UNC Lineberger Comprehensive Cancer Center

374 total trials 298 currently recruiting 52 completed

Trial Pipeline

RECRUITING Phase 2

PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

NCT07069595

RECRUITING Phase 1

Hyaluronic Acid-based Gel Spacers in Gynecologic Malignancies

NCT07292818

RECRUITING Phase 2

Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia

NCT07278557

RECRUITING NA

Nutrition Awareness Among Women With Non-Metastatic Breast Cancer

NCT07389967

RECRUITING NA

Feasibility of Symptom Management for Patients With Metastatic Breast Cancer to Increase Exercise

NCT07313306

RECRUITING NA

Medically Tailored Meals for Kids

NCT06814795

RECRUITING Phase 2

Translation of Acoustic Angiography: Contrast Enhanced Super Resolution (CESR) Imaging

NCT07225114

RECRUITING NA

Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors

NCT06848491

RECRUITING NA

Consumer Perceptions of Alcoholic Beverages

NCT07226271

RECRUITING NA

Perceived Effectiveness of Vaping Prevention Ads Among Adolescents and Young Adults

NCT07116837

RECRUITING NA

Dissemination of BREASTChoice AIM1-B

NCT07396766

RECRUITING NA

Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer

NCT07025785

RECRUITING NA

Expanding the Support of Family Caregivers of Diverse Patients With Cancer and Diabetes

NCT07061652

RECRUITING NA

PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

NCT06896162

RECRUITING NA

mPATH-Cloud for Colorectal Cancer Screening

NCT06441487

RECRUITING NA

Combating Cancer-Related Fatigue: A Personalized Supportive Care Program

NCT06860880

RECRUITING Phase 1

XL092 and Cemiplimab in BRAF WT Thyroid Cancer

NCT06902376

RECRUITING NA

Implementation of an Oral Chemotherapy Adherence Intervention

NCT06989489

RECRUITING Phase 2

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

NCT06727773

RECRUITING NA

Designing Visual Tools to Enhance Cancer Surgeon Decision-making

NCT06965192

RECRUITING NA

Digital Art Therapy for Young Cancer Survivors

NCT06789666

RECRUITING Phase 2

Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)

NCT06902311

RECRUITING

VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker: Evaluation of Anisotropy in Cancer Patients

NCT06878547

RECRUITING NA

Effectiveness of Central Oncology Navigation and the Use of an ORN

NCT06618274

RECRUITING Phase 1

Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel

NCT06483555

RECRUITING NA

Rehabilitation Outcomes Study

NCT06674889

RECRUITING NA

Promoting Resilience in Women With Breast Cancer (PRISM -MBC)

NCT06855654

RECRUITING

A Novel Approach Utilizing Organ Specific Age Proteomics

NCT06789653

RECRUITING NA

Multimedia Aid for Genetic Testing in Gynecologic Oncology

NCT07084168

RECRUITING NA

BREAST Choice Decision Tool R21 - AIM2

NCT06817226

RECRUITING Phase 1

Autologous CAR-T Cells Targeting B7H3 in Ovarian Cancer iC9-CAR.B7-H3 T Cells

NCT06305299

RECRUITING Phase 1

Autologous CAR-T Cells Targeting B7-H3 in PDAC

NCT06158139

RECRUITING Phase 1

Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells

NCT06347068

RECRUITING NA

DISCOVERY: Evaluating a Decision Support Tool for Adults Seen in Hematology/Oncology Clinics

NCT06296368

RECRUITING

Blood and Urine HPVDNA as Minimally Invasive Biomarkers for Cervical Cancer Detection and Surveillance Following Treatment

NCT04743674

RECRUITING Phase 1

ATLCAR.CD30.CCR4 for CD30+ HL ATLCAR.CD30.CCR4 Cells

NCT06090864

RECRUITING

UNC Metastatic Cancer Radiation Therapy Registry

NCT06306924

RECRUITING Phase 1

Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC

NCT06096038

RECRUITING NA

Promoting CT Engagement for Pancreatic Cancer With App

NCT06252545

RECRUITING Phase 1

The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study

NCT04700527

RECRUITING NA

Integrating Biological, Clinical, and Behavioral Factors to Improve Breast Cancer Outcomes - Carolina Breast Cancer Study

NCT07214610

RECRUITING NA

Improving Thoracic Surgical Care Using Electronic Patient-Reported Outcomes (ePROS)

NCT06075316

RECRUITING NA

GRID Therapy for Extremity Soft Tissue Sarcoma

NCT06073067

RECRUITING NA

The Care Tracker Study: Using Patient-Reported Data to Address Racial Disparity in Cancer Treatment

NCT06096623

RECRUITING Phase 1

ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer

NCT05542407

RECRUITING

Brain Slice Explants to Predict Drug Response in Brain Tumors

NCT05978557

RECRUITING Early Phase 1

Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer

NCT05620342

RECRUITING

Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies

NCT05743426

RECRUITING Early Phase 1

Comparison of CE-DBT and MRI in Patients With Known Breast Lesions

NCT05754749

RECRUITING

Young Adult Infusion Space Experience Satisfaction Survey

NCT05720546

RECRUITING NA

Evaluation of Child Care Staff Weight Management Program

NCT05656807

RECRUITING NA

Adaptation of a Values Assessment Tool

NCT07068477

RECRUITING Phase 2

Study of Trilaciclib and Lurbinectidin

NCT05578326

RECRUITING Phase 1

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

NCT05366179

RECRUITING

Evaluation of the Acceptability, Appropriateness, and Feasibility/Usability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians

NCT05440929

RECRUITING Phase 2

Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy

NCT05472792

RECRUITING Phase 2

Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma

NCT05145400

RECRUITING

UNC Childhood, Adolescent, and Young Adult Cancer Cohort

NCT05096923

RECRUITING

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

NCT04564989

RECRUITING Phase 1

Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

NCT04223765

RECRUITING

Circulating Tumor DNA (ctDNA) in Locally Advanced Head and Neck Squamous Cell Carcinoma

NCT04099290

RECRUITING

MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets

NCT04073966

RECRUITING Phase 2

CD30 CAR for Relapsed/Refractory CD30+ T Cell Lymphoma

NCT04083495

RECRUITING Phase 2

Tumor Subtypes in Subjects on FOLFIRINOX With Non-Metastatic Pancreatic Cancer

NCT03977233

RECRUITING Phase 1

Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma

NCT03721068

RECRUITING NA

Harnessing Analysis RNA Expression and Molecular Subtype to Optimize Novel TherapY MBCA

NCT03769415

RECRUITING

Registry for Adults With Plasma Cell Disorders (PCD's)

NCT03717844

RECRUITING Phase 1

Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors

NCT03454035

RECRUITING

UNC Pleural Fluid Registry

NCT05620329

RECRUITING

Registry of Older Patients With Cancer

NCT01137825

RECRUITING

Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

NCT01137643

RECRUITING

Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior

NCT01000883

ACTIVE NOT RECRUITING NA

Physical Activity Centers Empowerment

NCT06411756

ACTIVE NOT RECRUITING Phase 2

Isa-Pom-Dex in Elderly/Frail Subjects With RRMM

NCT05911321

ACTIVE NOT RECRUITING NA

Measuring Changes in Body Composition and Physical Function in Patients With Childhood Cancers

NCT05823740

ACTIVE NOT RECRUITING NA

Impact of Financial Incentives

NCT05744960

ACTIVE NOT RECRUITING NA

Impact of Standing Orders Optimization

NCT05742386

ACTIVE NOT RECRUITING Phase 2

Polatuzumab Vedotin With R-GDP in Relapsed/Refractory Diffuse Large B-cell Lymphoma

NCT05498220

ACTIVE NOT RECRUITING

Long-Term Follow-Up in Women With Early Breast Cancer Three Years of More Post Primary Treatment

NCT05926024

ACTIVE NOT RECRUITING Phase 2

Pembrolizumab Plus Olaparib in LA-HNSCC

NCT05366166

ACTIVE NOT RECRUITING

Patient Related Outcomes for Gynecologic Radiation Oncology

NCT04753086

ACTIVE NOT RECRUITING NA

PRO-VISION: Patient Reported Outcomes-Based Monitoring of VEGF-Inhibitor Side Effects in ONcology

NCT05592665

ACTIVE NOT RECRUITING

Immuno-Oncology Database and Bioregistry

NCT04656873

ACTIVE NOT RECRUITING Phase 1

Phase I Study of Autologous CAR T-Cells Targeting the B7-H3 Antigen in Recurrent Epithelial Ovarian

NCT04670068

ACTIVE NOT RECRUITING Phase 2

A Pilot Study of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas

NCT04548648

ACTIVE NOT RECRUITING Phase 2

Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer

NCT03978624

ACTIVE NOT RECRUITING Phase 2

Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN

NCT03529422

ACTIVE NOT RECRUITING Early Phase 1

Study of PD-1 Inhibitors After CD30.CAR T Cell Therapy in Relapsed/Refractory Hodgkin Lymphoma

NCT04134325

ACTIVE NOT RECRUITING Phase 1

Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma

NCT03696784

ACTIVE NOT RECRUITING Phase 1

Study of ATLCAR.CD138 Cells for Relapsed/Refractory Multiple Myeloma

NCT03672318

ACTIVE NOT RECRUITING Phase 1

Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL

NCT03602157

ACTIVE NOT RECRUITING Phase 2

BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma

NCT03264131

ACTIVE NOT RECRUITING Phase 2

Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

NCT03174275

ACTIVE NOT RECRUITING Phase 1

Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL

NCT02690545

ACTIVE NOT RECRUITING Phase 1

Administration of T Lymphocytes for Prevention of Relapse of Lymphomas

NCT02663297

ACTIVE NOT RECRUITING Phase 1

Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALL

NCT03016377

COMPLETED NA

Little Cigar and Cigarillo Warnings for Youth

NCT06413797

COMPLETED NA

Mobile Weight Loss Intervention for Adolescent and Young Adult Cancer Survivors

NCT06171945

COMPLETED NA

Impact of E-Cigarette Prevention Messages on Adolescents

NCT05985538

COMPLETED NA

Physical Activity and Healthy Eating Among Young Adult Cancer Survivors

NCT05887401

Phase Distribution

PhaseTrial count
Phase 1 62
Phase 2 81

What the Pipeline for UNC Lineberger Comprehensive Cancer Center Shows

According to the ClinicalTrials.gov registry, UNC Lineberger Comprehensive Cancer Center is linked to 374 US clinical trials across every stage of research activity. Of those, 298 studies are currently recruiting — about 80% of the sponsor's indexed portfolio — and 52 are already marked complete, representing roughly 14% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for UNC Lineberger Comprehensive Cancer Center reports 0 late-stage studies (Phase 3 and Phase 4 combined) and 143 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for UNC Lineberger Comprehensive Cancer Center is Breast Cancer with 29 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial