Mclean Hospital
Mclean Hospital sponsors 140 registered US clinical trials on ClinicalTrials.gov, 26 of them currently recruiting, and 92 completed. 13 of these trials are in Phase 3-4 (later-stage) and 40 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Major Depressive Disorder, with 9 trials.
Trial Pipeline
140 total, page 1 of 3
A Pilot Trial of One-Day Accelerated TMS and D-cycloserine in Suicidal Patients With Borderline Personality Disorder
NCT07460947
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression
NCT07560878
Identifying Substance Use Consequences
NCT07503067
Stress Dynamics and Familial Risk for Depression in Female Adolescents
NCT06816329
Pharmacologic Augmentation of TMS for Depression With D-serine
NCT06876129
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation
NCT05232032
Mechanisms of Exposure Therapy for OCD
NCT06173752
Cerebellar Modulation of Cognition in Psychosis
NCT06107764
MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
NCT06191965
Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
NCT06221852
Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis
NCT06477406
Enhanced Coordinated Specialty Care for Early Psychosis
NCT06071858
Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder
NCT05837104
Following Outcomes Remotely Within Addiction Recovery Domains
NCT06001437
Role of Parent Interpretation Bias in the Transmission of Anxiety to Children
NCT05665491
Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder
NCT05457465
Individually Targeted Neuromodulation for Contamination-based OCD
NCT05048251
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
NCT05245903
Interpretation Bias as a Mechanism of Treatment Response in OCD
NCT05224414
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia
NCT04430517
Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
NCT05630963
Mechanisms and Predictors of Change in App-Based Mindfulness Training for Adolescents
NCT04697966
Using Transcranial Magnetic Stimulation (TMS) to Understand Hallucinations in Schizophrenia
NCT05343598
Neural Correlates of Stress and Perceived Control in Adolescent Depression
NCT04788524
Early Life Stress and Depression: Molecular and Functional Imaging
NCT04713722
Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia
NCT04075435
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Study 1.2 (Stress Manipulation)
NCT04325529
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression
NCT03484494
Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis
NCT07503093
Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder
NCT07593222
Non-Steroidal Anti-Inflammatory Drug (NSAID) Response and Central Sensitization of Pain in Women With Dysmenorrhea
NCT05900336
Effectiveness of HabitWorks and Symptom Tracking for Anxiety and Depression
NCT07025486
Women's Opioid Treatment Follow-up Study
NCT05776966
A Clinical Trial of a Hemp-Derived, High Cannabidiol Product for Anxiety in Glioblastoma Patients
NCT05753007
Psychoeducational Videos and Digital Assessments for BPD
NCT05358925
Online Emotional Response to Completing a Childhood Maltreatment Self-report Scale
NCT06152549
SMART Trial to Predict Anhedonia Response to Antidepressant Treatment
NCT05537584
Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study
NCT05380583
A Mobile Executive Functioning Intervention for Momentary Craving in Opioid Use Disorders
NCT05086835
Effects of Attention Training Interventions on Depression
NCT04184206
Detecting Drugs of Abuse Via Exhaled Breath Samples Using Differential Mobility Spectrometry
NCT05384470
Pain, Inflammation and Opioid Craving
NCT04190563
A Clinical Trial of a Hemp-Derived Cannabidiol Product for Anxiety
NCT04286594
Implementation of the Care Ecosystem Training Model for Individuals With Dementia in a High-risk, Integrated Care Management
NCT04556097
Behavioral and Neural Phenotypes of Primary Dysmenorrhea in Adolescents
NCT04685343
Families With Substance Use and Psychosis: A Pilot Study
NCT04284813
Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression
NCT04239963
Novel Cross-Species Neurophysiological Assays of Reward and Cognitive Domains
NCT02855229
Biomarkers of Response to Treatment With Frontal Cortex Stimulation for Anxious Depression
NCT03999736
Decision Making, Daily Experiences, and Brain Activity in Young Adult Women
NCT04125589
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 21 |
| Phase 3 | 3 |
| Phase 4 | 10 |
Therapeutic Areas
What the Pipeline for Mclean Hospital Shows
According to the ClinicalTrials.gov registry, Mclean Hospital is linked to 140 US clinical trials across every stage of research activity. Of those, 26 studies are currently recruiting, about 19% of the sponsor's indexed portfolio, and 92 are already marked complete, representing roughly 66% of the total.
The phase mix for Mclean Hospital reports 13 late-stage studies (Phase 3 and Phase 4 combined) and 40 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Mclean Hospital is Major Depressive Disorder with 9 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.