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Schizoaffective Disorder
Open-data reference.
83 US clinical trials · 19 currently recruiting
Active & Recent Trials
CLOZAPINE Response in Biotype-1
University of Texas Southwestern Medical Center
NCT04580134
Enhanced Coordinated Specialty Care for Early Psychosis
Mclean Hospital
NCT06071858
Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services
Beth Israel Deaconess Medical Center
NCT06740383
Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial
New York State Psychiatric Institute
NCT05208190
Randomized Clinical Trial of iTEST: A Blended Intervention Targeting Introspective Accuracy
University of California, San Diego
NCT07098169
Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness (R33)
University of California, San Diego
NCT06865937
Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders
University of Pittsburgh
NCT07043803
Anticholinergic Deprescription in Schizophrenia
Deepak K. Sarpal, M.D.
NCT06562608
Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode
University of California, Los Angeles
NCT05890183
Cerebellar Modulation of Cognition in Psychosis
Mclean Hospital
NCT06107764
Effectiveness of Motivation Skills Training (MST)
Columbia University
NCT05805397
Enhancing Rehabilitation for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT06586164
Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study
Rutgers, The State University of New Jersey
NCT06745479
Prebiotic Treatment in People With Schizophrenia
University of Maryland, Baltimore
NCT05527210
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
Neurocrine Biosciences
NCT07105111
Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
Mclean Hospital
NCT06221852
Exercise and Olanzapine-samidorphan
New York State Psychiatric Institute
NCT06740890
Accelerated Transcranial Magnetic Stimulation for People With Schizophrenia Treated With Clozapine
Deepak K. Sarpal, M.D.
NCT06003036
Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates
Corporal Michael J. Crescenz VA Medical Center
NCT03495024
Database Registry for Neural Network Biomarkers in Psychosis
University of Texas Southwestern Medical Center
NCT01409109
EPI-MINN: Targeting Cognition and Motivation - National
University of Minnesota
NCT05877716
Optimizing CBSST With Executive Function Training for Schizophrenia
University of California, San Diego
NCT06251193
Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disorder
BioXcel Therapeutics
NCT07116694
Genetic Study of Schizophrenia
National Institute of Mental Health (NIMH)
NCT00001486
Neural Oscillations as Genetic and Functional Biomarkers in Normal and Disease States
University of Maryland, Baltimore
NCT01425671
A Study to Evaluate the Efficacy of Paliperidone Palmitate in the Prevention of Relapse of the Symptoms of Schizoaffective Disorder
Janssen Scientific Affairs
NCT01193153
Efficacy of High Dose Olanzapine for the Treatment of Schizophrenia and Schizoaffective Disorder
Eli Lilly and Company
NCT00100776
Improving Care and Reducing Cost Study
Northwell Health
NCT02364544
Cognitive Skills Training Using Computer for Patients With Severe Mental Illness
Nathan Kline Institute for Psychiatric Research
NCT01036282
Evaluation of Effectiveness and Safety of Flexible-dose Paliperidone Extended Release in Patients With Schizoaffective Disorder.
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
NCT00412373
Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography
National Institute of Mental Health (NIMH)
NCT00942981
A Study Evaluating Lurasidone for The Treatment of Schizophrenia or Schizoaffective Disorder in Subjects Switched From Other Antipsychotic Agents
Sumitomo Pharma America
NCT01143077
The Appeal and Impact of E-cigarettes in Smokers With SMI
Dartmouth-Hitchcock Medical Center
NCT03050853
The Effectiveness of FMPO in Improving the Quality of Care for Persons With Severe Mental Illness.
US Department of Veterans Affairs
NCT00466323
Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder
Otsuka Pharmaceutical Development & Commercialization
NCT01423916
Comparing Mobile Health (mHealth) and Clinic-Based Self-Management Interventions for Serious Mental Illness
Dartmouth-Hitchcock Medical Center
NCT02421965
Virtual Reality Job Interview Training in Severe Mental Illness
University of Michigan
NCT03049813
Work Activity Augmented by Cognitive Rehabilitation for Schizophrenia
VA Office of Research and Development
NCT00430560
A New Paradigm for Illness Monitoring and Relapse Prevention in Schizophrenia
Dartmouth-Hitchcock Medical Center
NCT01952041
Personalized and Scalable Cognitive Remediation Approaches
New York State Psychiatric Institute
NCT01945333
Cognitive-Behavioral Therapy in Veterans With Schizophrenia
VA Office of Research and Development
NCT00688259
Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI
Dartmouth-Hitchcock Medical Center
NCT02334280
Study Investigating the Effect of Lu AF35700 on Cardiac Repolarization in Men and Women With Schizophrenia and Schizoaffective Disorder
H. Lundbeck A/S
NCT02901587
A Study of Strategies to Improve Schizophrenia Treatment
US Department of Veterans Affairs
NCT00156637
D-Serine Treatment of Negative Symptoms and Cognitive Deficits in Schizophrenia
Yale University
NCT00237809
Nicotinic Receptors and Schizophrenia
University of Colorado, Denver
NCT01400477
Mobile Self-Tracking of Mental Health
VA Office of Research and Development
NCT05023252
Luteolin for the Treatment of People With Schizophrenia
University of Maryland, Baltimore
NCT05204407
Oxytocin and CBSST for People With Schizophrenia
University of Maryland, Baltimore
NCT01752712
Cognitive - Behavioral Therapy
US Department of Veterans Affairs
NCT00018629
Cognitive Training for Patients With Schizophrenia
University of California, San Diego
NCT01521026
Improving Accessibility and Personalization of CR for Schizophrenia
New York State Psychiatric Institute
NCT03576976
Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia
Sheppard Pratt Health System
NCT01242371
Determining the Effects of Risperdal Consta in Patients With Psychotic Disorders and Incomplete Adherence
Duke University
NCT00215579
Memantine Augmentation of Targeted Cognitive Training in Schizophrenia
University of California, San Diego
NCT04857983
The Effect of N-Acetyl Cysteine on Cortical Erosion in Early Stage Schizophrenia
Indiana University
NCT01339858
High Dose of Quetiapine in Treating Subjects With Treatment Refractory Schizophrenia or Schizoaffective Disorder
Manhattan Psychiatric Center
NCT00297947
Development of a Mobile System for Self-management of Schizophrenia (SOS)
Dartmouth-Hitchcock Medical Center
NCT01969500
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
University of Massachusetts, Worcester
NCT03526354
Omega-3 Dietary Supplements in Schizophrenia
Delbert Robinson
NCT01786239
Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness
University of Washington
NCT03062267
Enhancing Cognitive Training Through Exercise After a First Schizophrenia Episode
University of California, Los Angeles
NCT02267070
A Study to Determine Pharmacokinetic Characteristics of LY03010 Versus INVEGA SUSTENNA® in Schizophrenia Patients
Luye Pharma Group
NCT03751488
A Study of Aripiprazole Lauroxil in Subjects With Schizophrenia or Schizoaffective Disorder
Alkermes
NCT02636842
Texting for Relapse Prevention
Center for Innovative Public Health Research
NCT02819349
A Comparison of Two Cognitive Batteries in People With Schizophrenia
North Suffolk Mental Health Association
NCT00499044
Motivation and Skills Support (MASS)
Boston University Charles River Campus
NCT03404219
A Concierge Model of CAE Plus LAI in Individuals With Schizophrenia at Risk for Treatment Non-adherence and Homelessness
University Hospitals Cleveland Medical Center
NCT02085447
Prebiotic Treatment in People With Schizophrenia - Pilot Study
University of Maryland, Baltimore
NCT03617783
Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia
Massachusetts General Hospital
NCT00595504
Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia
Yale University
NCT00793780
Neuroendocrine and Immune Response to Stress in Schizophrenia
University of Maryland, Baltimore
NCT01975584
NST-SPARK: Preliminary Study of an Augmented Reality (AR) App Delivering Recovery-Oriented Cognitive Therapy for Negative Symptoms in Schizophrenia
North Shore Therapeutics
NCT06653829
Galantamine for Cognition in People With Schizophrenia
North Suffolk Mental Health Association
NCT00320736
Effects of Pentazocine Versus Lorazepam on Manic Symptoms
Mclean Hospital
NCT00431184
M1 Schizophrenia PET Study
Yale University
NCT05105542
Biomarkers in Schizophrenia
Nathan Kline Institute for Psychiatric Research
NCT00817336
An Randomized Open-Label PK Study of LY03004 Compared to Risperdal® Consta® in Stable Patients With Schizophrenia or Schizoaffective Disorder
Luye Pharma Group
NCT02186769
Effects of Antipsychotic Medications on Energy Intake and Expenditure
Washington University School of Medicine
NCT00836251
Family-Directed Cognitive Adaptation Program for Individuals With Schizophrenia
Beth Israel Deaconess Medical Center
NCT00434980
eMove - Dance/Movement Therapy Study
Drexel University
NCT05712928
Improving Neurocognitive Deficits and Function in Schizophrenia With Transcranial Magnetic Stimulation
VA Office of Research and Development
NCT03037983
Generalization of Training in Schizophrenia
US Department of Veterans Affairs
NCT00108199
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 4 |
| Phase 4 | 14 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Schizoaffective Disorder Trial Landscape
ClinicalTrials.gov lists 83 US studies indexed under Schizoaffective Disorder, and 19 of those are currently open to recruitment — roughly 23% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Schizoaffective Disorder shows 18 late-stage studies (Phase 3 and Phase 4 combined) alongside 14 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Schizoaffective Disorder is led by University of Maryland, Baltimore with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 83 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Schizoaffective Disorder?
PlainTrial tracks 83 US clinical trials for Schizoaffective Disorder, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Schizoaffective Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.