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NCT04713722 · ClinicalTrials.gov registry record
Early Life Stress and Depression: Molecular and Functional Imaging
A clinical trial of Depression and Trauma, Psychological, sponsored by Mclean Hospital.
- Recruiting
- Registry status
- 160
- Enrollment target
- 1
- Study location
NCT04713722: Recruiting study of Depression and Trauma, Psychological, sponsored by Mclean Hospital.
NCT04713722 is a study of Depression and Trauma, Psychological that is actively recruiting participants, run by Mclean Hospital. The registered enrollment target is 160 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04713722, a study of Depression and Trauma, Psychological, is actively recruiting participants, sponsored by Mclean Hospital.
- RECRUITING
- Registry status
- 160 participants
- Enrollment target
- 1
- Study location
Study Summary
Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experiences (they are resilient). In spite of this, little is known about the neurobiological mechanisms related to childhood adversity, especially oxidative stress abnormalities in the brain. To fill this gap, this study combines functional, structural, and molecular imaging approaches to examine the role of oxidative stress abnormalities related to childhood adversity.
Primary Outcome
Redox ratio and glutamate metabolites in the prefrontal cortex
Conditions Studied
Study Locations (1)
Massachusetts
- McLean Hospital - Belmont
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2021-02-01 |
| Est. Completion | 2026-06-30 |
What NCT04713722 shows while recruiting
NCT04713722 is an observational study that tracks outcomes without assigning an intervention. The registered 160 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (80% lower).
The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 0 interventions.
NCT04713722 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04713722 about?
NCT04713722 is a clinical study titled "Early Life Stress and Depression: Molecular and Functional Imaging". Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experience...
What is the current status of trial NCT04713722?
This trial is currently recruiting. The enrollment target is 160 participants. The study started on 2021-02-01. Estimated completion is 2026-06-30.
What conditions does trial NCT04713722 study?
This clinical trial studies the following conditions: Depression, Trauma, Psychological.
Who is sponsoring clinical trial NCT04713722?
This trial is sponsored by Mclean Hospital, which has 140 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04713722 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04713722's enrollment target sits among peer trials
160 237th of 679 higher than 439 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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