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NCT03778996 · ClinicalTrials.gov registry record · Phase 2
SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma
A Phase 2 study of Sarcoma and Sarcoma, Ewing, sponsored by Sarcoma Oncology Research Center.
- Active
- Registry status
- Phase 2
- Development phase
- 31
- Enrollment target
- 1
- Study location
NCT03778996: Active Phase 2 study of Sarcoma and Sarcoma, Ewing, sponsored by Sarcoma Oncology Research Center.
NCT03778996 is a Phase 2 study of Sarcoma and Sarcoma, Ewing that is active but no longer recruiting, run by Sarcoma Oncology Research Center. The registered enrollment target is 31 participants, below the 921-participant average among 122 other Sarcoma trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03778996, a Phase 2 study of Sarcoma and Sarcoma, Ewing, is active but no longer recruiting, sponsored by Sarcoma Oncology Research Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 31 participants
- Enrollment target
- 1
- Study location
Study Summary
The primary objective is to evaluate the efficacy of SM-88, a combination metabolic cancer treatment, in two study cohorts: * Clinically advanced Ewing's Sarcoma patients who have not progressed at the conclusion of systemic treatment * Clinically advanced sarcoma patients in the salvage treatment setting Up to 24 efficacy evaluable patients (up to 12 per cohort) will be enrolled. Study patients will receive oral SM-88, with scheduled safety and efficacy evaluations.
Primary Outcome
Complete response (CR) + partial response (PR) as evaluated using RECIST 1.1
Conditions Studied
Interventions
- DRUG Combination metyrosine-derivative, low-dose methoxsalen, phenytoin and sirolimus (MPS)
Study Locations (1)
California
- Sarcoma Oncology Research Center - Santa Monica
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2020-01-03 |
| Est. Completion | 2028-03-31 |
| Phase | Phase 2 |
What the registry record for NCT03778996 still lists
NCT03778996 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 31 participants, a relatively small participant target, below the 921-participant average among 122 other Sarcoma trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Sarcoma appearing as the primary indexed condition, and to 1 intervention - of which Combination metyrosine-derivative, low-dose methoxsalen, phenytoin and sirolimus (MPS) is the first listed.
NCT03778996 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT03778996 about?
NCT03778996 is a clinical study titled "SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma". The primary objective is to evaluate the efficacy of SM-88, a combination metabolic cancer treatment, in two study cohorts: * Clinically advanced Ewing's Sarcoma patients who have not progressed at the conclusion of systemic treatment * Clinically advanced sarcoma patients in the salvage treatment ...
What is the current status of trial NCT03778996?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 31 participants. The study started on 2020-01-03. Estimated completion is 2028-03-31.
What conditions does trial NCT03778996 study?
This clinical trial studies the following conditions: Sarcoma, Sarcoma, Ewing.
What interventions are being tested in trial NCT03778996?
The interventions under investigation include: Combination metyrosine-derivative, low-dose methoxsalen, phenytoin and sirolimus (MPS) (DRUG).
Who is sponsoring clinical trial NCT03778996?
This trial is sponsored by Sarcoma Oncology Research Center, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03778996 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sarcoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03778996's enrollment target sits among peer trials
31 85th of 122 higher than 38 of 122 other Sarcoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sarcoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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