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Bipolar Depression: later-stage trial registry
8 of 30 indexed Bipolar Depression trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #519 of 28,707 conditions by registered trial count.
30 US clinical trials · 8 currently recruiting · #519 of 28,707 conditions by registered trial count
Bipolar Depression: 30 US clinical trials tracked, 8 recruiting.
Bipolar Depression is the subject of 30 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Intra-Cellular Therapies, running 4 of these trials.
Enrollment posture brief
Registry condition bipolar-depression
OPEN 8 | RECR 27% | LATE 12 | EARLY 5 | RANK #519 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Age-related Macular Degeneration (27% recruiting · 75 trials)
Bipolar Depression lists 8 open slots (27% of 30 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Bipolar Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Bipolar Depression is recruiting below its size-band peers.
8 of 30 indexed trials (26.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Bipolar Depression trials is spread across many organizations.
Intra-Cellular Therapies accounts for 4 of 30 trials (13.3%). 19 distinct sponsors appear on at least one study for this condition label.
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Typical Bipolar Depression enrolment sits around 80 participants.
Median target enrolment is 80 among the 30 trials that report a genuine target (sentinel values excluded). 16 of those (53.3%) plan for fewer than 100 participants.
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Bipolar Depression research is mostly interventional.
26 interventional and 4 observational studies make up this index (86.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
30 total, page 1 of 1
University of Iowa Interventional Psychiatry Service Patient Registry
Mark Niciu
NCT04480918
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
Xenon Pharmaceuticals
NCT07172516
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
Intra-Cellular Therapies
NCT06372964
RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
Mayo Clinic
NCT07266545
Ketogenic Intervention for Bipolar Depression
Mayo Clinic
NCT07121894
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
Massachusetts General Hospital
NCT03748446
Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression
Laureate Institute for Brain Research
NCT06088732
Deep Brain Stimulation of Treatment-Resistant Bipolar Depression
Wayne Goodman MD
NCT06599099
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Brigham and Women's Hospital
NCT03336918
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression
Mclean Hospital
NCT03484494
Focused Ultrasound Amygdala Neuromodulation
University of Texas at Austin
NCT05228964
Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:
Mayo Clinic
NCT03573349
Pediatric Open-Label Extension Study
Sumitomo Pharma America
NCT01914393
Seroquel in Bipolar Depression Versus SSRI
AstraZeneca
NCT00119652
Clinical Trial Evaluating ITI-007 (Lumateperone) as a Monotherapy for the Treatment of Bipolar Depression
Intra-Cellular Therapies
NCT02600494
Clinical Trial Evaluating ITI-007 as an Adjunctive Therapy to Lithium or Valproate for the Treatment of Bipolar Depression
Intra-Cellular Therapies
NCT02600507
Lumateperone Monotherapy for the Treatment of Bipolar Depression Conducted Globally
Intra-Cellular Therapies
NCT03249376
Lurasidone HCI - A 6-week Phase 3 Study of Patients With Bipolar I Depression
Sumitomo Pharma America
NCT01284517
Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Add-on)
Sumitomo Pharma America
NCT00868452
Low Field Magnetic Stimulation in Mood Disorders Using the LFMS Device
Mclean Hospital
NCT00578383
Mechanism of Action of Electroconvulsive Therapy
Massachusetts General Hospital
NCT04059952
Phase II Study to Assess RG2417 in the Treatment of Bipolar I Depression
Repligen Corporation
NCT00322764
Uridine Adolescent Bipolar Depression Randomized Controlled Trial
University of Utah
NCT01805440
Neuroimaging Studies of the Treatment of Bipolar Depression With Citalopram
Massachusetts General Hospital
NCT01639482
Vitamin D Supplementation for Bipolar Depression
University of Massachusetts, Worcester
NCT01884844
A Trial of SAMe for Treatment-Resistant Bipolar Depression
Mclean Hospital
NCT00762268
Biosignatures of Latuda for Bipolar Depression
New York State Psychiatric Institute
NCT02239094
FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression
Brian Barnett
NCT06620042
Minocycline for Bipolar Depression
Icahn School of Medicine at Mount Sinai
NCT01514422
Aripiprazole Treatment of Bipolar Depression
Indiana University School of Medicine
NCT00198198
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 2 |
| Phase 3 | 9 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Bipolar Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Bipolar Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Bipolar Depression page
30 registered trials, 8 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 8 Bipolar Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Intra-Cellular Therapies sponsors the most Bipolar Depression trials on record, review their full trial history before evaluating a specific study. See Intra-Cellular Therapies's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Bipolar Depression condition card totals 30 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.