Mclean Hospital

140 total trials 26 currently recruiting 92 completed

Mclean Hospital sponsors 140 registered US clinical trials on ClinicalTrials.gov, 26 of them currently recruiting, and 92 completed. 13 of these trials are in Phase 3-4 (later-stage) and 40 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Major Depressive Disorder, with 9 trials.

Trial Pipeline

140 total, page 2 of 3

COMPLETED

Feasibility of Collateral Information Review and Its Impact on Clinical Decision-Making

NCT04635748

TERMINATED NA

Electrophysiological Correlates of Cognition in Depression

NCT03998748

COMPLETED Phase 2

Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders

NCT03943537

COMPLETED NA

Stress Response in Opioid Use Disorder

NCT03616379

COMPLETED NA

Cognitive Bias Modification for OCD

NCT03799419

COMPLETED NA

Augmenting Hospitalization for Serious Mental Illness: Cognitive Bias Modification

NCT03509181

COMPLETED NA

Electronic Media and Its Application in Psychotherapy

NCT03712267

TERMINATED NA

Cognitive Control Training for Urgency in a Naturalistic Clinical Setting

NCT03527550

COMPLETED Phase 2

Alkontrol-herbal Effects on Alcohol Drinking

NCT03099590

COMPLETED

Sex, Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in Depression

NCT03031665

TERMINATED Phase 4

The Effects of Nicotinamide Riboside Supplementation on Brain NAD+/NADH Ratio and Bioenergetics

NCT03151707

COMPLETED NA

McLean and Genomind Prospective Study

NCT03113890

COMPLETED

Brain Neurochemical Profile During Marijuana Abstinence

NCT04320537

COMPLETED NA

Hippocampal Plasticity of Young Adults With Childhood Adversity

NCT02816502

COMPLETED NA

Effects of Litebook EDGE™ Phototherapy on Academic Performance and Brain Activity

NCT05383690

COMPLETED Early Phase 1

Riluzole Effects on Hippocampus Biomarkers

NCT04630444

TERMINATED NA

LFMS: Initial Trial in Geriatric Bipolar Depression

NCT02707276

COMPLETED

Neuroimaging Studies of Reward Processing in Depression

NCT03026036

COMPLETED Phase 1

Cannabidiol Pharmacotherapy for Adults With Cannabis Use Disorder

NCT03102918

COMPLETED NA

Targeting Cerebellum to Treat Psychosis: a Transcranial Magnetic Stimulation (TMS) Study

NCT02642029

COMPLETED NA

Examining Reward-Related Predictors and Mechanisms of Change in BA Treatment for Anhedonic Adolescents

NCT02498925

COMPLETED Phase 1

Effect of Nicotine on Brain Reward Pathways

NCT02346539

COMPLETED Phase 4

Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients

NCT02188121

COMPLETED NA

Study of Treatment for Opioid Dependence and Anxiety Disorders

NCT02252068

COMPLETED NA

Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment

NCT02305537

TERMINATED Phase 2

A Trial of Intranasal Ketamine for the Treatment of Obsessive-Compulsive Disorder

NCT02234011

COMPLETED

Brain Mechanisms of Human Motivation

NCT01976975

COMPLETED Phase 1

An Investigation of Early Life Stress and Depression

NCT01701258

COMPLETED NA

Neural Mechanisms Underlying Nicotine and Alcohol Combinations

NCT02049268

COMPLETED NA

Psychoeducation of Borderline Patients

NCT01719731

COMPLETED NA

Multiple Treatment Study Using Low Field Magnetic Stimulation for Bipolar Depression

NCT01929681

TERMINATED NA

Spectroscopic Imaging at 4T: A Drug Challenge Study

NCT01577706

COMPLETED

Genetic and Neural Predictors of Adolescent Depression

NCT01743716

COMPLETED NA

Predicting Cognitive Resilience Against Sleep Loss

NCT01651429

TERMINATED Phase 1

D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS)

NCT01842334

COMPLETED

Brain Mechanisms of Emotion and Motivation: A Mind-Body Study

NCT01850472

COMPLETED Phase 2

Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders

NCT01720316

COMPLETED

Longitudinal Multimodal Neuroimaging Studies in Patients With First Episode Psychosis

NCT01688765

COMPLETED NA

Neural Components Underlying the Treatment of Adolescent Depression

NCT01717508

COMPLETED NA

Internet Based Cognitive Behavioral Therapy Effects on Depressive Cognitions and Brain Function

NCT01598922

COMPLETED NA

Assessing Models of Exposure Therapy

NCT01679457

TERMINATED

Functional and Neurochemical Correlates of Treatment Response in Major Depressive Disorder

NCT01598324

TERMINATED Phase 2

Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia

NCT01598896

COMPLETED Phase 4

Glutamatergic and GABAergic Mediators of Antidepressant Response in Major Depression

NCT01557946

COMPLETED

Simultaneous FMRI and NIRS to Estimate Brain Cerebral Metabolism

NCT01825096

COMPLETED Phase 1

The Effects of Dopamine on Reward Processing

NCT01253421

COMPLETED

Depression and Dopamine Transporter Function Study Using C-11 Altropane

NCT01701141

COMPLETED NA

Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar Depression

NCT01390389

COMPLETED NA

Treatment to Enhance Cognition in Bipolar Disorder

NCT01470781

COMPLETED

Dopamine Neurotransmission in Major Depression

NCT01659814

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Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 21
Phase 3 3
Phase 4 10

What the Pipeline for Mclean Hospital Shows

According to the ClinicalTrials.gov registry, Mclean Hospital is linked to 140 US clinical trials across every stage of research activity. Of those, 26 studies are currently recruiting, about 19% of the sponsor's indexed portfolio, and 92 are already marked complete, representing roughly 66% of the total.

The phase mix for Mclean Hospital reports 13 late-stage studies (Phase 3 and Phase 4 combined) and 40 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Mclean Hospital is Major Depressive Disorder with 9 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.