Mclean Hospital
Mclean Hospital sponsors 140 registered US clinical trials on ClinicalTrials.gov, 26 of them currently recruiting, and 92 completed. 13 of these trials are in Phase 3-4 (later-stage) and 40 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Major Depressive Disorder, with 9 trials.
Trial Pipeline
140 total, page 2 of 3
Feasibility of Collateral Information Review and Its Impact on Clinical Decision-Making
NCT04635748
Electrophysiological Correlates of Cognition in Depression
NCT03998748
Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders
NCT03943537
Stress Response in Opioid Use Disorder
NCT03616379
Cognitive Bias Modification for OCD
NCT03799419
Augmenting Hospitalization for Serious Mental Illness: Cognitive Bias Modification
NCT03509181
Electronic Media and Its Application in Psychotherapy
NCT03712267
Cognitive Control Training for Urgency in a Naturalistic Clinical Setting
NCT03527550
Alkontrol-herbal Effects on Alcohol Drinking
NCT03099590
Sex, Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in Depression
NCT03031665
The Effects of Nicotinamide Riboside Supplementation on Brain NAD+/NADH Ratio and Bioenergetics
NCT03151707
McLean and Genomind Prospective Study
NCT03113890
Brain Neurochemical Profile During Marijuana Abstinence
NCT04320537
Hippocampal Plasticity of Young Adults With Childhood Adversity
NCT02816502
Effects of Litebook EDGE™ Phototherapy on Academic Performance and Brain Activity
NCT05383690
Riluzole Effects on Hippocampus Biomarkers
NCT04630444
LFMS: Initial Trial in Geriatric Bipolar Depression
NCT02707276
Neuroimaging Studies of Reward Processing in Depression
NCT03026036
Cannabidiol Pharmacotherapy for Adults With Cannabis Use Disorder
NCT03102918
Targeting Cerebellum to Treat Psychosis: a Transcranial Magnetic Stimulation (TMS) Study
NCT02642029
Examining Reward-Related Predictors and Mechanisms of Change in BA Treatment for Anhedonic Adolescents
NCT02498925
Effect of Nicotine on Brain Reward Pathways
NCT02346539
Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients
NCT02188121
Study of Treatment for Opioid Dependence and Anxiety Disorders
NCT02252068
Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment
NCT02305537
A Trial of Intranasal Ketamine for the Treatment of Obsessive-Compulsive Disorder
NCT02234011
Brain Mechanisms of Human Motivation
NCT01976975
An Investigation of Early Life Stress and Depression
NCT01701258
Neural Mechanisms Underlying Nicotine and Alcohol Combinations
NCT02049268
Psychoeducation of Borderline Patients
NCT01719731
Multiple Treatment Study Using Low Field Magnetic Stimulation for Bipolar Depression
NCT01929681
Spectroscopic Imaging at 4T: A Drug Challenge Study
NCT01577706
Genetic and Neural Predictors of Adolescent Depression
NCT01743716
Predicting Cognitive Resilience Against Sleep Loss
NCT01651429
D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS)
NCT01842334
Brain Mechanisms of Emotion and Motivation: A Mind-Body Study
NCT01850472
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders
NCT01720316
Longitudinal Multimodal Neuroimaging Studies in Patients With First Episode Psychosis
NCT01688765
Neural Components Underlying the Treatment of Adolescent Depression
NCT01717508
Internet Based Cognitive Behavioral Therapy Effects on Depressive Cognitions and Brain Function
NCT01598922
Assessing Models of Exposure Therapy
NCT01679457
Functional and Neurochemical Correlates of Treatment Response in Major Depressive Disorder
NCT01598324
Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia
NCT01598896
Glutamatergic and GABAergic Mediators of Antidepressant Response in Major Depression
NCT01557946
Simultaneous FMRI and NIRS to Estimate Brain Cerebral Metabolism
NCT01825096
The Effects of Dopamine on Reward Processing
NCT01253421
Depression and Dopamine Transporter Function Study Using C-11 Altropane
NCT01701141
Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar Depression
NCT01390389
Treatment to Enhance Cognition in Bipolar Disorder
NCT01470781
Dopamine Neurotransmission in Major Depression
NCT01659814
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 21 |
| Phase 3 | 3 |
| Phase 4 | 10 |
Therapeutic Areas
What the Pipeline for Mclean Hospital Shows
According to the ClinicalTrials.gov registry, Mclean Hospital is linked to 140 US clinical trials across every stage of research activity. Of those, 26 studies are currently recruiting, about 19% of the sponsor's indexed portfolio, and 92 are already marked complete, representing roughly 66% of the total.
The phase mix for Mclean Hospital reports 13 late-stage studies (Phase 3 and Phase 4 combined) and 40 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Mclean Hospital is Major Depressive Disorder with 9 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.