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NCT04788524 · ClinicalTrials.gov registry record · NA
Neural Correlates of Stress and Perceived Control in Adolescent Depression
A NA study of Major Depressive Disorder, sponsored by Mclean Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT04788524: Recruiting NA study of Major Depressive Disorder, sponsored by Mclean Hospital.
NCT04788524 is a NA study of Major Depressive Disorder that is actively recruiting participants, run by Mclean Hospital. The registered enrollment target is 80 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (79% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04788524, a NA study of Major Depressive Disorder, is actively recruiting participants, sponsored by Mclean Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.
Primary Outcome
BOLD activation of frontostriatal regions in response to computer tasks performed during the fMRI Brian scan
Conditions Studied
Interventions
- BEHAVIORAL Computer Task Manipulation
Study Locations (1)
Massachusetts
- McLean Hospital - Belmont
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2021-04-23 |
| Est. Completion | 2026-04-30 |
| Phase | NA |
What NCT04788524 shows while recruiting
NCT04788524 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (79% lower).
The record links to 1 condition, with Major Depressive Disorder appearing as the primary indexed condition, and to 1 intervention - of which Computer Task Manipulation is the first listed.
NCT04788524 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04788524 about?
NCT04788524 is a clinical study titled "Neural Correlates of Stress and Perceived Control in Adolescent Depression". Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnet...
What is the current status of trial NCT04788524?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2021-04-23. Estimated completion is 2026-04-30.
What conditions does trial NCT04788524 study?
This clinical trial studies the following conditions: Major Depressive Disorder.
What interventions are being tested in trial NCT04788524?
The interventions under investigation include: Computer Task Manipulation (BEHAVIORAL).
Who is sponsoring clinical trial NCT04788524?
This trial is sponsored by Mclean Hospital, which has 140 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04788524 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04788524's enrollment target sits among peer trials
80 143rd of 282 higher than 134 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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