Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Anhedonia: full-pipeline trial registry
12 of 22 indexed Anhedonia trials are currently recruiting.
Corpus placement: #756 of 28,707 conditions by registered trial count.
22 US clinical trials · 12 currently recruiting · #756 of 28,707 conditions by registered trial count
Anhedonia: 22 US clinical trials tracked, 12 recruiting.
Anhedonia is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Mclean Hospital, running 3 of these trials.
Enrollment posture brief
Registry condition anhedonia
OPEN 12 | RECR 55% | LATE 3 | EARLY 2 | RANK #756 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Advanced Ovarian Carcinoma (55% recruiting · 11 trials)
Anhedonia lists 12 open slots (55% of 22 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Anhedonia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Anhedonia is recruiting above its size-band peers.
12 of 22 indexed trials (54.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Anhedonia trials is spread across many organizations.
Mclean Hospital accounts for 3 of 22 trials (13.6%). 14 distinct sponsors appear on at least one study for this condition label.
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Most Anhedonia trials plan to enrol fewer than 100 people.
Median target enrolment is 78 among the 22 trials that report a genuine target (sentinel values excluded). 14 of those (63.6%) plan for fewer than 100 participants.
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Anhedonia research is mostly interventional.
18 interventional and 4 observational studies make up this index (81.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
22 total, page 1 of 1
Stress Trajectories and Anhedonia in Adolescence Research Study
University of North Carolina, Chapel Hill
NCT07040449
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
San Francisco Veterans Affairs Medical Center
NCT06080646
Psychotherapy Effects on Reward Processing in PTSD
University of Texas at Austin
NCT06096740
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
University of North Carolina, Chapel Hill
NCT05282277
Geolocation Positional System (GPS) Experience
University of Miami
NCT05991713
Reward Processing and Exposure Therapy for Social Anxiety Disorder
University of California, Los Angeles
NCT06776991
A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide
Ksana Health
NCT05920252
Get ActivE Study for At-risk Youth
University of Pittsburgh
NCT06829953
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Florida State University
NCT06132581
Dopaminergic Therapy for Anhedonia - 2
Emory University
NCT06075771
Inflammation and Depression in People With HIV
Emory University
NCT05849038
Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression
The University of Texas Health Science Center, Houston
NCT05240352
Psilocybin for Treatment-Resistant Depression
University of Colorado, Denver
NCT06230757
Optimizing a Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
Ksana Health
NCT06665620
A Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
Janssen Research & Development
NCT05550532
Text Based Digital Interventions Prompting Enjoyable and Healthy Behaviors
Florida State University
NCT06492824
Depression and Dopamine Transporter Function Study Using C-11 Altropane
Mclean Hospital
NCT01701141
Brain Mechanisms of Emotion and Motivation: A Mind-Body Study
Mclean Hospital
NCT01850472
Family Promoting Positive Emotions Pilot Study
Vanderbilt University
NCT05223842
Dopamine Neurotransmission in Major Depression
Mclean Hospital
NCT01659814
Development of a Novel Transdiagnostic Intervention for Anhedonia - R61 Phase
University of North Carolina, Chapel Hill
NCT02874534
Investigating LIFUP in Anhedonic Depression
University of California, Los Angeles
NCT06285474
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 3 | 1 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Anhedonia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Anhedonia trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Anhedonia page
22 registered trials, 12 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 12 Anhedonia trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Mclean Hospital sponsors the most Anhedonia trials on record, review their full trial history before evaluating a specific study. See Mclean Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Anhedonia condition card totals 22 registered trials; most-linked intervention Placebo; top US site state Florida. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.