parkinson Disease Dementia
Washington University School of Medicine
NCT01052350
A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease
Hoffmann-La Roche
NCT03100149
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
Bial R&D Investments, S.A.
NCT05819359
A Long Term Safety Study of ND0612 Administered as a Continuous SC Infusion in Advanced Parkinson's Disease
NeuroDerm
NCT02726386
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 31 |
| Phase 3 | 11 |
| Phase 4 | 10 |
Top Sponsors
Named interventions
Most-linked intervention names on Parkinson's Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Parkinson's Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Parkinson's Disease page
161 registered trials, 42 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 42 Parkinson's Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Parkinson's Disease trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Parkinson's Disease condition card totals 161 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.