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NCT06472622 · ClinicalTrials.gov registry record · Early Phase 1
Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
A Early Phase 1 study of Fatigue Syndrome, Chronic, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 47
- Enrollment target
- 1
- Study location
NCT06472622: Recruiting Early Phase 1 study of Fatigue Syndrome, Chronic, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT06472622 is a Early Phase 1 study of Fatigue Syndrome, Chronic that is actively recruiting participants, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 47 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (11% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06472622, a Early Phase 1 study of Fatigue Syndrome, Chronic, is actively recruiting participants, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 47 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: The way the brain processes rewards and punishments may play a role in some disorders of the nervous system. People with chronic overlapping pain conditions (such as myalgic encephalomyelitis/chronic fatigue syndrome \[ME/CFS\]) may have heightened responses to unpleasant, punishing sensations. Some of these conditions may also cause heightened responses to effort; this is an unpleasant sensation felt during physical and mental exertion. Objective: To learn more about how the brain processes different unpleasant sensations. Eligibility: People aged 18 to 50 years with ME/CFS. Healthy volunteers are also needed. Design: Participants will have 3 visits in 1 to 5 weeks. Visit 1: Participants may have a neurologic exam. They will have a mock magnetic resonance imaging (MRI) scan. They will lie on a bed in a wooden tube while they practice 2 tasks: Thermal pain rating: A device that creates mild to moderate heat will be placed on one leg. Physical effort rating: Participants will squeeze a plastic bar with different levels of force. Visit 2: Participants will have a real MRI scan. They will lie on a table that slides into a large tube. Visit 3: Participants will have another MRI scan. They will repeat the thermal pain and physical effort tasks while in the scanner. Sensors will be placed on 1 arm to measure how the muscles function as they squeeze the bar. Their heart rate will be tested: They will hold their finger against a camera lens for 1 minute. They will do 2 other tasks: 1 requires repeatedly pressing a key on a keyboard, and the other requires squeezing a bar.
Primary Outcome
SVN regions in which activity is significantly associated with unpleasantness of pain.
Conditions Studied
Interventions
- DEVICE Thermal Pain Stimulation
- DEVICE Physical Effort Stimulation
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 47 participants |
| Start Date | 2025-04-09 |
| Est. Completion | 2034-06-30 |
| Phase | Early Phase 1 |
What NCT06472622 shows while recruiting
NCT06472622 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 47 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (11% lower).
The record links to 1 condition, with Fatigue Syndrome, Chronic appearing as the primary indexed condition, and to 2 interventions - of which Thermal Pain Stimulation is the first listed.
NCT06472622 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT06472622 about?
NCT06472622 is a clinical study titled "Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort". Background: The way the brain processes rewards and punishments may play a role in some disorders of the nervous system. People with chronic overlapping pain conditions (such as myalgic encephalomyelitis/chronic fatigue syndrome \[ME/CFS\]) may have heightened responses to unpleasant, punishing sen...
What is the current status of trial NCT06472622?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 47 participants. The study started on 2025-04-09. Estimated completion is 2034-06-30.
What conditions does trial NCT06472622 study?
This clinical trial studies the following conditions: Fatigue Syndrome, Chronic.
What interventions are being tested in trial NCT06472622?
The interventions under investigation include: Thermal Pain Stimulation (DEVICE), Physical Effort Stimulation (DEVICE).
Who is sponsoring clinical trial NCT06472622?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06472622 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06472622's enrollment target sits among peer trials
47 563rd of 2000 higher than 1,436 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
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Source ClinicalTrials.gov registry export · 2026-08-08
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