Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Schizoaffective Disorder

Open-data reference.

83 US clinical trials · 19 currently recruiting

Active & Recent Trials

RECRUITING Phase 4 524 participants

CLOZAPINE Response in Biotype-1

University of Texas Southwestern Medical Center

NCT04580134

RECRUITING NA 350 participants

Enhanced Coordinated Specialty Care for Early Psychosis

Mclean Hospital

NCT06071858

RECRUITING 320 participants

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

Beth Israel Deaconess Medical Center

NCT06740383

RECRUITING Phase 4 280 participants

Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

New York State Psychiatric Institute

NCT05208190

RECRUITING NA 201 participants

Randomized Clinical Trial of iTEST: A Blended Intervention Targeting Introspective Accuracy

University of California, San Diego

NCT07098169

RECRUITING NA 125 participants

Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness (R33)

University of California, San Diego

NCT06865937

RECRUITING NA 111 participants

Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders

University of Pittsburgh

NCT07043803

RECRUITING Phase 4 105 participants

Anticholinergic Deprescription in Schizophrenia

Deepak K. Sarpal, M.D.

NCT06562608

RECRUITING NA 100 participants

Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode

University of California, Los Angeles

NCT05890183

RECRUITING NA 95 participants

Cerebellar Modulation of Cognition in Psychosis

Mclean Hospital

NCT06107764

RECRUITING NA 80 participants

Effectiveness of Motivation Skills Training (MST)

Columbia University

NCT05805397

RECRUITING NA 80 participants

Enhancing Rehabilitation for Veterans With Serious Mental Illness

VA Office of Research and Development

NCT06586164

RECRUITING NA 74 participants

Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study

Rutgers, The State University of New Jersey

NCT06745479

RECRUITING NA 60 participants

Prebiotic Treatment in People With Schizophrenia

University of Maryland, Baltimore

NCT05527210

RECRUITING Phase 4 50 participants

A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

Neurocrine Biosciences

NCT07105111

RECRUITING NA 50 participants

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

Mclean Hospital

NCT06221852

RECRUITING Phase 4 30 participants

Exercise and Olanzapine-samidorphan

New York State Psychiatric Institute

NCT06740890

RECRUITING NA 30 participants

Accelerated Transcranial Magnetic Stimulation for People With Schizophrenia Treated With Clozapine

Deepak K. Sarpal, M.D.

NCT06003036

RECRUITING Phase 4 10 participants

Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates

Corporal Michael J. Crescenz VA Medical Center

NCT03495024

ACTIVE NOT RECRUITING 1,000 participants

Database Registry for Neural Network Biomarkers in Psychosis

University of Texas Southwestern Medical Center

NCT01409109

ACTIVE NOT RECRUITING NA 200 participants

EPI-MINN: Targeting Cognition and Motivation - National

University of Minnesota

NCT05877716

ACTIVE NOT RECRUITING NA 49 participants

Optimizing CBSST With Executive Function Training for Schizophrenia

University of California, San Diego

NCT06251193

ACTIVE NOT RECRUITING Phase 2 30 participants

Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disorder

BioXcel Therapeutics

NCT07116694

COMPLETED 4,914 participants

Genetic Study of Schizophrenia

National Institute of Mental Health (NIMH)

NCT00001486

COMPLETED 800 participants

Neural Oscillations as Genetic and Functional Biomarkers in Normal and Disease States

University of Maryland, Baltimore

NCT01425671

COMPLETED Phase 3 667 participants

A Study to Evaluate the Efficacy of Paliperidone Palmitate in the Prevention of Relapse of the Symptoms of Schizoaffective Disorder

Janssen Scientific Affairs

NCT01193153

COMPLETED Phase 4 600 participants

Efficacy of High Dose Olanzapine for the Treatment of Schizophrenia and Schizoaffective Disorder

Eli Lilly and Company

NCT00100776

COMPLETED NA 461 participants

Improving Care and Reducing Cost Study

Northwell Health

NCT02364544

COMPLETED Phase 4 448 participants

Cognitive Skills Training Using Computer for Patients With Severe Mental Illness

Nathan Kline Institute for Psychiatric Research

NCT01036282

COMPLETED Phase 3 307 participants

Evaluation of Effectiveness and Safety of Flexible-dose Paliperidone Extended Release in Patients With Schizoaffective Disorder.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

NCT00412373

COMPLETED 283 participants

Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

National Institute of Mental Health (NIMH)

NCT00942981

COMPLETED Phase 3 244 participants

A Study Evaluating Lurasidone for The Treatment of Schizophrenia or Schizoaffective Disorder in Subjects Switched From Other Antipsychotic Agents

Sumitomo Pharma America

NCT01143077

COMPLETED NA 240 participants

The Appeal and Impact of E-cigarettes in Smokers With SMI

Dartmouth-Hitchcock Medical Center

NCT03050853

COMPLETED NA 238 participants

The Effectiveness of FMPO in Improving the Quality of Care for Persons With Severe Mental Illness.

US Department of Veterans Affairs

NCT00466323

COMPLETED Phase 1 218 participants

Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder

Otsuka Pharmaceutical Development & Commercialization

NCT01423916

COMPLETED NA 174 participants

Comparing Mobile Health (mHealth) and Clinic-Based Self-Management Interventions for Serious Mental Illness

Dartmouth-Hitchcock Medical Center

NCT02421965

COMPLETED NA 168 participants

Virtual Reality Job Interview Training in Severe Mental Illness

University of Michigan

NCT03049813

COMPLETED Phase 2 150 participants

Work Activity Augmented by Cognitive Rehabilitation for Schizophrenia

VA Office of Research and Development

NCT00430560

COMPLETED NA 149 participants

A New Paradigm for Illness Monitoring and Relapse Prevention in Schizophrenia

Dartmouth-Hitchcock Medical Center

NCT01952041

COMPLETED NA 122 participants

Personalized and Scalable Cognitive Remediation Approaches

New York State Psychiatric Institute

NCT01945333

COMPLETED NA 122 participants

Cognitive-Behavioral Therapy in Veterans With Schizophrenia

VA Office of Research and Development

NCT00688259

COMPLETED NA 120 participants

Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI

Dartmouth-Hitchcock Medical Center

NCT02334280

COMPLETED Phase 1 119 participants

Study Investigating the Effect of Lu AF35700 on Cardiac Repolarization in Men and Women With Schizophrenia and Schizoaffective Disorder

H. Lundbeck A/S

NCT02901587

COMPLETED NA 106 participants

A Study of Strategies to Improve Schizophrenia Treatment

US Department of Veterans Affairs

NCT00156637

COMPLETED Phase 3 104 participants

D-Serine Treatment of Negative Symptoms and Cognitive Deficits in Schizophrenia

Yale University

NCT00237809

COMPLETED Phase 2 97 participants

Nicotinic Receptors and Schizophrenia

University of Colorado, Denver

NCT01400477

COMPLETED NA 87 participants

Mobile Self-Tracking of Mental Health

VA Office of Research and Development

NCT05023252

COMPLETED NA 85 participants

Luteolin for the Treatment of People With Schizophrenia

University of Maryland, Baltimore

NCT05204407

COMPLETED NA 83 participants

Oxytocin and CBSST for People With Schizophrenia

University of Maryland, Baltimore

NCT01752712

COMPLETED Phase 2 76 participants

Cognitive - Behavioral Therapy

US Department of Veterans Affairs

NCT00018629

COMPLETED NA 69 participants

Cognitive Training for Patients With Schizophrenia

University of California, San Diego

NCT01521026

COMPLETED NA 67 participants

Improving Accessibility and Personalization of CR for Schizophrenia

New York State Psychiatric Institute

NCT03576976

COMPLETED NA 65 participants

Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia

Sheppard Pratt Health System

NCT01242371

COMPLETED Phase 4 64 participants

Determining the Effects of Risperdal Consta in Patients With Psychotic Disorders and Incomplete Adherence

Duke University

NCT00215579

COMPLETED Phase 2 62 participants

Memantine Augmentation of Targeted Cognitive Training in Schizophrenia

University of California, San Diego

NCT04857983

COMPLETED Phase 4 60 participants

The Effect of N-Acetyl Cysteine on Cortical Erosion in Early Stage Schizophrenia

Indiana University

NCT01339858

COMPLETED Phase 2 60 participants

High Dose of Quetiapine in Treating Subjects With Treatment Refractory Schizophrenia or Schizoaffective Disorder

Manhattan Psychiatric Center

NCT00297947

COMPLETED NA 51 participants

Development of a Mobile System for Self-management of Schizophrenia (SOS)

Dartmouth-Hitchcock Medical Center

NCT01969500

COMPLETED Phase 4 50 participants

Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder

University of Massachusetts, Worcester

NCT03526354

COMPLETED NA 50 participants

Omega-3 Dietary Supplements in Schizophrenia

Delbert Robinson

NCT01786239

COMPLETED NA 49 participants

Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness

University of Washington

NCT03062267

COMPLETED NA 48 participants

Enhancing Cognitive Training Through Exercise After a First Schizophrenia Episode

University of California, Los Angeles

NCT02267070

COMPLETED Phase 1 48 participants

A Study to Determine Pharmacokinetic Characteristics of LY03010 Versus INVEGA SUSTENNA® in Schizophrenia Patients

Luye Pharma Group

NCT03751488

COMPLETED Phase 1 47 participants

A Study of Aripiprazole Lauroxil in Subjects With Schizophrenia or Schizoaffective Disorder

Alkermes

NCT02636842

COMPLETED NA 40 participants

Texting for Relapse Prevention

Center for Innovative Public Health Research

NCT02819349

COMPLETED NA 32 participants

A Comparison of Two Cognitive Batteries in People With Schizophrenia

North Suffolk Mental Health Association

NCT00499044

COMPLETED NA 31 participants

Motivation and Skills Support (MASS)

Boston University Charles River Campus

NCT03404219

COMPLETED NA 30 participants

A Concierge Model of CAE Plus LAI in Individuals With Schizophrenia at Risk for Treatment Non-adherence and Homelessness

University Hospitals Cleveland Medical Center

NCT02085447

COMPLETED Phase 4 26 participants

Prebiotic Treatment in People With Schizophrenia - Pilot Study

University of Maryland, Baltimore

NCT03617783

COMPLETED Phase 4 25 participants

Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia

Massachusetts General Hospital

NCT00595504

COMPLETED NA 24 participants

Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia

Yale University

NCT00793780

COMPLETED NA 21 participants

Neuroendocrine and Immune Response to Stress in Schizophrenia

University of Maryland, Baltimore

NCT01975584

COMPLETED NA 20 participants

NST-SPARK: Preliminary Study of an Augmented Reality (AR) App Delivering Recovery-Oriented Cognitive Therapy for Negative Symptoms in Schizophrenia

North Shore Therapeutics

NCT06653829

COMPLETED Phase 4 20 participants

Galantamine for Cognition in People With Schizophrenia

North Suffolk Mental Health Association

NCT00320736

COMPLETED Phase 2 19 participants

Effects of Pentazocine Versus Lorazepam on Manic Symptoms

Mclean Hospital

NCT00431184

COMPLETED Phase 1 18 participants

M1 Schizophrenia PET Study

Yale University

NCT05105542

COMPLETED Phase 2 16 participants

Biomarkers in Schizophrenia

Nathan Kline Institute for Psychiatric Research

NCT00817336

COMPLETED Phase 1 16 participants

An Randomized Open-Label PK Study of LY03004 Compared to Risperdal® Consta® in Stable Patients With Schizophrenia or Schizoaffective Disorder

Luye Pharma Group

NCT02186769

COMPLETED 15 participants

Effects of Antipsychotic Medications on Energy Intake and Expenditure

Washington University School of Medicine

NCT00836251

COMPLETED NA 11 participants

Family-Directed Cognitive Adaptation Program for Individuals With Schizophrenia

Beth Israel Deaconess Medical Center

NCT00434980

COMPLETED NA 10 participants

eMove - Dance/Movement Therapy Study

Drexel University

NCT05712928

COMPLETED NA 9 participants

Improving Neurocognitive Deficits and Function in Schizophrenia With Transcranial Magnetic Stimulation

VA Office of Research and Development

NCT03037983

COMPLETED NA

Generalization of Training in Schizophrenia

US Department of Veterans Affairs

NCT00108199

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 8
Phase 3 4
Phase 4 14

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Schizoaffective Disorder Trial Landscape

ClinicalTrials.gov lists 83 US studies indexed under Schizoaffective Disorder, and 19 of those are currently open to recruitment — roughly 23% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Schizoaffective Disorder shows 18 late-stage studies (Phase 3 and Phase 4 combined) alongside 14 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Schizoaffective Disorder is led by University of Maryland, Baltimore with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 83 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Schizoaffective Disorder?

PlainTrial tracks 83 US clinical trials for Schizoaffective Disorder, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Schizoaffective Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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