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ClinicalTrials.gov 15 recruiting now official registry

Type 2 Diabetes Mellitus clinical trials

15 of 123 indexed Type 2 Diabetes Mellitus trials are currently recruiting.

123 US clinical trials · 15 currently recruiting

Type 2 Diabetes Mellitus is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 51 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 11 of these trials.

The research picture

Type 2 Diabetes Mellitus has 123 registered US clinical trials, 15 of them open to new participants right now, about 12% of the total.

15
recruiting participants now
12%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
11
top sponsor: AstraZeneca
Phase 128Phase 223Phase 316Phase 410

Active & Recent Trials

123 total, page 1 of 3

RECRUITING 50,000 participants

An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions

Bayer

NCT06278207

RECRUITING Phase 3 1,600 participants

A Clinical Study to Evaluate the Effects of RO7795068 in Participants With Obesity or Overweight and Type 2 Diabetes

Hoffmann-La Roche

NCT07351058

RECRUITING Phase 3 685 participants

Proact: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

Prokidney

NCT05099770

RECRUITING NA 400 participants

GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes

Medtronic Diabetes

NCT07228117

RECRUITING NA 264 participants

Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes

Endogenex

NCT06267391

RECRUITING Phase 2 240 participants

A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes

Hoffmann-La Roche

NCT07112872

RECRUITING NA 216 participants

The GRoceries Aimed at Increasing Nutrition Study

University of Pennsylvania

NCT07167004

RECRUITING NA 100 participants

Preventing Type 2 Diabetes in Black Emergent Adult

University of North Carolina, Chapel Hill

NCT06848244

RECRUITING 100 participants

Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)

Petter Bjornstad

NCT05008276

RECRUITING Phase 2 100 participants

Regulation of Endogenous Glucose Production by Central KATP Channels

Meredith Hawkins

NCT03540758

RECRUITING Phase 1 70 participants

A Study to Evaluate the Effect of Maridebart Cafraglutide on Insulin Sensitivity and β-cell Function in Participants With Type 2 Diabetes Mellitus

Amgen

NCT07160257

RECRUITING 60 participants

The PRECISION II Study: Evaluating the Accuracy of the LabPatch Glucose Sensing System

Joslin Diabetes Center

NCT05754281

RECRUITING Phase 2 60 participants

Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

Yale University

NCT05067621

RECRUITING Phase 1 22 participants

A Study to Evaluate Pharmacokinetics of LY3209590 in Pediatric Participants With Type 2 Diabetes Mellitus

Eli Lilly and Company

NCT06362265

RECRUITING 20 participants

A Study of Glycemic Control in Left Ventricular Assist

Mayo Clinic

NCT05933161

ACTIVE NOT RECRUITING 150,000 participants

An Observational Study to Learn More About How Safe Finerenone is and How Well it Works in People With Chronic Kidney Disease and Type 2 Diabetes in Routine Medical Care in the United States

Bayer

NCT06608212

ACTIVE NOT RECRUITING 4,500 participants

A Study Called FINE-REAL to Learn More About the Use of the Drug Finerenone in a Routine Medical Care Setting

Bayer

NCT05348733

ACTIVE NOT RECRUITING 395 participants

Elucidation of Breast Milk Composition and Structure Over the First Year of Lactation: UC Davis Lactation Study

University of California, Davis

NCT01817127

ACTIVE NOT RECRUITING Phase 4 92 participants

Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism

VA Office of Research and Development

NCT03887936

ACTIVE NOT RECRUITING NA 70 participants

Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes

Baltimore VA Medical Center

NCT01176578

ACTIVE NOT RECRUITING NA 69 participants

The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes

University of Pittsburgh

NCT01047735

ACTIVE NOT RECRUITING NA 40 participants

Impact of Metabolic Health on Sperm Epigenetic Marks in Humans

Joslin Diabetes Center

NCT03860558

ACTIVE NOT RECRUITING NA 40 participants

An Evaluation of the Omnipod® M System in Adults With Type 2 Diabetes

Insulet Corporation

NCT07276776

ACTIVE NOT RECRUITING Early Phase 1 28 participants

GLP-1 and Hypoglycemia

University of Maryland, Baltimore

NCT01858896

ACTIVE NOT RECRUITING NA 15 participants

Is the Degree of Perceived Effort During Resistance Exercise Important for Improvements in Blood Glucose

University of New Mexi

NCT06208189

COMPLETED 96,759 participants

Impact of Medicaid Health Home on Patients With Diabetes in New York City

Icahn School of Medicine at Mount Sinai

NCT02713321

COMPLETED 6,000 participants

Improving Diabetes in Primary Care (IMPACT)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00108927

COMPLETED Phase 3 2,734 participants

A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor

Novo Nordisk A/S

NCT06065540

COMPLETED Phase 3 2,639 participants

Efficacy and Safety of Alogliptin Plus Metformin Compared to Glipizide Plus Metformin in Patients With Type 2 Diabetes Mellitus

Takeda

NCT00856284

COMPLETED Phase 3 1,912 participants

Study of Rivoglitazone in Type 2 Diabetes Mellitus

Daiichi Sankyo

NCT00484198

COMPLETED Phase 2 1,664 participants

A Study to Learn How Well the Treatment Combination of Finerenone and Empagliflozin Works and How Safe it is Compared to Each Treatment Alone in Adult Participants With Long-term Kidney Disease (Chronic Kidney Disease) and Type 2 Diabetes

Bayer

NCT05254002

COMPLETED 1,297 participants

An Observational Study Evaluating SYMLIN® (Pramlintide Acetate) Injection Use in Insulin Using Patients With Type 2 and Type 1 Diabetes

AstraZeneca

NCT00229658

COMPLETED 1,123 participants

Detection of Ischemia in Asymptomatic Diabetics

Yale University

NCT00769275

COMPLETED Phase 4 949 participants

Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina

Gilead Sciences

NCT01425359

COMPLETED Phase 3 878 participants

Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes on Non-insulin Antidiabetic Therapy

Sanofi

NCT01676220

COMPLETED Phase 3 650 participants

A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin

AstraZeneca

NCT02551874

COMPLETED Phase 2 593 participants

Phase 2b Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Group Study to Assess the PD Response and Safety of Three Dose Levels of (PB1023) Injection Following 20 Weeks of Weekly SC Dosing in Adults With T2DM

PhaseBio Pharmaceuticals

NCT01658501

COMPLETED Phase 3 571 participants

Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents

Lexicon Pharmaceuticals

NCT03285594

COMPLETED NA 536 participants

Mi Puente: My Bridge to Better Cardiometabolic Health and Well-Being

Scripps Whittier Diabetes Institute

NCT02723019

COMPLETED Phase 3 497 participants

Safety and Efficacy of Dapagliflozin as Monotherapy in Subjects With Type 2 Diabetes

AstraZeneca

NCT00736879

COMPLETED Phase 3 406 participants

Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Diet and Exercise

Hanmi Pharmaceutical Company Limited

NCT03353350

COMPLETED Phase 3 357 participants

Welchol as Monotherapy for Type 2 Diabetes Mellitus

Daiichi Sankyo

NCT00789737

COMPLETED NA 317 participants

Evaluation of Updated Continuous Glucose Monitoring (CGM) Form Factor in Adults, Adolescents and Pediatrics

Medtronic Diabetes

NCT04436822

COMPLETED Phase 2 299 participants

Safety and Efficacy of LX4211 With Metformin in Type 2 Diabetes Patients With Inadequate Glycemic Control on Metformin

Lexicon Pharmaceuticals

NCT01376557

COMPLETED NA 265 participants

Medical Care, Education, Social Support, And Goal-setting to Empower Self-management for Diabetes

University of Chicago

NCT03487692

COMPLETED Phase 2 259 participants

Study of AC-201 in Patients With Type 2 Diabetes Mellitus

TWi Biotechnology

NCT01276106

COMPLETED Phase 3 254 participants

A Study to Evaluate the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly in Subjects With Type 2 Diabetes Mellitus (DURATION-5)

AstraZeneca

NCT00877890

COMPLETED Phase 2 246 participants

To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes Therapies

Novartis

NCT01068860

COMPLETED Phase 4 236 participants

Colesevelam for Children With Type 2 Diabetes

Daiichi Sankyo

NCT01258075

COMPLETED Phase 2 229 participants

An Open-label, Multi-center, International, Three-year, Safety and Tolerability 'Follow on' Trial

Mannkind Corporation

NCT00754624

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Phase Distribution

PhaseTrial count
Phase 1 28
Phase 2 23
Phase 3 16
Phase 4 10

Top Sponsors

AstraZeneca 11 trials
Bayer 4 trials
Daiichi Sankyo 4 trials
Sanofi 4 trials
Gilead Sciences 3 trials
Pfizer 3 trials
Yale University 3 trials
GlaxoSmithKline 3 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Type 2 Diabetes Mellitus Trial Landscape

123 indexed Type 2 Diabetes Mellitus studies · 15 recruiting (12%).

Phase mix: 26 late (III/IV) vs 51 early (I/II).

Top sponsor: AstraZeneca (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Type 2 Diabetes Mellitus?

PlainTrial tracks 123 US clinical trials for Type 2 Diabetes Mellitus, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Type 2 Diabetes Mellitus?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.