Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Motor Neuron Disease: early-phase trial registry
8 of 18 indexed Motor Neuron Disease trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #953 of 28,707 conditions by registered trial count.
18 US clinical trials · 8 currently recruiting · #953 of 28,707 conditions by registered trial count
Motor Neuron Disease: 18 US clinical trials tracked, 8 recruiting.
Motor Neuron Disease is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 6 of these trials.
Enrollment posture brief
Registry condition motor-neuron-disease
OPEN 8 | RECR 44% | LATE 0 | EARLY 2 | RANK #953 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Acute Ischemic Stroke (44% recruiting · 27 trials)
Motor Neuron Disease lists 8 open slots (44% of 18 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Motor Neuron Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Motor Neuron Disease is recruiting below its size-band peers.
8 of 18 indexed trials (44.4%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Motor Neuron Disease research.
National Institute of Neurological Disorders and Stroke (NINDS) accounts for 6 of 18 trials (33.3%). 12 distinct sponsors appear on at least one study for this condition label.
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Typical Motor Neuron Disease enrolment sits around 100 participants.
Median target enrolment is 100 among the 18 trials that report a genuine target (sentinel values excluded). 9 of those (50%) plan for fewer than 100 participants.
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Motor Neuron Disease research leans observational.
4 interventional and 14 observational studies make up this index (22.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
18 total, page 1 of 1
Study of Inherited Neurological Disorders
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00004568
ALS Research Collaborative
ALS Therapy Development Institute
NCT06885918
Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures
Target ALS Foundation
NCT05137665
Novel MRI Biomarkers for Monitoring Disease Progression in ALS
University of Alberta
NCT03362658
Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers
National Institute of Neurological Disorders and Stroke (NINDS)
NCT01900132
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)
Boston Children's Hospital
NCT05354622
Non-invasive BCI-controlled Assistive Devices
University of Texas at Austin
NCT05183152
Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)
National Institute of Neurological Disorders and Stroke (NINDS)
NCT04944940
Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)
National Institute of Neurological Disorders and Stroke (NINDS)
NCT07204977
Ultrasound and Videofluoroscopy for Diagnosing Swallowing Disorders
National Institutes of Health Clinical Center (CC)
NCT00001220
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases
Nemours Children's Clinic
NCT02532244
Brain Function in Primary Lateral Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00071435
Deep Phenotyping in Patients With ALS
Barrow Neurological Institute
NCT02819765
Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patient Population
Drexel University College of Medicine
NCT00718497
Efficacy of Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)
Columbia University
NCT00537641
Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease
Duke University
NCT00324454
Cerebrospinal Fluid Repository
Drexel University College of Medicine
NCT00714636
Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study
National Institute of Neurological Disorders and Stroke (NINDS)
NCT01143428
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Motor Neuron Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Motor Neuron Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Motor Neuron Disease page
18 registered trials, 8 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 8 Motor Neuron Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Neurological Disorders and Stroke (NINDS) sponsors the most Motor Neuron Disease trials on record, review their full trial history before evaluating a specific study. See National Institute of Neurological Disorders and Stroke (NINDS)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Motor Neuron Disease condition card totals 18 registered trials; most-linked intervention sample collection; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.