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ClinicalTrials.gov 78 recruiting now official registry

Epilepsy clinical trials

78 of 164 indexed Epilepsy trials are currently recruiting.

164 US clinical trials · 78 currently recruiting

Epilepsy is the subject of 164 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 39 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 9 of these trials.

The research picture

Epilepsy has 164 registered US clinical trials, 78 of them open to new participants right now, about 48% of the total.

78
recruiting participants now
48%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
9
top sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Phase 123Phase 216Phase 314Phase 47

Active & Recent Trials

164 total, page 1 of 4

RECRUITING 100,000 participants

Epilepsy Learning Healthcare System (ELHS)

Epilepsy Foundation of America

NCT06265103

RECRUITING 20,000 participants

De-identified UNMH EEG Corpus Database Creation With Fully De-identified Clinical Information

University of New Mexi

NCT05140265

RECRUITING 5,000 participants

Genetics of Epilepsy and Related Disorders

Boston Children's Hospital

NCT01858285

RECRUITING 5,000 participants

Physiological Brain Atlas Development

Vanderbilt University Medical Center

NCT00575081

RECRUITING 3,500 participants

Human Epilepsy Genetics--Neuronal Migration Disorders Study

Harvard University Faculty of Medicine

NCT00041600

RECRUITING 1,000 participants

Investigating Epilepsy: Screening and Evaluation

National Institute of Neurological Disorders and Stroke (NINDS)

NCT03478852

RECRUITING 1,000 participants

Patterns of Neurodevelopmental Disorders

Richard Frye

NCT06213090

RECRUITING 700 participants

Registry and Natural History of Epilepsy-Dyskinesia Syndromes

Boston Children's Hospital

NCT06967727

RECRUITING 700 participants

Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02107989

RECRUITING 600 participants

Genetic Markers of Cardiovascular Disease in Epilepsy

Mayo Clinic

NCT02824822

RECRUITING 500 participants

A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes

Boston Children's Hospital

NCT06585605

RECRUITING 500 participants

Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders

Southwest Autism Research & Resource Center

NCT04322734

RECRUITING NA 335 participants

Carbon Dioxide (CO2) Chemosensitivity and SUDEP

University of Iowa

NCT04134754

RECRUITING 300 participants

Surgery as a Treatment for Medically Intractable Epilepsy

National Institute of Neurological Disorders and Stroke (NINDS)

NCT01273129

RECRUITING Early Phase 1 290 participants

Localizing Epileptic Networks Using MRI and iEEG

University of Pennsylvania

NCT04649008

RECRUITING Phase 4 226 participants

Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits

VA Office of Research and Development

NCT04419272

RECRUITING 210 participants

Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

Epiminder America

NCT07110454

RECRUITING NA 205 participants

Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive Variables in Epilepsy Patients

Baylor College of Medicine

NCT05283811

RECRUITING NA 200 participants

AI-Based Mobile Intervention on Medication Non-Adherence and Transition

University of Central Florida

NCT07445074

RECRUITING NA 190 participants

Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy

Neuroelectrics Corporation

NCT04770337

RECRUITING NA 175 participants

Human Intracranial Electrophysiology

Dartmouth-Hitchcock Medical Center

NCT05529264

RECRUITING NA 170 participants

Cognitive Enhancement Intervention for Creating a Healthy L.I.F.E (Lifestyle Interventions for Epilepsy)

Kayela Arrotta

NCT05954182

RECRUITING 150 participants

MEHMO Natural History and Biomarkers

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT06019182

RECRUITING NA 144 participants

Research Evaluating Vagal Excitation AND Anatomical Links

University of Minnesota

NCT06143293

RECRUITING NA 120 participants

Telephone-Based Support Programs for People With Epilepsy

NYU Langone Health

NCT05082181

RECRUITING 100 participants

Tumor Related Epilepsy

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02639325

RECRUITING 100 participants

Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)

University of Missouri-Columbia

NCT07329257

RECRUITING NA 100 participants

Sleep Spindles and Memory in Rolandic Epilepsy

Massachusetts General Hospital

NCT04569708

RECRUITING NA 90 participants

Amygdala Memory Enhancement

Washington University School of Medicine

NCT05065450

RECRUITING 90 participants

Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG)

CREmedical

NCT05944692

RECRUITING 86 participants

ESIS in Pediatric DRE

Sarah Katie Ihnen

NCT05469373

RECRUITING NA 84 participants

Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing

Baylor College of Medicine

NCT05418894

RECRUITING NA 80 participants

Functional Brain Mapping for Patients with Epilepsy

Wayne State University

NCT05755919

RECRUITING NA 75 participants

Mapping of Human Cognition

The University of Texas Health Science Center, Houston

NCT05989893

RECRUITING NA 72 participants

Subcortical Arousal in Perceptual Awareness

Yale University

NCT06934356

RECRUITING Phase 1 72 participants

Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients

Suninflam

NCT07051629

RECRUITING Phase 3 70 participants

A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures

UCB Biopharma SRL

NCT04715646

RECRUITING NA 65 participants

Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System.

Epitel

NCT06027749

RECRUITING Phase 2 64 participants

Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study

Darcy Krueger

NCT05104983

RECRUITING NA 64 participants

Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery

Kayela Arrotta

NCT05992402

RECRUITING 60 participants

Physiological-based Pharmacokinetics Approach to Medication Exposure During Pregnancy and Breastfeeding

University of Pittsburgh

NCT05450978

RECRUITING NA 60 participants

Implementation and Cost Evaluation of Project UPLIFT

Emory University

NCT06865820

RECRUITING Phase 1 60 participants

A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy

Praxis Precision Medicines

NCT05737784

RECRUITING NA 60 participants

Collaborative Care for Anxiety and Depression in Epilepsy

Wake Forest University Health Sciences

NCT05559749

RECRUITING Phase 1 60 participants

Microelectrode Recordings From the Vagus Nerve in Awake Humans

University of Minnesota

NCT06016686

RECRUITING Early Phase 1 60 participants

Pharmacological Modulation of Brain Oscillations in Memory Processing

University of Texas Southwestern Medical Center

NCT05594017

RECRUITING NA 58 participants

Intracranial Investigation of Neural Circuity Underlying Human Mood

Baylor College of Medicine

NCT05871372

RECRUITING NA 56 participants

Hippocampal Oscillations During Exploration

NYU Langone Health

NCT07224191

RECRUITING NA 50 participants

Capturing Autobiographical Memory Formation in Real World Spaces Using Multimodal Recordings

University of Utah

NCT06883981

RECRUITING NA 49 participants

Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans

Stanford University

NCT05996900

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Phase Distribution

PhaseTrial count
Phase 1 23
Phase 2 16
Phase 3 14
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Epilepsy Trial Landscape

164 indexed Epilepsy studies · 78 recruiting (48%).

Phase mix: 21 late (III/IV) vs 39 early (I/II).

Top sponsor: National Institute of Neurological Disorders and Stroke (NINDS) (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Epilepsy?

PlainTrial tracks 164 US clinical trials for Epilepsy, of which 78 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Epilepsy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.