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Bipolar Disorder clinical trials
37 of 163 indexed Bipolar Disorder trials are currently recruiting.
163 US clinical trials · 37 currently recruiting
Bipolar Disorder is the subject of 163 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 11 of these trials.
The research picture
Bipolar Disorder has 163 registered US clinical trials, 37 of them open to new participants right now, about 23% of the total.
- 37
- recruiting participants now
- 23%
- of trials open to enrollment
- 45
- in Phase 3–4 (later-stage)
- 11
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
163 total, page 1 of 4
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
National Institute of Mental Health (NIMH)
NCT00024635
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
National Institute of Mental Health (NIMH)
NCT05669703
University of Iowa Interventional Psychiatry Service Patient Registry
Mark Niciu
NCT04480918
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
Massachusetts General Hospital
NCT04296604
Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
Intra-Cellular Therapies
NCT06229210
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
Bristol-Myers Squibb
NCT07140913
A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)
Eli Lilly and Company
NCT07286175
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
Xenon Pharmaceuticals
NCT07172516
Enhanced Coordinated Specialty Care for Early Psychosis
Mclean Hospital
NCT06071858
Taking Action for College Students
Temple University
NCT06700902
mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders
VA Office of Research and Development
NCT06204705
Cerebellar Stimulation and Cognitive Control
Krystal Parker, PhD
NCT03217110
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Mayo Clinic
NCT06897670
CBT-CP for Veterans With SMI
VA Office of Research and Development
NCT06758414
Healthy Lifestyles in Bipolar Disorder: Bay Area Study
University of California, Berkeley
NCT06555406
Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder
Massachusetts General Hospital
NCT06274567
Early Intervention for Youth at High Risk for Bipolar Disorder
University of Pittsburgh
NCT04815239
Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders
University of Pittsburgh
NCT07043803
Examining Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD)
University of Pittsburgh
NCT06081426
Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder
University Hospitals Cleveland Medical Center
NCT03829787
Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder
Stony Brook University
NCT06373016
Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study
University of Texas at Austin
NCT05838274
Personalized Mobile Cognitive Behavioral Therapy Application
Weill Medical College of Cornell University
NCT05699525
Visual Perception in Schizophrenia
University of Rochester
NCT06911931
Enhancing Rehabilitation for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT06586164
Children's Bipolar Network Treatment Trial I
University of California, Los Angeles
NCT05427123
A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder
Massachusetts General Hospital
NCT06609902
Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders
Medical University of South Carolina
NCT05064319
Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)
Joao L. DeQuevedo
NCT04080778
Getting Out of the House: Using Behavioral Activation to Increase Community Participation
Temple University
NCT06336616
Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder
Leslie Swanson
NCT06226025
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
Neurocrine Biosciences
NCT07105111
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Yale University
NCT05786066
BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study
Massachusetts General Hospital
NCT02481245
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
Michigan State University
NCT06529029
Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder
Mclean Hospital
NCT05457465
Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT05491538
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
University of Texas Southwestern Medical Center
NCT06002204
Evaluation of the Genetics of Bipolar Disorder
National Institute of Mental Health (NIMH)
NCT00001174
Effectiveness RCT of Customized Adherence Enhancement
Case Western Reserve University
NCT04622150
Using mHealth to Improve Adherence and Reduce Blood Pressure in Individuals With Hypertension and Mood Disorders
Case Western Reserve University
NCT04675593
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Brigham and Women's Hospital
NCT03336918
Imaging mGluR5 and Synaptic Density in Psychiatric Disorders
Yale University
NCT03898297
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression
Mclean Hospital
NCT03484494
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
National Institute of Mental Health (NIMH)
NCT05172271
Person-Centered Versus Measurement-Based Care in Mental Health
University of Pittsburgh
NCT02507349
Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study
National Institute of Mental Health (NIMH)
NCT00006177
A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania
Otsuka Pharmaceutical Development & Commercialization
NCT00261443
Quetiapine Fumarate Bipolar Maintenance Monotherapy
AstraZeneca
NCT00314184
A Phase IV Study of the Safety and Efficacy of Aripiprazole in Combination With Lamotrigine in the Long-Term Maintenance Treatment of Patients With Bipolar I Disorder With A Recent Manic or Mixed Episode
Otsuka Pharmaceutical Development & Commercialization
NCT00277212
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 12 |
| Phase 3 | 23 |
| Phase 4 | 22 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Bipolar Disorder Trial Landscape
163 indexed Bipolar Disorder studies · 37 recruiting (23%).
Phase mix: 45 late (III/IV) vs 15 early (I/II).
Top sponsor: Massachusetts General Hospital (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Bipolar Disorder?
PlainTrial tracks 163 US clinical trials for Bipolar Disorder, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Bipolar Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.