Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 76 recruiting now official registry

Schizophrenia clinical trials

76 of 318 indexed Schizophrenia trials are currently recruiting.

318 US clinical trials · 76 currently recruiting

Schizophrenia is the subject of 318 registered US clinical trials on ClinicalTrials.gov, 76 of them currently open to new participants. 90 are in Phase 3-4 (later-stage) and 87 in Phase 1-2 (earlier-stage). The most active sponsor is University of Maryland, Baltimore, running 14 of these trials.

The research picture

Schizophrenia has 318 registered US clinical trials, 76 of them open to new participants right now, about 24% of the total.

76
recruiting participants now
24%
of trials open to enrollment
90
in Phase 3–4 (later-stage)
14
top sponsor: University of Maryland, Baltimore
Phase 147Phase 240Phase 350Phase 440

Active & Recent Trials

318 total, page 1 of 7

RECRUITING 1,500 participants

Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)

Bristol-Myers Squibb

NCT07379827

RECRUITING Phase 3 800 participants

NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia

Neurocrine Biosciences

NCT07114874

RECRUITING Phase 3 690 participants

Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia

Reviva Pharmaceuticals

NCT05184335

RECRUITING NA 600 participants

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

Massachusetts General Hospital

NCT04296604

RECRUITING Phase 4 524 participants

CLOZAPINE Response in Biotype-1

University of Texas Southwestern Medical Center

NCT04580134

RECRUITING Phase 3 522 participants

A Trial of the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants With Schizophrenia

Otsuka Pharmaceutical Development & Commercialization

NCT06894212

RECRUITING Phase 3 500 participants

Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

Intra-Cellular Therapies

NCT06229210

RECRUITING Phase 3 400 participants

Randomized Withdrawal Study in Patients With Schizophrenia

Vanda Pharmaceuticals

NCT06961968

RECRUITING NA 350 participants

Enhanced Coordinated Specialty Care for Early Psychosis

Mclean Hospital

NCT06071858

RECRUITING Phase 3 330 participants

Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia

Gedeon Richter

NCT03817502

RECRUITING 320 participants

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

Beth Israel Deaconess Medical Center

NCT06740383

RECRUITING NA 300 participants

Taking Action for College Students

Temple University

NCT06700902

RECRUITING Phase 2 300 participants

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Inpatient Adults With Schizophrenia

MapLight Therapeutics

NCT07038876

RECRUITING 300 participants

Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

Bristol-Myers Squibb

NCT07101094

RECRUITING Phase 3 284 participants

NBI-1117568-SCZ3030: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

Neurocrine Biosciences

NCT07105098

RECRUITING Phase 3 284 participants

NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

Neurocrine Biosciences

NCT06963034

RECRUITING Phase 4 280 participants

Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

New York State Psychiatric Institute

NCT05208190

RECRUITING Phase 3 280 participants

An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia

Karuna Therapeutics

NCT05304767

RECRUITING Phase 2 268 participants

A Study to Assess Adverse Events, Change in Disease Activity, and How Oral Emraclidine Moves Through the Body in Adult Participants With Schizophrenia

AbbVie

NCT07145918

RECRUITING Phase 3 220 participants

Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder

Alkermes

NCT05303064

RECRUITING Phase 1 215 participants

Genetics of Cannabis Use Disorder and Cannabinoid Response in Humans

Yale University

NCT06058702

RECRUITING NA 200 participants

Song-making In a Group (SING)

Yale University

NCT05929352

RECRUITING NA 200 participants

Cerebellar Stimulation and Cognitive Control

Krystal Parker, PhD

NCT03217110

RECRUITING NA 200 participants

Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Auditory Stimulation

Fabio Ferrarelli

NCT05956951

RECRUITING NA 190 participants

CBT-CP for Veterans With SMI

VA Office of Research and Development

NCT06758414

RECRUITING Phase 2 180 participants

Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

Brigham and Women's Hospital

NCT06376734

RECRUITING Phase 3 166 participants

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)

Bristol-Myers Squibb

NCT07288567

RECRUITING NA 160 participants

Medial-prefrontal Enhancement During Schizophrenia Systems Imaging

University of California, San Francisco

NCT04807530

RECRUITING NA 160 participants

Effects of Brain Stimulation on Cognition, Oscillations and GABA Levels in Schizophrenia

University of California, Davis

NCT04267003

RECRUITING Phase 1 160 participants

Cromoglicate Adjunctive Therapy for Outpatients With Schizophrenia

Vishwajit Nimgaonkar, MD PhD

NCT03794076

RECRUITING Phase 2 142 participants

Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia

Novartis Pharmaceuticals

NCT07467993

RECRUITING NA 140 participants

Neuronal Effects of Exercise in Schizophrenia

University of Colorado, Denver

NCT02455193

RECRUITING Phase 1 140 participants

Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder

BioXcel Therapeutics

NCT05025605

RECRUITING NA 120 participants

Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 1)

The University of Texas Health Science Center, Houston

NCT06345963

RECRUITING NA 120 participants

Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 2)

The University of Texas Health Science Center, Houston

NCT06961916

RECRUITING NA 120 participants

Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

Massachusetts General Hospital

NCT04940663

RECRUITING NA 112 participants

Exercise-based Program for Rehabilitation of Veterans With Severe Mental Illness

VA Office of Research and Development

NCT05157620

RECRUITING Phase 4 105 participants

Anticholinergic Deprescription in Schizophrenia

Deepak K. Sarpal, M.D.

NCT06562608

RECRUITING NA 104 participants

Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations

Boston VA Research Institute

NCT05299749

RECRUITING NA 100 participants

Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode

University of California, Los Angeles

NCT05890183

RECRUITING NA 100 participants

iTBS to Enhance Social Cognition in People With Psychosis

Northwell Health

NCT06118268

RECRUITING 100 participants

Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

Yale University

NCT01730781

RECRUITING Phase 4 100 participants

Safety and Tolerability of Open-Labeled Iloperidone in Adolescents

Vanda Pharmaceuticals

NCT05648591

RECRUITING NA 100 participants

Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility

Kai Hwang

NCT07217652

RECRUITING NA 100 participants

Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia

Vanderbilt University Medical Center

NCT07196462

RECRUITING NA 95 participants

Cerebellar Modulation of Cognition in Psychosis

Mclean Hospital

NCT06107764

RECRUITING NA 90 participants

Promoting Activity and Cognitive Enrichment in Schizophrenia (PACES)

University of Pittsburgh

NCT04143126

RECRUITING Phase 2 82 participants

Study of ALTO-101 in Patients With Schizophrenia

Alto Neuroscience

NCT06502964

RECRUITING NA 80 participants

Effectiveness of Motivation Skills Training (MST)

Columbia University

NCT05805397

RECRUITING NA 80 participants

Enhancing Rehabilitation for Veterans With Serious Mental Illness

VA Office of Research and Development

NCT06586164

Page 1 of 7 Next →

Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 40
Phase 3 50
Phase 4 40

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Schizophrenia Trial Landscape

318 indexed Schizophrenia studies · 76 recruiting (24%).

Phase mix: 90 late (III/IV) vs 87 early (I/II).

Top sponsor: University of Maryland, Baltimore (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Schizophrenia?

PlainTrial tracks 318 US clinical trials for Schizophrenia, of which 76 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Schizophrenia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.