Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Psychosis clinical trials
Every US clinical trial registered for Psychosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
36 US clinical trials · 17 currently recruiting
The research picture
Psychosis has 36 registered US clinical trials, 17 of them open to new participants right now — about 47% of the total.
- 17
- recruiting participants now
- 47%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Mclean Hospital
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Enhanced Coordinated Specialty Care for Early Psychosis
Mclean Hospital
NCT06071858
Determining the Role of Social Reward Learning in Social Anhedonia
University of Alabama at Birmingham
NCT05617898
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
Massachusetts General Hospital
NCT04940663
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
University of North Carolina, Chapel Hill
NCT05282277
Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia
Vanderbilt University Medical Center
NCT07196462
Cerebellar Modulation of Cognition in Psychosis
Mclean Hospital
NCT06107764
Neural Basis of Social Cognition Deficits
Loma Linda University
NCT05185128
A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults
New York University
NCT06508450
Enhancing Rehabilitation for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT06586164
Targeting Emotion Dysregulation to Reduce Suicide in People With Psychosis
University of Maryland, Baltimore
NCT05440214
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk
Northwell Health
NCT05131035
Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
Mclean Hospital
NCT06221852
Acute Psychiatric Care at Home for Lower-risk Patients With Acute Psychiatric Illness Who Require Inpatient Care
Brigham and Women's Hospital
NCT07364825
The Effectiveness of Individualized Imagery Scripts on Sleep, Psychosis, and Suicidality Among Inpatients With Psychosis
The University of Texas Health Science Center, Houston
NCT06194344
Toward a Computationally-Informed, Personalized Treatment for Hallucinations
Yale University
NCT04366518
Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis
Nicholas Breitborde
NCT04368039
Multiomic Diagnostics in Youth With Psychosis
Rady Pediatric Genomics & Systems Medicine Institute
NCT05457140
AMP SCZ® Observational Study: PREDICT-DPACC
Brigham and Women's Hospital
NCT05905003
EPI-MINN: Targeting Cognition and Motivation
University of Minnesota
NCT05112432
Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial
University of California, Los Angeles
NCT04338152
EPI-MINN: Targeting Cognition and Motivation - National
University of Minnesota
NCT05877716
Trajectories of Treatment Response as Window Into the Heterogeneity of Psychosis: a Longitudinal Multimodal Imaging Study
University of Alabama at Birmingham
NCT03442101
CBT-I to Improve Functional Outcomes in Veterans With Psychosis
VA Office of Research and Development
NCT04646200
Youth Nominated Support Team
University of California, Irvine
NCT05558332
Probing the Cannabinoid System in Individuals With a Family History of Psychosis
Yale University
NCT02102113
Psychosis TMS Study
Massachusetts General Hospital
NCT05857137
CSC OnDemand: An Innovative Online Learning Platform for Implementing Coordinated Specialty Care
Center for Social Innovation, Massachusetts
NCT03465371
Participatory Messaging in the UCLA Psychiatry Partial Hospitalization and Intensive Outpatient Programs
University of California, Los Angeles
NCT02708940
Improving Adherence to Cognitive Rehabilitation
VA Office of Research and Development
NCT02481713
Social Cognitive Training for Psychosis: Treatment Development
Yale University
NCT01579422
mHealth for Psychosis Help-seeking
University of Washington
NCT05905601
DMHI for At-Risk College Students
University of Washington
NCT06608498
Levetiracetam in Early Psychosis
NYU Langone Health
NCT03129360
Families With Substance Use and Psychosis: A Pilot Study
Mclean Hospital
NCT04284813
CSC OnDemand: An Innovative Online Learning Platform for Implementing Coordinated Specialty Care
Center for Social Innovation, Massachusetts
NCT02933567
A Usability Study of a Smoking Cessation Decision Aid in People With a Recent First Episode of Psychosis
Northwell Health
NCT01399112
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Psychosis Trial Landscape
ClinicalTrials.gov lists 36 US studies indexed under Psychosis, and 17 of those are currently open to recruitment — roughly 47% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Psychosis shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Psychosis is led by Mclean Hospital with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 36 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Psychosis?
PlainTrial tracks 36 US clinical trials for Psychosis, of which 17 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Psychosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.