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NCT05375812 · ClinicalTrials.gov registry record

NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

A clinical trial of Gulf War Illness, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).

Recruiting
Registry status
85
Enrollment target
1
Study location

NCT05375812: Recruiting study of Gulf War Illness, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).

NCT05375812 is a study of Gulf War Illness that is actively recruiting participants, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 85 participants, below the 124-participant average among 14 other Gulf War Illness trials with a reported enrollment target (31% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05375812, a study of Gulf War Illness, is actively recruiting participants, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).

RECRUITING
Registry status
85 participants
Enrollment target
1
Study location

Study Summary

Background: Gulf War illness (GWI) affects up to 210,000 U.S. veterans who served in the Middle East during the Gulf War in 1990-1991. Symptoms include fatigue, muscle and joint pain, forgetfulness, headaches, rashes, and sleep disturbances. Routine exams cannot determine the cause of GWI. Researchers need more information to understand this disease. Objective: This natural history study will look for differences in Gulf War veterans who experienced GWI and those who did not. Eligibility: Gulf War veterans with GWI. Healthy Gulf War veterans who do not have GWI are also needed. Design: Participants will stay in the NIH Clinical Center as an inpatient for 2 weeks. They will undergo many tests. Blood will be drawn many times throughout the study. Participants will also give urine, saliva, and stool samples. Scans to measure the brain, leg muscles, bone density and body mass will be done. They will have an exercise stress test and muscle strength tests. They will have a sleep study. They will have tests to look at how well the brain, heart and lungs are working. Participants will sleep in a specialized room that measures the amount of oxygen they use and the carbon dioxide they produce on four consecutive nights. A sample of fluid will be collected from inside the spine. Participants will take many surveys. Some will ask about their activities. Some will be about emotional and mental health. Some will be about thinking, memory, and behavior. Optional tests include other imaging scans and testing the autonomic nervous system. Samples of skin and muscle may be taken. After discharge, participants will wear activity monitors for 14 days. They will keep a diary of their symptoms, including fatigue, pain, and sleep, while wearing the monitors.

Primary Outcome

Evaluate a number of clinical and biological measures.

Conditions Studied

Gulf War Illness

Study Locations (1)

Maryland

  • National Institutes of Health Clinical Center - Bethesda

Trial Details

FieldValue
Enrollment Target 85 participants
Start Date 2023-04-16
Est. Completion 2030-12-31
National Institute of Neurological Disorders and Stroke (NINDS)

567 total trials

What NCT05375812 shows while recruiting

NCT05375812 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 85 participants, a relatively small participant target, below the 124-participant average among 14 other Gulf War Illness trials with a reported enrollment target (31% lower).

The record links to 1 condition, with Gulf War Illness appearing as the primary indexed condition, and to 0 interventions.

NCT05375812 reports a single indexed study location in Maryland.

Frequently Asked Questions

What is clinical trial NCT05375812 about?

NCT05375812 is a clinical study titled "NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)". Background: Gulf War illness (GWI) affects up to 210,000 U.S. veterans who served in the Middle East during the Gulf War in 1990-1991. Symptoms include fatigue, muscle and joint pain, forgetfulness, headaches, rashes, and sleep disturbances. Routine exams cannot determine the cause of GWI. Research...

What is the current status of trial NCT05375812?

This trial is currently recruiting. The enrollment target is 85 participants. The study started on 2023-04-16. Estimated completion is 2030-12-31.

What conditions does trial NCT05375812 study?

This clinical trial studies the following conditions: Gulf War Illness.

Who is sponsoring clinical trial NCT05375812?

This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05375812 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Gulf War Illness

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05375812's enrollment target sits among peer trials

85 8th of 14 higher than 7 of 14 other Gulf War Illness trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Gulf War Illness trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05375812

Source: ClinicalTrials.gov NCT05375812, the US trial registry maintained by the National Library of Medicine. NCT05375812 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.