Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Anhedonia clinical trials
Every US clinical trial registered for Anhedonia — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
22 US clinical trials · 12 currently recruiting
The research picture
Anhedonia has 22 registered US clinical trials, 12 of them open to new participants right now — about 55% of the total.
- 12
- recruiting participants now
- 55%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Mclean Hospital
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Stress Trajectories and Anhedonia in Adolescence Research Study
University of North Carolina, Chapel Hill
NCT07040449
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
San Francisco Veterans Affairs Medical Center
NCT06080646
Psychotherapy Effects on Reward Processing in PTSD
University of Texas at Austin
NCT06096740
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
University of North Carolina, Chapel Hill
NCT05282277
Geolocation Positional System (GPS) Experience
University of Miami
NCT05991713
Reward Processing and Exposure Therapy for Social Anxiety Disorder
University of California, Los Angeles
NCT06776991
A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide
Ksana Health
NCT05920252
Get ActivE Study for At-risk Youth
University of Pittsburgh
NCT06829953
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Florida State University
NCT06132581
Dopaminergic Therapy for Anhedonia - 2
Emory University
NCT06075771
Inflammation and Depression in People With HIV
Emory University
NCT05849038
Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression
The University of Texas Health Science Center, Houston
NCT05240352
Psilocybin for Treatment-Resistant Depression
University of Colorado, Denver
NCT06230757
Optimizing a Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
Ksana Health
NCT06665620
A Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
Janssen Research & Development
NCT05550532
Text Based Digital Interventions Prompting Enjoyable and Healthy Behaviors
Florida State University
NCT06492824
Depression and Dopamine Transporter Function Study Using C-11 Altropane
Mclean Hospital
NCT01701141
Brain Mechanisms of Emotion and Motivation: A Mind-Body Study
Mclean Hospital
NCT01850472
Family Promoting Positive Emotions Pilot Study
Vanderbilt University
NCT05223842
Dopamine Neurotransmission in Major Depression
Mclean Hospital
NCT01659814
Development of a Novel Transdiagnostic Intervention for Anhedonia - R61 Phase
University of North Carolina, Chapel Hill
NCT02874534
Investigating LIFUP in Anhedonic Depression
University of California, Los Angeles
NCT06285474
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 3 | 1 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Anhedonia Trial Landscape
ClinicalTrials.gov lists 22 US studies indexed under Anhedonia, and 12 of those are currently open to recruitment — roughly 55% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Anhedonia shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Anhedonia is led by Mclean Hospital with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 22 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Anhedonia?
PlainTrial tracks 22 US clinical trials for Anhedonia, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Anhedonia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.