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ClinicalTrials.gov 58 recruiting now official registry

Sarcoma clinical trials

58 of 129 indexed Sarcoma trials are currently recruiting.

129 US clinical trials · 58 currently recruiting

Sarcoma is the subject of 129 registered US clinical trials on ClinicalTrials.gov, 58 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 26 of these trials.

The research picture

Sarcoma has 129 registered US clinical trials, 58 of them open to new participants right now, about 45% of the total.

58
recruiting participants now
45%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
26
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 137Phase 243Phase 38Phase 42

Active & Recent Trials

129 total, page 2 of 3

RECRUITING Phase 2 24 participants

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

University of California, Irvine

NCT07447050

RECRUITING NA 20 participants

A Checklist (Advanced Care Planning) for The Assessment of Mobility Needs in Patients With Sarcoma

Fred Hutchinson Cancer Center

NCT05835154

RECRUITING Phase 2 20 participants

Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

University of Colorado, Denver

NCT07125183

RECRUITING NA 20 participants

GRID Therapy for Extremity Soft Tissue Sarcoma

UNC Lineberger Comprehensive Cancer Center

NCT06073067

RECRUITING Phase 4 20 participants

Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study

Duke University

NCT03144206

RECRUITING Phase 2 16 participants

Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcoma

Gabriel Tino

NCT06528769

RECRUITING 10 participants

Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women

Washington University School of Medicine

NCT06904365

RECRUITING Phase 1 8 participants

Palbociclib and Pembrolizumab in Sarcoma

John Rieth

NCT06113809

ACTIVE NOT RECRUITING 57,816 participants

Enrollment on the Childhood Cancer Research Network (CCRN) of the Children's Oncology Group

Children's Oncology Group

NCT01117168

ACTIVE NOT RECRUITING 6,000 participants

Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract

Memorial Sloan Kettering Cancer Center

NCT00582647

ACTIVE NOT RECRUITING 1,275 participants

Genomic Structural Variation in Cancer Susceptibility

Memorial Sloan Kettering Cancer Center

NCT00996710

ACTIVE NOT RECRUITING 1,150 participants

A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors

TScan Therapeutics

NCT05812027

ACTIVE NOT RECRUITING Phase 2 350 participants

9-ING-41 in Patients with Advanced Cancers

Actuate Therapeutics

NCT03678883

ACTIVE NOT RECRUITING Phase 3 220 participants

Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy

Memorial Sloan Kettering Cancer Center

NCT01223248

ACTIVE NOT RECRUITING Phase 4 100 participants

Registry of Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet®

CivaTech Oncology

NCT04033081

ACTIVE NOT RECRUITING NA 92 participants

Oncology Dashboard for the Improvement of Operational Efficiency and Patients Outcomes in Patients With Sarcoma

M.D. Anderson Cancer Center

NCT05216029

ACTIVE NOT RECRUITING Phase 2 88 participants

A Study of NKTR-214 in Combination With Nivolumab in Patients With Metastatic and/or Locally Advanced Sarcoma

Memorial Sloan Kettering Cancer Center

NCT03282344

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

HiFiBiO Therapeutics

NCT05238883

ACTIVE NOT RECRUITING Phase 1 70 participants

Aerosolized Aldesleukin in Treating Patients With Lung Metastases

M.D. Anderson Cancer Center

NCT01590069

ACTIVE NOT RECRUITING Phase 2 65 participants

Irinotecan and Carboplatin as Upfront Window Therapy in Treating Patients With Newly Diagnosed Intermediate-Risk or High-Risk Rhabdomyosarcoma

Memorial Sloan Kettering Cancer Center

NCT00077285

ACTIVE NOT RECRUITING Phase 2 60 participants

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

M.D. Anderson Cancer Center

NCT02713269

ACTIVE NOT RECRUITING Phase 2 41 participants

A Study of Talimogene Laherparepvec (T-VEC) in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma

Memorial Sloan Kettering Cancer Center

NCT03069378

ACTIVE NOT RECRUITING Phase 1 36 participants

Her2 Chimeric Antigen Receptor Expressing T Cells in Advanced Sarcoma

Baylor College of Medicine

NCT00902044

ACTIVE NOT RECRUITING Phase 2 33 participants

Study of Abemaciclib in Dedifferentiated Liposarcoma

Memorial Sloan Kettering Cancer Center

NCT02846987

ACTIVE NOT RECRUITING Phase 2 31 participants

SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma

Sarcoma Oncology Research Center

NCT03778996

ACTIVE NOT RECRUITING Phase 2 30 participants

A Study of Epacadostat, an IDO1 Inhibitor, in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma

Memorial Sloan Kettering Cancer Center

NCT03414229

ACTIVE NOT RECRUITING Early Phase 1 30 participants

Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)

University of Iowa

NCT04634227

ACTIVE NOT RECRUITING Phase 1 21 participants

Nivolumab or Nivolumab and Azacitidine in Patients With Recurrent, Resectable Osteosarcoma

H. Lee Moffitt Cancer Center and Research Institute

NCT03628209

ACTIVE NOT RECRUITING Early Phase 1 18 participants

68Ga-FAPi-46 PET/CT Scan in Imaging Patients With Sarcoma

Jonsson Comprehensive Cancer Center

NCT04457258

ACTIVE NOT RECRUITING Phase 2 16 participants

A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma

Memorial Sloan Kettering Cancer Center

NCT05886634

ACTIVE NOT RECRUITING Early Phase 1 15 participants

Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell Tumor

Memorial Sloan Kettering Cancer Center

NCT01189643

ACTIVE NOT RECRUITING Phase 1 14 participants

Bevacizumab/Doxorubicin/Radiation for Sarcoma

Massachusetts General Hospital

NCT01746238

ACTIVE NOT RECRUITING Early Phase 1 14 participants

Immunotherapy + Radiation in Resectable Soft Tissue Sarcoma

University of Rochester

NCT03463408

ACTIVE NOT RECRUITING NA 11 participants

Proton Pencil Beam Scanning GRID for Treatment of Bulky Tumors

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05121545

ACTIVE NOT RECRUITING NA 7 participants

PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study

Memorial Sloan Kettering Cancer Center

NCT02307630

COMPLETED Phase 3 587 participants

Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor

Children's Oncology Group

NCT00006734

COMPLETED Phase 3 481 participants

Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

Children's Oncology Group

NCT00354835

COMPLETED Phase 3 370 participants

Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis

Alliance for Clinical Trials in Oncology

NCT00091351

COMPLETED Phase 3 250 participants

Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer

University of South Florida

NCT00369564

COMPLETED Phase 3 216 participants

Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Cancer of the Uterus

Gynecologic Oncology Group

NCT00002546

COMPLETED Phase 3 198 participants

A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families

Tufts Medical Center

NCT00782145

COMPLETED NA 163 participants

Incisional Negative Pressure Wound Therapy for Preoperatively Irradiated Lower Extremity Soft Tissue Sarcoma Wounds

Medical University of South Carolina

NCT02638298

COMPLETED Phase 2 136 participants

Trivalent Ganglioside Vaccine With Immunological Adjuvant or Immunological Adjuvant Alone in Metastatic Sarcoma Patients Who Are Rendered Disease Free

MabVax Therapeutics

NCT01141491

COMPLETED Phase 1 120 participants

A Pilot Study for the Treatment of Patients With Metastatic and High Risk Sarcomas and Primitive Neuroectodermal Tumors

National Cancer Institute (NCI)

NCT00001209

COMPLETED 101 participants

iCAT for Recurrent/Refractory/HR Solid Tumors

Dana-Farber Cancer Institute

NCT01853345

COMPLETED Phase 2 85 participants

Troglitazone in Treating Patients With Liposarcoma

Dana-Farber Cancer Institute

NCT00003058

COMPLETED Phase 2 82 participants

Gemcitabine, Docetaxel, and Filgrastim in Treating Patients With Recurrent or Persistent Leiomyosarcoma or Soft Tissue Sarcoma

Memorial Sloan Kettering Cancer Center

NCT00004066

COMPLETED Phase 2 75 participants

S0423 Pemetrexed Disodium in Treating Patients With Recurrent and Unresectable or Metastatic Chondrosarcoma

SWOG Cancer Research Network

NCT00107419

COMPLETED Phase 2 70 participants

Reproducibility of 18F Uptake by Solid Tumors Using PET Imaging Following Intravenous Administration of (18F) Injection

GE Healthcare

NCT00918281

COMPLETED NA 61 participants

Dynamic Contrast Enhanced MRI(DCE-MRI)of Bone Tumors

Memorial Sloan Kettering Cancer Center

NCT00598741

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Phase Distribution

PhaseTrial count
Phase 1 37
Phase 2 43
Phase 3 8
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Sarcoma Trial Landscape

129 indexed Sarcoma studies · 58 recruiting (45%).

Phase mix: 10 late (III/IV) vs 80 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (26 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Sarcoma?

PlainTrial tracks 129 US clinical trials for Sarcoma, of which 58 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Sarcoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.