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NCT04312126 · ClinicalTrials.gov registry record
The Beneficial Effects of Naps on Motor Learning
A clinical trial of Stroke, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Recruiting
- Registry status
- 199
- Enrollment target
- 1
- Study location
NCT04312126: Recruiting study of Stroke, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT04312126 is a study of Stroke that is actively recruiting participants, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 199 participants, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04312126, a study of Stroke, is actively recruiting participants, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- RECRUITING
- Registry status
- 199 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows that daytime naps improve people s motor performance and memory retention. Researchers want to find out how daytime naps may contribute to learning and support consolidation of motor skill memories. Objective: To learn the role of memory replay during wakeful rest and sleep (naps) in retaining a newly learned skill. Eligibility: English-speaking adults ages 18 and older with chronic stroke, or healthy, right-handed, English-speaking adults ages 18-35 and 50-80 Design: Participants will be screened with: * medical history * neurological history * medicine review * medical exam * neurological exam. Participants will have a magnetic resonance imaging (MRI) scan of the brain. For this, they will lie down in a scanner. The scanner makes loud noises, so they will wear earplugs. They will fill out an MRI screening form before each MRI. Participants will also have magnetoencephalography (MEG). MEG maps brain activity. It does this by recording the magnetic fields produced by naturally occurring electrical currents in the brain. For MEG, participants will lie down in the MEG room. Their eye movements may be recorded by a video camera. Participants will have behavior testing. They will practice typing random keys. Then they will repeatedly type a custom sequence that they see on a computer screen. Then they will take a 2-hour nap. Then they will type the same sequence again. Participants will have no more than 4 visits at the NIH over 3 months. Visits will last 2-4 hours each.
Primary Outcome
The primary endpoint measure is the degree to which motor skill consolidation (i.e., offline change in correct sequence typing speed) is predicted by replay rates during wakeful rest and sleep, and spindle rates during sleep (i.e. multiple regression model with 3 predictors).
Conditions Studied
Interventions
- DEVICE MRI system
- DEVICE MEG system
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 199 participants |
| Start Date | 2021-03-04 |
| Est. Completion | 2026-08-01 |
What NCT04312126 shows while recruiting
NCT04312126 is an observational study that tracks outcomes without assigning an intervention. The registered 199 participants enrollment target is mid-sized for trials with a published cap, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Stroke appearing as the primary indexed condition, and to 2 interventions - of which MRI system is the first listed.
NCT04312126 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT04312126 about?
NCT04312126 is a clinical study titled "The Beneficial Effects of Naps on Motor Learning". Background: Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows that daytime naps improve people s motor performance and memory retention. Researchers want to find ou...
What is the current status of trial NCT04312126?
This trial is currently recruiting. The enrollment target is 199 participants. The study started on 2021-03-04. Estimated completion is 2026-08-01.
What conditions does trial NCT04312126 study?
This clinical trial studies the following conditions: Stroke.
What interventions are being tested in trial NCT04312126?
The interventions under investigation include: MRI system (DEVICE), MEG system (DEVICE).
Who is sponsoring clinical trial NCT04312126?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04312126 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04312126's enrollment target sits among peer trials
199 101st of 454 higher than 354 of 454 other Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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