Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Type 2 Diabetes Mellitus
Open-data reference.
123 US clinical trials · 15 currently recruiting
Active & Recent Trials
An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
Bayer
NCT06278207
A Clinical Study to Evaluate the Effects of RO7795068 in Participants With Obesity or Overweight and Type 2 Diabetes
Hoffmann-La Roche
NCT07351058
Proact: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease
Prokidney
NCT05099770
GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes
Medtronic Diabetes
NCT07228117
Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes
Endogenex
NCT06267391
A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes
Hoffmann-La Roche
NCT07112872
The GRoceries Aimed at Increasing Nutrition Study
University of Pennsylvania
NCT07167004
Preventing Type 2 Diabetes in Black Emergent Adult
University of North Carolina, Chapel Hill
NCT06848244
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Petter Bjornstad
NCT05008276
Regulation of Endogenous Glucose Production by Central KATP Channels
Meredith Hawkins
NCT03540758
A Study to Evaluate the Effect of Maridebart Cafraglutide on Insulin Sensitivity and β-cell Function in Participants With Type 2 Diabetes Mellitus
Amgen
NCT07160257
The PRECISION II Study: Evaluating the Accuracy of the LabPatch Glucose Sensing System
Joslin Diabetes Center
NCT05754281
Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease
Yale University
NCT05067621
A Study to Evaluate Pharmacokinetics of LY3209590 in Pediatric Participants With Type 2 Diabetes Mellitus
Eli Lilly and Company
NCT06362265
A Study of Glycemic Control in Left Ventricular Assist
Mayo Clinic
NCT05933161
An Observational Study to Learn More About How Safe Finerenone is and How Well it Works in People With Chronic Kidney Disease and Type 2 Diabetes in Routine Medical Care in the United States
Bayer
NCT06608212
A Study Called FINE-REAL to Learn More About the Use of the Drug Finerenone in a Routine Medical Care Setting
Bayer
NCT05348733
Elucidation of Breast Milk Composition and Structure Over the First Year of Lactation: UC Davis Lactation Study
University of California, Davis
NCT01817127
Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism
VA Office of Research and Development
NCT03887936
Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes
Baltimore VA Medical Center
NCT01176578
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
University of Pittsburgh
NCT01047735
Impact of Metabolic Health on Sperm Epigenetic Marks in Humans
Joslin Diabetes Center
NCT03860558
An Evaluation of the Omnipod® M System in Adults With Type 2 Diabetes
Insulet Corporation
NCT07276776
GLP-1 and Hypoglycemia
University of Maryland, Baltimore
NCT01858896
Is the Degree of Perceived Effort During Resistance Exercise Important for Improvements in Blood Glucose
University of New Mexi
NCT06208189
Impact of Medicaid Health Home on Patients With Diabetes in New York City
Icahn School of Medicine at Mount Sinai
NCT02713321
Improving Diabetes in Primary Care (IMPACT)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00108927
A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor
Novo Nordisk A/S
NCT06065540
Efficacy and Safety of Alogliptin Plus Metformin Compared to Glipizide Plus Metformin in Patients With Type 2 Diabetes Mellitus
Takeda
NCT00856284
Study of Rivoglitazone in Type 2 Diabetes Mellitus
Daiichi Sankyo
NCT00484198
A Study to Learn How Well the Treatment Combination of Finerenone and Empagliflozin Works and How Safe it is Compared to Each Treatment Alone in Adult Participants With Long-term Kidney Disease (Chronic Kidney Disease) and Type 2 Diabetes
Bayer
NCT05254002
An Observational Study Evaluating SYMLIN® (Pramlintide Acetate) Injection Use in Insulin Using Patients With Type 2 and Type 1 Diabetes
AstraZeneca
NCT00229658
Detection of Ischemia in Asymptomatic Diabetics
Yale University
NCT00769275
Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina
Gilead Sciences
NCT01425359
Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes on Non-insulin Antidiabetic Therapy
Sanofi
NCT01676220
A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin
AstraZeneca
NCT02551874
Phase 2b Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Group Study to Assess the PD Response and Safety of Three Dose Levels of (PB1023) Injection Following 20 Weeks of Weekly SC Dosing in Adults With T2DM
PhaseBio Pharmaceuticals
NCT01658501
Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents
Lexicon Pharmaceuticals
NCT03285594
Mi Puente: My Bridge to Better Cardiometabolic Health and Well-Being
Scripps Whittier Diabetes Institute
NCT02723019
Safety and Efficacy of Dapagliflozin as Monotherapy in Subjects With Type 2 Diabetes
AstraZeneca
NCT00736879
Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Diet and Exercise
Hanmi Pharmaceutical Company Limited
NCT03353350
Welchol as Monotherapy for Type 2 Diabetes Mellitus
Daiichi Sankyo
NCT00789737
Evaluation of Updated Continuous Glucose Monitoring (CGM) Form Factor in Adults, Adolescents and Pediatrics
Medtronic Diabetes
NCT04436822
Safety and Efficacy of LX4211 With Metformin in Type 2 Diabetes Patients With Inadequate Glycemic Control on Metformin
Lexicon Pharmaceuticals
NCT01376557
Medical Care, Education, Social Support, And Goal-setting to Empower Self-management for Diabetes
University of Chicago
NCT03487692
Study of AC-201 in Patients With Type 2 Diabetes Mellitus
TWi Biotechnology
NCT01276106
A Study to Evaluate the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly in Subjects With Type 2 Diabetes Mellitus (DURATION-5)
AstraZeneca
NCT00877890
To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes Therapies
Novartis
NCT01068860
Colesevelam for Children With Type 2 Diabetes
Daiichi Sankyo
NCT01258075
An Open-label, Multi-center, International, Three-year, Safety and Tolerability 'Follow on' Trial
Mannkind Corporation
NCT00754624
REAL HEALTH-Diabetes: Reach Ahead for Lifestyle and Health-Diabetes
Massachusetts General Hospital
NCT02320253
A 12-week Study To Evaluate PF-06291874 Once a Day in Adults With T2DM Inadequately Controlled On Metformin
Pfizer
NCT02554877
A Study to Evaluate Safety and Efficacy of TTP054 for 12 Weeks in Subjects With Type 2 Diabetes
vTv Therapeutics
NCT01665352
The Efficacy and Treatment Adherence With an Integrated Program on HbA1c Scores in Patients With Type 2 Diabetes
KRJG Services
NCT01626053
Integrating Depression Services Into DM Management
University of Pennsylvania
NCT01098253
University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial)
University of Florida
NCT00994682
Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)
Merck Sharp & Dohme
NCT04029480
Ginkgo Biloba Extract and the Insulin Resistance Syndrome
National Center for Complementary and Integrative Health (NCCIH)
NCT00032474
A Study of LGD-6972 in Patients With Type 2 Diabetes Mellitus
Ligand Pharmaceuticals
NCT02851849
Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00212290
Study of KD026 in Combination With Metformin in Subjects With Type 2 Diabetes Mellitus
Response Pharmaceuticals
NCT02434744
Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes
Massachusetts General Hospital
NCT03818581
Physical Activity and Participation
VA Office of Research and Development
NCT02268916
Long Term Free Living Study With Modified Foods and Type 2 Diabetics
Johns Hopkins Bloomberg School of Public Health
NCT00198913
4-Week, Multiple-dose, Dose-escalating Study In Patients With Type 2 Diabetes
Pfizer
NCT03538743
Exercise Training and Glucose Metabolism in Aging
US Department of Veterans Affairs
NCT00701051
Safety and Efficacy Study of PN2034 in Type 2 Diabetes Patients on Concomitant Rosiglitazone and Metformin (or Avandamet)
Wellstat Therapeutics
NCT00110851
Surgery or Lifestyle With Intensive Medical Management in the Treatment of Type 2 Diabetes
Joslin Diabetes Center
NCT01073020
A First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM12460A
Hanmi Pharmaceutical Company Limited
NCT01724814
A Phase 1 Single/Multiple Dose Study Of PF-06293620 To Assess Safety, Tolerability And Pharmacokinetics In Subjects With Type 2 Diabetes Mellitus
Pfizer
NCT02211261
A Study of Renal Autologous Cell Therapy (REACT) in Type 2 Diabetics With Chronic Kidney Disease
Prokidney
NCT02836574
Dance Dance Revolution (DDR) in Type 2 Diabetes
Charles Drew University of Medicine and Science
NCT00851019
Adding Liraglutide to High Dose Insulin: Breaking the Cycle
Ildiko Lingvay
NCT01505673
A Trial to Assess Steviol Glycosides on Acute Appetite Hormone Release
Midwest Center for Metabolic and Cardiovascular Research
NCT05287906
A Bioequivalence Study Testing Two Formulations of Sotagliflozin in Healthy Male and Female Subjects Under Fasted Conditions
Sanofi
NCT03776227
A Study to Examine the Pharmacokinetics, Tolerability, Safety and Efficacy of Exenatide Once Weekly Suspension
AstraZeneca
NCT00894322
Signaling Mechanisms and Vascular Function in Patients With Diabetes Mellitus
Brigham and Women's Hospital
NCT00762671
Financial Incentives Telephone Education and Skills Trial in African Americans With Diabetes (FITEST)
State University of New York at Buffalo
NCT02722499
Effect of Diabetes Mellitus on Cholesterol Metabolism
Medical College of Wisconsin
NCT00879710
Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome
Baylor Research Institute
NCT02251431
Grocery Prescription Program for Medicaid Adults With Hypertension or Type 2 Diabetes
Alison Gustafson
NCT06033664
TAK-648 Multiple-Rising Dose Study in Healthy Japanese Participants and Non-Japanese Participants With Type 2 Diabetes Mellitus
Takeda
NCT02430870
Yo Puedo! Diabetes Self-Management Education + mHealth in Mexico City
Yale University
NCT03159299
Diabetes Prevention and Control in the Workplace: A Pilot Study
State University of New York - Upstate Medical University
NCT00739336
Ketones, Muscle Metabolism, and SGLT2 Inhibitors - Protocol 1
The University of Texas Health Science Center at San Antonio
NCT03560323
Vascular Effects of Rosiglitazone Versus Glyburide in Type 2 Diabetic Patients
St. Paul Heart Clinic
NCT00123643
A Study to Compare the Safety and Drug Levels in Blood When Using Various Forms of GSK189075 Given to Healthy Subjects
GlaxoSmithKline
NCT00559884
Effects on Colesevelam HC1 (WelChol®) on Insulin Sensitivity in Subjects With Type 2 Diabetes Mellitus
Daiichi Sankyo
NCT00361153
Study to Assess Safety and Pharmacokinetics of Double-Blind S-707106 Alone and in Combination With Open-Label Metformin in Patients With Type 2 Diabetes Mellitus
Shionogi
NCT01154348
Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes
Pacira Pharmaceuticals
NCT02762370
Continuous Glucose Monitoring (CGM) in Subjects With Type 2 Diabetes
Rocky Mountain Diabetes and Osteoporosis Center
NCT01341067
Effect of Exenatide on 24-Hour Blood Glucose Profile Compared With Placebo in Patients With Type 2 Diabetes
AstraZeneca
NCT00241423
A Phase I Study to Assess the Pharmacodynamics of Oral AR-C165395XX in Subjects With Type 2 Diabetes Mellitus (T2DM)
AstraZeneca
NCT02367066
Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects
AstraZeneca
NCT00904176
A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function
GlaxoSmithKline
NCT00501462
Antioxidant Effects of Pomegranate Juice Versus Placebo in Adults With Type 2 Diabetes Mellitus
University of Colorado, Denver
NCT00668954
Does Pioglitazone Increase the Production of 15-EPI-Lipoxin A4?
Baylor College of Medicine
NCT01040819
Single Cohort, 2-Period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine 500 mg
Gilead Sciences
NCT01546558
Determinants of Diabetes Remission After Gastric Bypass Surgery
Blandine Laferrere
NCT02287285
A Clinical Study to Investigate the Effect of SAR425899 on Energy Expenditure in Obese Subjects
Sanofi
NCT03376802
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 28 |
| Phase 2 | 23 |
| Phase 3 | 16 |
| Phase 4 | 10 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Type 2 Diabetes Mellitus Trial Landscape
ClinicalTrials.gov lists 123 US studies indexed under Type 2 Diabetes Mellitus, and 15 of those are currently open to recruitment — roughly 12% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Type 2 Diabetes Mellitus shows 26 late-stage studies (Phase 3 and Phase 4 combined) alongside 51 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Type 2 Diabetes Mellitus is led by AstraZeneca with 11 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Type 2 Diabetes Mellitus?
PlainTrial tracks 123 US clinical trials for Type 2 Diabetes Mellitus, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 2 Diabetes Mellitus?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.