Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Psychosis: early-phase trial registry
17 of 36 indexed Psychosis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #419 of 28,707 conditions by registered trial count.
36 US clinical trials · 17 currently recruiting · #419 of 28,707 conditions by registered trial count
Psychosis: 36 US clinical trials tracked, 17 recruiting.
Psychosis is the subject of 36 registered US clinical trials on ClinicalTrials.gov, 17 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Mclean Hospital, running 4 of these trials.
Enrollment posture brief
Registry condition psychosis
OPEN 17 | RECR 47% | LATE 1 | EARLY 4 | RANK #419 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Crohn Disease (47% recruiting · 72 trials)
Psychosis lists 17 open slots (47% of 36 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Psychosis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Psychosis is recruiting above its size-band peers.
17 of 36 indexed trials (47.2%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Psychosis trials is spread across many organizations.
Mclean Hospital accounts for 4 of 36 trials (11.1%). 21 distinct sponsors appear on at least one study for this condition label.
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Most Psychosis trials plan to enrol fewer than 100 people.
Median target enrolment is 80 among the 36 trials that report a genuine target (sentinel values excluded). 22 of those (61.1%) plan for fewer than 100 participants.
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Psychosis research is mostly interventional.
34 interventional and 2 observational studies make up this index (94.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
36 total, page 1 of 1
Enhanced Coordinated Specialty Care for Early Psychosis
Mclean Hospital
NCT06071858
Determining the Role of Social Reward Learning in Social Anhedonia
University of Alabama at Birmingham
NCT05617898
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
Massachusetts General Hospital
NCT04940663
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
University of North Carolina, Chapel Hill
NCT05282277
Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia
Vanderbilt University Medical Center
NCT07196462
Cerebellar Modulation of Cognition in Psychosis
Mclean Hospital
NCT06107764
Neural Basis of Social Cognition Deficits
Loma Linda University
NCT05185128
A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults
New York University
NCT06508450
Enhancing Rehabilitation for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT06586164
Targeting Emotion Dysregulation to Reduce Suicide in People With Psychosis
University of Maryland, Baltimore
NCT05440214
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk
Northwell Health
NCT05131035
Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
Mclean Hospital
NCT06221852
Acute Psychiatric Care at Home for Lower-risk Patients With Acute Psychiatric Illness Who Require Inpatient Care
Brigham and Women's Hospital
NCT07364825
The Effectiveness of Individualized Imagery Scripts on Sleep, Psychosis, and Suicidality Among Inpatients With Psychosis
The University of Texas Health Science Center, Houston
NCT06194344
Toward a Computationally-Informed, Personalized Treatment for Hallucinations
Yale University
NCT04366518
Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis
Nicholas Breitborde
NCT04368039
Multiomic Diagnostics in Youth With Psychosis
Rady Pediatric Genomics & Systems Medicine Institute
NCT05457140
AMP SCZ® Observational Study: PREDICT-DPACC
Brigham and Women's Hospital
NCT05905003
EPI-MINN: Targeting Cognition and Motivation
University of Minnesota
NCT05112432
Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial
University of California, Los Angeles
NCT04338152
EPI-MINN: Targeting Cognition and Motivation - National
University of Minnesota
NCT05877716
Trajectories of Treatment Response as Window Into the Heterogeneity of Psychosis: a Longitudinal Multimodal Imaging Study
University of Alabama at Birmingham
NCT03442101
CBT-I to Improve Functional Outcomes in Veterans With Psychosis
VA Office of Research and Development
NCT04646200
Youth Nominated Support Team
University of California, Irvine
NCT05558332
Probing the Cannabinoid System in Individuals With a Family History of Psychosis
Yale University
NCT02102113
Psychosis TMS Study
Massachusetts General Hospital
NCT05857137
CSC OnDemand: An Innovative Online Learning Platform for Implementing Coordinated Specialty Care
Center for Social Innovation, Massachusetts
NCT03465371
Participatory Messaging in the UCLA Psychiatry Partial Hospitalization and Intensive Outpatient Programs
University of California, Los Angeles
NCT02708940
Improving Adherence to Cognitive Rehabilitation
VA Office of Research and Development
NCT02481713
Social Cognitive Training for Psychosis: Treatment Development
Yale University
NCT01579422
mHealth for Psychosis Help-seeking
University of Washington
NCT05905601
DMHI for At-Risk College Students
University of Washington
NCT06608498
Levetiracetam in Early Psychosis
NYU Langone Health
NCT03129360
Families With Substance Use and Psychosis: A Pilot Study
Mclean Hospital
NCT04284813
CSC OnDemand: An Innovative Online Learning Platform for Implementing Coordinated Specialty Care
Center for Social Innovation, Massachusetts
NCT02933567
A Usability Study of a Smoking Cessation Decision Aid in People With a Recent First Episode of Psychosis
Northwell Health
NCT01399112
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Psychosis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Psychosis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Psychosis page
36 registered trials, 17 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 17 Psychosis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Mclean Hospital sponsors the most Psychosis trials on record, review their full trial history before evaluating a specific study. See Mclean Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Psychosis condition card totals 36 registered trials; most-linked intervention Early Psychosis Coordinated Specialty Care; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.