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Epilepsy: early-phase trial registry
78 of 164 indexed Epilepsy trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #65 of 28,707 conditions by registered trial count.
164 US clinical trials · 78 currently recruiting · #65 of 28,707 conditions by registered trial count
Epilepsy: 164 US clinical trials tracked, 78 recruiting.
Epilepsy is the subject of 164 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 39 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 9 of these trials.
Enrollment posture brief
Registry condition epilepsy
OPEN 78 | RECR 48% | LATE 21 | EARLY 39 | RANK #65 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Microbial Colonization (48% recruiting · 21 trials)
Epilepsy lists 78 open slots (48% of 164 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Epilepsy on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Epilepsy is recruiting above its size-band peers.
78 of 164 indexed trials (47.6%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Epilepsy trials is spread across many organizations.
National Institute of Neurological Disorders and Stroke (NINDS) accounts for 9 of 164 trials (5.5%). 95 distinct sponsors appear on at least one study for this condition label.
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Most Epilepsy trials plan to enrol fewer than 100 people.
Median target enrolment is 60 among the 161 trials that report a genuine target (sentinel values excluded). 103 of those (64%) plan for fewer than 100 participants.
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Epilepsy research is mostly interventional.
120 interventional and 44 observational studies make up this index (73.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
164 total, page 1 of 4
Epilepsy Learning Healthcare System (ELHS)
Epilepsy Foundation of America
NCT06265103
De-identified UNMH EEG Corpus Database Creation With Fully De-identified Clinical Information
University of New Mexi
NCT05140265
Genetics of Epilepsy and Related Disorders
Boston Children's Hospital
NCT01858285
Physiological Brain Atlas Development
Vanderbilt University Medical Center
NCT00575081
Human Epilepsy Genetics--Neuronal Migration Disorders Study
Harvard University Faculty of Medicine
NCT00041600
Investigating Epilepsy: Screening and Evaluation
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03478852
Patterns of Neurodevelopmental Disorders
Richard Frye
NCT06213090
Registry and Natural History of Epilepsy-Dyskinesia Syndromes
Boston Children's Hospital
NCT06967727
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02107989
Genetic Markers of Cardiovascular Disease in Epilepsy
Mayo Clinic
NCT02824822
A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes
Boston Children's Hospital
NCT06585605
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
Southwest Autism Research & Resource Center
NCT04322734
Carbon Dioxide (CO2) Chemosensitivity and SUDEP
University of Iowa
NCT04134754
Surgery as a Treatment for Medically Intractable Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT01273129
Localizing Epileptic Networks Using MRI and iEEG
University of Pennsylvania
NCT04649008
Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits
VA Office of Research and Development
NCT04419272
Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
Epiminder America
NCT07110454
Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive Variables in Epilepsy Patients
Baylor College of Medicine
NCT05283811
AI-Based Mobile Intervention on Medication Non-Adherence and Transition
University of Central Florida
NCT07445074
Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
Neuroelectrics Corporation
NCT04770337
Human Intracranial Electrophysiology
Dartmouth-Hitchcock Medical Center
NCT05529264
Cognitive Enhancement Intervention for Creating a Healthy L.I.F.E (Lifestyle Interventions for Epilepsy)
Kayela Arrotta
NCT05954182
MEHMO Natural History and Biomarkers
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT06019182
Research Evaluating Vagal Excitation AND Anatomical Links
University of Minnesota
NCT06143293
Telephone-Based Support Programs for People With Epilepsy
NYU Langone Health
NCT05082181
Tumor Related Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02639325
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)
University of Missouri-Columbia
NCT07329257
Sleep Spindles and Memory in Rolandic Epilepsy
Massachusetts General Hospital
NCT04569708
Amygdala Memory Enhancement
Washington University School of Medicine
NCT05065450
Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG)
CREmedical
NCT05944692
ESIS in Pediatric DRE
Sarah Katie Ihnen
NCT05469373
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
Baylor College of Medicine
NCT05418894
Functional Brain Mapping for Patients with Epilepsy
Wayne State University
NCT05755919
Mapping of Human Cognition
The University of Texas Health Science Center, Houston
NCT05989893
Subcortical Arousal in Perceptual Awareness
Yale University
NCT06934356
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
Suninflam
NCT07051629
A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures
UCB Biopharma SRL
NCT04715646
Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System.
Epitel
NCT06027749
Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
Darcy Krueger
NCT05104983
Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery
Kayela Arrotta
NCT05992402
Physiological-based Pharmacokinetics Approach to Medication Exposure During Pregnancy and Breastfeeding
University of Pittsburgh
NCT05450978
Implementation and Cost Evaluation of Project UPLIFT
Emory University
NCT06865820
A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy
Praxis Precision Medicines
NCT05737784
Collaborative Care for Anxiety and Depression in Epilepsy
Wake Forest University Health Sciences
NCT05559749
Microelectrode Recordings From the Vagus Nerve in Awake Humans
University of Minnesota
NCT06016686
Pharmacological Modulation of Brain Oscillations in Memory Processing
University of Texas Southwestern Medical Center
NCT05594017
Intracranial Investigation of Neural Circuity Underlying Human Mood
Baylor College of Medicine
NCT05871372
Hippocampal Oscillations During Exploration
NYU Langone Health
NCT07224191
Capturing Autobiographical Memory Formation in Real World Spaces Using Multimodal Recordings
University of Utah
NCT06883981
Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Stanford University
NCT05996900
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 23 |
| Phase 2 | 16 |
| Phase 3 | 14 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Epilepsy records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Epilepsy trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Epilepsy page
164 registered trials, 78 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 78 Epilepsy trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Neurological Disorders and Stroke (NINDS) sponsors the most Epilepsy trials on record, review their full trial history before evaluating a specific study. See National Institute of Neurological Disorders and Stroke (NINDS)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Epilepsy condition card totals 164 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.