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A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors
NCT05812027 · View on ClinicalTrials.gov ↗
Study Summary
TScan Therapeutics is developing cellular therapies across multiple solid tumors in which autologous T cells are engineered to express a T cell receptor that recognizes tumor-associated antigens presented on specific Human Leukocyte Antigen (HLA) molecules. The purpose of this screening study is to collect samples to conduct HLA genotyping, HLA Loss of Heterozygosity (LOH) assessment, and expression of Tumor-associated Antigens (TAA) testing. These results will be used to determine if participants meet the eligibility criteria for these parameters and could potentially be enrolled in a TScan clinical study.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Tumor and HLA Profiling
Study Locations (20)
Florida
- Memorial Healthcare System — Hollywood
- University of Miami, Sylvester Comprehensive Cancer Center — Miami
- Orlando Health — Orlando
- University of South Florida — Tampa
Ohio
- Oncology Hematology Care — Cincinnati
- The Cleveland Clinic — Cleveland
Pennsylvania
- Allegheny Hospitals Network — Pittsburgh
- University of Pittsburgh Medical Center — Pittsburgh
Arizona
- HonorHealth Research and Innovation Institute — Scottsdale
California
- University of California San Diego — San Diego
Connecticut
- Yale Cancer Center — New Haven
Illinois
- University of Chicago — Chicago
Kentucky
- Norton Cancer Institute — Louisville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,150 participants |
| Start Date | 2023-06-26 |
| Est. Completion | 2027-01-14 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05812027
The ClinicalTrials.gov registry entry for NCT05812027 describes a study currently listed as active not recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,150 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is TScan Therapeutics, which has 32 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 7 conditions, with Head and Neck Cancer appearing as the primary indexed condition, and to 1 intervention — of which Tumor and HLA Profiling is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05812027 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Florida, Ohio, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05812027 about?
NCT05812027 is a clinical study titled "A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors". TScan Therapeutics is developing cellular therapies across multiple solid tumors in which autologous T cells are engineered to express a T cell receptor that recognizes tumor-associated antigens presented on specific Human Leukocyte Antigen (HLA) molecules. The purpose of this screening study is to ...
What is the current status of trial NCT05812027?
This trial is currently active not recruiting. The enrollment target is 1,150 participants. The study started on 2023-06-26. Estimated completion is 2027-01-14.
What conditions does trial NCT05812027 study?
This clinical trial studies the following conditions: Head and Neck Cancer, Cervical Cancer, Non Small Cell Lung Cancer, Sarcoma, Uveal Melanoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05812027?
The interventions under investigation include: Tumor and HLA Profiling (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05812027?
This trial is sponsored by TScan Therapeutics, which has 32 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05812027 being conducted?
This trial has 20 study locations across Arizona, California, Connecticut, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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