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NCT06876129 · ClinicalTrials.gov registry record · Phase 1

Pharmacologic Augmentation of TMS for Depression With D-serine

A Phase 1 study of Depression, sponsored by Mclean Hospital.

Recruiting
Registry status
Phase 1
Development phase
60
Enrollment target
1
Study location

NCT06876129 is a Phase 1 study of Depression that is actively recruiting participants, run by Mclean Hospital. The registered enrollment target is 60 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06876129, a Phase 1 study of Depression, is actively recruiting participants, sponsored by Mclean Hospital.

RECRUITING
Registry status
Phase 1
Development phase
60 participants
Enrollment target
1
Study location

Study Summary

The goal of this study is to test whether combining D-serine with 30 treatments of a) iTBS and b) 18-Hz protocols will enhance clinical outcomes compared to rTMS with placebo (i.e., sugar pill). The investigators hypothesize that NMDA receptor activation via D-serine combined with repeated sessions of rTMS will produce greater clinical outcomes than iTBS with placebo and 18-Hz with placebo.

Conditions Studied

Depression

Interventions

  • DEVICE TMS
  • COMBINATION_PRODUCT D-serine + TMS

Study Locations (1)

Massachusetts

  • McLean Hospital - Belmont

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2025-04-01
Est. Completion 2026-04-01
Phase Phase 1

Sponsor

Mclean Hospital

140 total trials

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What the Registry Record Tells You About NCT06876129

The ClinicalTrials.gov registry entry for NCT06876129 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 786-participant average among 679 other Depression trials with a reported enrollment target (92% lower). The listed sponsor is Mclean Hospital, which has 140 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Depression appearing as the primary indexed condition, and to 2 interventions - of which TMS is the first listed.

NCT06876129 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.

Frequently Asked Questions

What is clinical trial NCT06876129 about?

NCT06876129 is a clinical study titled "Pharmacologic Augmentation of TMS for Depression With D-serine". The goal of this study is to test whether combining D-serine with 30 treatments of a) iTBS and b) 18-Hz protocols will enhance clinical outcomes compared to rTMS with placebo (i.e., sugar pill). The investigators hypothesize that NMDA receptor activation via D-serine combined with repeated sessions ...

What is the current status of trial NCT06876129?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2025-04-01. Estimated completion is 2026-04-01.

What conditions does trial NCT06876129 study?

This clinical trial studies the following conditions: Depression.

What interventions are being tested in trial NCT06876129?

The interventions under investigation include: TMS (DEVICE), D-serine + TMS (COMBINATION_PRODUCT).

Who is sponsoring clinical trial NCT06876129?

This trial is sponsored by Mclean Hospital, which has 140 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06876129 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.