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Bipolar Disorder: later-stage trial registry
37 of 163 indexed Bipolar Disorder trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #66 of 28,707 conditions by registered trial count.
163 US clinical trials · 37 currently recruiting · #66 of 28,707 conditions by registered trial count
Bipolar Disorder: 163 US clinical trials tracked, 37 recruiting.
Bipolar Disorder is the subject of 163 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 11 of these trials.
Enrollment posture brief
Registry condition bipolar-disorder
OPEN 37 | RECR 23% | LATE 45 | EARLY 15 | RANK #66 | SPON 11
Volume-matched condition peers
Nearest open-share peer: Hypogonadism (23% recruiting · 22 trials)
Bipolar Disorder lists 37 open slots (23% of 163 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Bipolar Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Bipolar Disorder is recruiting below its size-band peers.
37 of 163 indexed trials (22.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Bipolar Disorder trials is spread across many organizations.
Massachusetts General Hospital accounts for 11 of 163 trials (6.7%). 73 distinct sponsors appear on at least one study for this condition label.
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Typical Bipolar Disorder enrolment sits around 75 participants.
Median target enrolment is 75 among the 163 trials that report a genuine target (sentinel values excluded). 92 of those (56.4%) plan for fewer than 100 participants.
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Bipolar Disorder research is mostly interventional.
133 interventional and 30 observational studies make up this index (81.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
163 total, page 1 of 4
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
National Institute of Mental Health (NIMH)
NCT00024635
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
National Institute of Mental Health (NIMH)
NCT05669703
University of Iowa Interventional Psychiatry Service Patient Registry
Mark Niciu
NCT04480918
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
Massachusetts General Hospital
NCT04296604
Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
Intra-Cellular Therapies
NCT06229210
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
Bristol-Myers Squibb
NCT07140913
A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)
Eli Lilly and Company
NCT07286175
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
Xenon Pharmaceuticals
NCT07172516
Enhanced Coordinated Specialty Care for Early Psychosis
Mclean Hospital
NCT06071858
Taking Action for College Students
Temple University
NCT06700902
mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders
VA Office of Research and Development
NCT06204705
Cerebellar Stimulation and Cognitive Control
Krystal Parker, PhD
NCT03217110
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Mayo Clinic
NCT06897670
CBT-CP for Veterans With SMI
VA Office of Research and Development
NCT06758414
Healthy Lifestyles in Bipolar Disorder: Bay Area Study
University of California, Berkeley
NCT06555406
Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder
Massachusetts General Hospital
NCT06274567
Early Intervention for Youth at High Risk for Bipolar Disorder
University of Pittsburgh
NCT04815239
Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders
University of Pittsburgh
NCT07043803
Examining Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD)
University of Pittsburgh
NCT06081426
Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder
University Hospitals Cleveland Medical Center
NCT03829787
Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder
Stony Brook University
NCT06373016
Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study
University of Texas at Austin
NCT05838274
Personalized Mobile Cognitive Behavioral Therapy Application
Weill Medical College of Cornell University
NCT05699525
Visual Perception in Schizophrenia
University of Rochester
NCT06911931
Enhancing Rehabilitation for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT06586164
Children's Bipolar Network Treatment Trial I
University of California, Los Angeles
NCT05427123
A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder
Massachusetts General Hospital
NCT06609902
Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders
Medical University of South Carolina
NCT05064319
Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)
Joao L. DeQuevedo
NCT04080778
Getting Out of the House: Using Behavioral Activation to Increase Community Participation
Temple University
NCT06336616
Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder
Leslie Swanson
NCT06226025
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
Neurocrine Biosciences
NCT07105111
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Yale University
NCT05786066
BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study
Massachusetts General Hospital
NCT02481245
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
Michigan State University
NCT06529029
Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder
Mclean Hospital
NCT05457465
Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT05491538
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
University of Texas Southwestern Medical Center
NCT06002204
Evaluation of the Genetics of Bipolar Disorder
National Institute of Mental Health (NIMH)
NCT00001174
Effectiveness RCT of Customized Adherence Enhancement
Case Western Reserve University
NCT04622150
Using mHealth to Improve Adherence and Reduce Blood Pressure in Individuals With Hypertension and Mood Disorders
Case Western Reserve University
NCT04675593
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Brigham and Women's Hospital
NCT03336918
Imaging mGluR5 and Synaptic Density in Psychiatric Disorders
Yale University
NCT03898297
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression
Mclean Hospital
NCT03484494
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
National Institute of Mental Health (NIMH)
NCT05172271
Person-Centered Versus Measurement-Based Care in Mental Health
University of Pittsburgh
NCT02507349
Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study
National Institute of Mental Health (NIMH)
NCT00006177
A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania
Otsuka Pharmaceutical Development & Commercialization
NCT00261443
Quetiapine Fumarate Bipolar Maintenance Monotherapy
AstraZeneca
NCT00314184
A Phase IV Study of the Safety and Efficacy of Aripiprazole in Combination With Lamotrigine in the Long-Term Maintenance Treatment of Patients With Bipolar I Disorder With A Recent Manic or Mixed Episode
Otsuka Pharmaceutical Development & Commercialization
NCT00277212
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 12 |
| Phase 3 | 23 |
| Phase 4 | 22 |
Top Sponsors
Named interventions
Most-linked intervention names on Bipolar Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Bipolar Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Bipolar Disorder page
163 registered trials, 37 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 37 Bipolar Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Bipolar Disorder trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Bipolar Disorder condition card totals 163 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.