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ClinicalTrials.gov 26 recruiting now official registry

Psoriasis clinical trials

Every US clinical trial registered for Psoriasis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

127 US clinical trials · 26 currently recruiting

The research picture

Psoriasis has 127 registered US clinical trials, 26 of them open to new participants right now — about 20% of the total.

26
recruiting participants now
20%
of trials open to enrollment
50
in Phase 3–4 (later-stage)
8
top sponsor: Bristol-Myers Squibb

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 2,500 participants

IMPACT - AndHealth Autoimmune Research Registry

AndHealth

NCT05883371

RECRUITING 1,500 participants

A Real-world Observational Study to Compare Effectiveness of Deucravacitinib Vs Apremilast in Adults With Plaque Psoriasis

Bristol-Myers Squibb

NCT05744466

RECRUITING 1,000 participants

Psorcast Mobile Study

Sage Bionetworks

NCT05621369

RECRUITING NA 520 participants

Prevention of Cardiovascular Disease and Mortality in Patients With Psoriasis or Psoriatic Arthritis

University of Pennsylvania

NCT05908240

RECRUITING Phase 1 300 participants

Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer

National Cancer Institute (NCI)

NCT03816345

RECRUITING 300 participants

Metabolic Profiling of Immune Responses in Immune-mediated Diseases

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04864886

RECRUITING 240 participants

Skin Microbial Ecology in Atopic Dermatitis

University of Rochester

NCT04170244

RECRUITING 200 participants

Stelara and Tremfya Pregnancy Exposure Registry OTIS Autoimmune Diseases in Pregnancy Project

University of California, San Diego

NCT02103361

RECRUITING Phase 4 200 participants

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

Eli Lilly and Company

NCT06857942

RECRUITING Phase 4 176 participants

Multi-Center PAMPA Study

NYU Langone Health

NCT05004727

RECRUITING Phase 1 132 participants

Evaluate the Safety and Pharmacokinetics/Pharmacodynamics of HS-20118

Jiangsu Hansoh Pharmaceutical Co.

NCT06846710

RECRUITING 125 participants

Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors

M.D. Anderson Cancer Center

NCT04751396

RECRUITING NA 100 participants

A Study to Evaluate the Impact of a Magnolia Officinalis Dietary Supplement on Immune Biomarkers in Subjects With Psoriasis

Sirt3

NCT07471048

RECRUITING Phase 1 90 participants

Study of SFA002 in Patients with Mild to Moderate Psoriasis Plaques

SFA Therapeutics

NCT05642182

RECRUITING Phase 4 56 participants

Development of Predictive Psoriasis Response Endotypes Using Single Cell Transcriptomics

University Hospitals Cleveland Medical Center

NCT05270733

RECRUITING Phase 4 45 participants

A Safety and Pharmacokinetics Study of IDP-122 Lotion in Pediatric Participants With Plaque Psoriasis

Bausch Health Americas

NCT03987763

RECRUITING Phase 4 45 participants

A Safety and Pharmacokinetics Study of IDP-118 Lotion in Pediatric Participants With Plaque Psoriasis

Bausch Health Americas

NCT03988439

RECRUITING NA 36 participants

Mediterranean Diet vs no Dietary Intervention for Improving Signs and Symptoms of Psoriasis in Patients Treated With Anti-IL-17 or Anti-IL-23 Inhibitors

University Hospitals Cleveland Medical Center

NCT06399432

RECRUITING NA 30 participants

An Open-Label, Pilot Study to Evaluate the Efficacy of Narrowband Ultraviolet-B Phototherapy Three Times Weekly for Twelve Weeks in Moderate-to-Severe Psoriasis Patients

Psoriasis Treatment Center of Central New Jersey

NCT03392337

RECRUITING Phase 4 30 participants

Enstilar in Combination With Enbrel or Humira for Plaque Psoriasis

Psoriasis Treatment Center of Central New Jersey

NCT03827876

RECRUITING Phase 4 25 participants

Duobrii in Combination With Biologics

Psoriasis Treatment Center of Central New Jersey

NCT04119102

RECRUITING Phase 4 25 participants

ILUMYA in Combination With HALOG Ointment 0.1% for Plaque Psoriasis.

Psoriasis Treatment Center of Central New Jersey

NCT04347473

RECRUITING Phase 4 25 participants

Taltz in Combination With Enstilar for Psoriasis

Psoriasis Treatment Center of Central New Jersey

NCT04372277

RECRUITING Phase 1 16 participants

Maximal Usage Pharmacokinetics and Safety Study of ARQ-154 Foam 0.3% in Pediatric Participants With Scalp and Body Psoriasis

Arcutis Biotherapeutics

NCT07340216

RECRUITING 13 participants

Regulation of Inflammatory Genes in Psoriasis

University of Alabama at Birmingham

NCT03125655

RECRUITING NA 5 participants

Use of Total-Body PET to Quantify Systemic and Cutaneous Inflammation in Psoriasis Patients Before and After Intervention With a Nutritionally Balanced Diet

University of California, Davis

NCT06574178

ACTIVE NOT RECRUITING 15,842 participants

Psoriasis Longitudinal Assessment and Registry

Janssen Scientific Affairs

NCT00508547

ACTIVE NOT RECRUITING 15,000 participants

A Longitudinal Observational Study of Patients Undergoing Therapy for IMISC

Target PharmaSolutions

NCT03661866

ACTIVE NOT RECRUITING Phase 3 1,680 participants

Long-term Safety and Efficacy of ESK-001 in Moderate to Severe Plaque Psoriasis

Alumis

NCT06846541

ACTIVE NOT RECRUITING Phase 3 1,466 participants

Long-Term Study That Measures the Safety and Efficacy of Deucravacitinib (BMS-986165) in Participants With Psoriasis

Bristol-Myers Squibb

NCT04036435

ACTIVE NOT RECRUITING 925 participants

OTIS Cimzia Pregnancy Registry

University of California, San Diego

NCT01797224

ACTIVE NOT RECRUITING 833 participants

A Study on the Safety of Deucravacitinib Exposure in Pregnant Women and Their Offspring

Bristol-Myers Squibb

NCT06710470

ACTIVE NOT RECRUITING Phase 3 250 participants

Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight

Eli Lilly and Company

NCT06588283

ACTIVE NOT RECRUITING 233 participants

Apremilast Pregnancy Exposure Registry

University of California, San Diego

NCT02775500

ACTIVE NOT RECRUITING Phase 3 132 participants

Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 6 and 17 Years With Moderate to Severe Plaque Psoriasis Treated With Subcutaneous (SC) Injection of Risankizumab Who Have Completed Participation in Study M19-977

AbbVie

NCT04862286

ACTIVE NOT RECRUITING Phase 3 120 participants

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Guselkumab for the Treatment of Chronic Plaque Psoriasis in Pediatric Participants

Janssen Research & Development

NCT03451851

ACTIVE NOT RECRUITING NA 60 participants

Role of Intermittent Fasting in Psoriasis and Psoriatic Arthritis

Ohio State University

NCT05590247

ACTIVE NOT RECRUITING NA 40 participants

Deucravacitinib Adherence Study

Wake Forest University Health Sciences

NCT05570955

ACTIVE NOT RECRUITING NA 20 participants

Use of Transcutaneous Electrical Nerve Stimulation for Reducing Biologic Injection Site Pain(TENS Study)

Wake Forest University Health Sciences

NCT04058652

ACTIVE NOT RECRUITING Phase 4 20 participants

Risankizumab Long-term Remission Study

Jaehwan Kim

NCT04630652

ACTIVE NOT RECRUITING Phase 4 2 participants

An Open-label, Single-dose Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Brodalumab in Pediatric Subjects

Bausch Health Americas

NCT03240809

COMPLETED 1,846 participants

A Study to Evaluate Psoriasis Outcomes and Safety Events in Patients With Chronic Moderate to Severe Plaque Psoriasis (RESPONSE)

Genentech

NCT00096928

COMPLETED Phase 3 1,296 participants

A Phase 3 Study in Participants With Moderate to Severe Psoriasis

Eli Lilly and Company

NCT01474512

COMPLETED Phase 3 1,224 participants

A Phase 3 Study in Participants With Moderate to Severe Psoriasis (UNCOVER-2)

Eli Lilly and Company

NCT01597245

COMPLETED NA 943 participants

Asthma and Atopic Dermatitis Validation of PROMIS Pediatric Instruments

Northwestern University

NCT03051347

COMPLETED Phase 3 901 participants

A One-Year Study To Evaluate The Effects And Safety Of CP-690,550 In Patients With Moderate To Severe Chronic Plaque Psoriasis

Pfizer

NCT01276639

COMPLETED Phase 3 658 participants

A Study to Assess the Safety and Effectiveness of Tacrolimus Cream in the Treatment of Psoriasis

Astellas Pharma

NCT00293891

COMPLETED 600 participants

Assessment of Digital Imaging as a Tool for Diagnosing Psoriasis, Hand Rashes and Unusual Moles

National Cancer Institute (NCI)

NCT00005781

COMPLETED Phase 3 542 participants

Evaluate the Efficacy and Safety of M518101 in Subjects With Plaque Psoriasis

Maruho North America

NCT01878461

COMPLETED Phase 3 494 participants

A Study to Investigate Interchangeability of ABP 654 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis

Amgen

NCT04761627

COMPLETED Phase 3 480 participants

Long Term Study to Evaluate Safety and Efficacy of M518101 in Subjects With Plaque Psoriasis

Maruho North America

NCT01908595

COMPLETED Phase 2 426 participants

A Study to Assess the Efficacy and Safety of PPC-06 (Tepilamide Fumarate)

Dr. Reddy's Laboratories Limited

NCT03421197

COMPLETED 409 participants

Impact of the Severity of Pediatric Psoriasis on Childhood Body Mass Index

Northwestern University

NCT00879944

COMPLETED Phase 3 394 participants

A Comparison of DFD01 Spray Versus Comp01 Lotion, Vehicle Spray and Vehicle Lotion in Subjects With Moderate Psoriasis

Primus Pharmaceuticals

NCT01947491

COMPLETED Phase 4 352 participants

Study of Subcutaneous Risankizumab Injection Compared to Oral Apremilast Tablets to Assess Change in Disease Activity And Adverse Events in Adult Participants With Moderate Plaque Psoriasis Who Are Candidates for Systemic Therapy

AbbVie

NCT04908475

COMPLETED Phase 3 327 participants

Risankizumab Versus Secukinumab for Participants With Moderate to Severe Plaque Psoriasis

AbbVie

NCT03478787

COMPLETED Phase 3 303 participants

A Study of the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Moderate to Severe Plaque Psoriasis of the Scalp

Amgen

NCT03123471

COMPLETED NA 300 participants

Collaborative Connected Health (CCH) for PCORI

University of Southern California

NCT02358135

COMPLETED Phase 2 271 participants

A Phase 2b Study of Baricitinib in Participants With Moderate to Severe Psoriasis

Eli Lilly and Company

NCT01490632

COMPLETED Phase 2 268 participants

Study to Evaluate Effectiveness and Safety in Subjects With Moderate to Severe Psoriasis

Bristol-Myers Squibb

NCT02931838

COMPLETED Phase 3 250 participants

Phase 3b Safety and Efficacy Study of Apremilast to Treat Moderate to Severe Plaque-plaque Psoriasis

Amgen

NCT01690299

COMPLETED Phase 3 234 participants

An Efficacy and Safety Study of Two Dose Levels of Certolizumab Pegol (CZP) in Subjects With Plaque Psoriasis (PSO)

UCB Biopharma S.P.R.L.

NCT02326298

COMPLETED 232 participants

Measuring the Treatment Preferences of Participants in Japan With Moderate-to-Severe Psoriasis (PsO) Using Discrete Choice Experiment

Bristol-Myers Squibb

NCT05065762

COMPLETED Phase 3 227 participants

A Study to Evaluate the Efficacy and Safety of Two Dose Levels of Certolizumab Pegol (CZP) in Subjects With Plaque Psoriasis (PSO)

UCB Biopharma S.P.R.L.

NCT02326272

COMPLETED Phase 2 199 participants

A Dose Ranging Study of the Effect of Ruxolitinib Phosphate Cream When Applied to Participants With Plaque Psoriasis

Incyte Corporation

NCT00778700

COMPLETED Phase 4 180 participants

A Study to Evaluate the Effect of Deucravacitinib on Quality of Life in Participants With Plaque Psoriasis in a Community Setting

Bristol-Myers Squibb

NCT05701995

COMPLETED Phase 2 166 participants

BI 655066 Dose Ranging in Psoriasis, Active Comparator Ustekinumab

Boehringer Ingelheim

NCT02054481

COMPLETED Phase 3 160 participants

A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

Amgen

NCT04175613

COMPLETED Phase 3 152 participants

Open Label Study of Adalimumab in Subjects Who Have a Sub-optimal Response to Systemic Therapy or Phototherapy

Abbott

NCT00566722

COMPLETED Phase 2 152 participants

Study to Evaluate the Efficacy and Safety of JTE-451 in Subjects With Moderate to Severe Plaque Psoriasis

Akros Pharma

NCT03832738

COMPLETED Phase 2 142 participants

A Study in Participants With Moderate to Severe Psoriasis

Eli Lilly and Company

NCT01107457

COMPLETED Phase 3 139 participants

A Study of Subcutaneous Risankizumab Injection for Pediatric Participants With Moderate to Severe Plaque Psoriasis to Assess Change in Disease Symptoms

AbbVie

NCT04435600

COMPLETED Phase 2 124 participants

A Study to Explore Efficacy and Safety of ASP015K in Subjects With Moderate to Severe Psoriasis

Astellas Pharma

NCT01096862

COMPLETED Phase 3 120 participants

Effects of Desoximetasone Spray 0.25% in Patients With Moderate to Severe Plaque Psoriasis

Sun Pharmaceutical Industries

NCT01206660

COMPLETED Phase 3 108 participants

A Study to Assess Usability of Risankizumab Autoinjector Combination Product in Participants With Moderate to Severe Plaque Psoriasis

AbbVie

NCT03875508

COMPLETED 103 participants

Serum, Cellular and Imaging Markers of Arthritis in Psoriasis Patients

University of Rochester

NCT02413801

COMPLETED Phase 2 99 participants

Randomized Study of PH-10 for Psoriasis

Provectus Pharmaceuticals

NCT01247818

COMPLETED Phase 1 94 participants

Topically Applied IDP-118 Lotion and HP Monad Lotion in Subjects With Moderate to Severe Plaque Psoriasis

Bausch Health Americas

NCT03058744

COMPLETED 86 participants

Genetic Analysis of Pediatric Psoriasis

Northwestern University

NCT03768284

COMPLETED NA 84 participants

Mind Matters: A High Touch, Low Cost Approach to Improving Mental Health Outcomes in Patients With Psoriatic Diseases

Elaine Husni

NCT05571696

COMPLETED Phase 3 78 participants

Efficacy and Safety Study of Guselkumab in the Treatment of Participants With Moderate to Severe Plaque-Type Psoriasis

Janssen Research & Development

NCT02905331

COMPLETED Phase 1 76 participants

Study Evaluating The Safety And Tolerability Of ILV-094 In Subjects With Psoriasis

Wyeth is now a wholly owned subsidiary of Pfizer

NCT00563524

COMPLETED Phase 2 66 participants

A Study of R3421 in Patients With Moderate to Severe Chronic Plaque Psoriasis.

Hoffmann-La Roche

NCT00504270

COMPLETED Phase 2 64 participants

Evaluation of Clinical Outcomes in an Online Teledermatology Model for the Management of Psoriasis

University of California, Davis

NCT00971477

COMPLETED 64 participants

Prevalence of Sleep Disturbances in Psoriasis

Wake Forest University Health Sciences

NCT00895375

COMPLETED Phase 4 63 participants

Olux E Foam and Sorilux Foam Combination Therapy for the Maintenance of Treatment Response in Patients With Moderate Plaque Psoriasis

Leon Kircik, M.D.

NCT01745133

COMPLETED 62 participants

Characterization of Lipoprotein Composition and Function in Pediatric Psoriasis Before and After Treatment

Northwestern University

NCT03791216

COMPLETED Phase 4 60 participants

Study of the Efficacy of Cloderm® Cream in the Treatment of Moderate Plaque Psoriasis

Promius Pharma

NCT01714544

COMPLETED 59 participants

Sleep, Circadian Rhythm & Skin Health

University Hospitals Cleveland Medical Center

NCT02457000

COMPLETED Phase 1 59 participants

Multiple Dose Escalation Study In Medically Stable Subjects With Psoriasis

Pfizer

NCT01736696

COMPLETED Phase 1 54 participants

An Investigational Study of Cyclosporine on Experimental Medication BMS-986165 in Healthy Male Participants

Bristol-Myers Squibb

NCT03419910

COMPLETED Phase 1 54 participants

A Safety, Tolerability and Pharmacokinetics Study of Topical Ointment YR001 in Adult Healthy Volunteers

Hangzhou Yirui Pharmaceutical Technology Co.

NCT05718921

COMPLETED Phase 1 49 participants

A Study to Evaluate BMS-986165 Tablet Formulation Relative to BMS-986165 Capsule Formulation and the Effect of a High-Fat/ High-Calorie Meal and Increased Gastric pH on the BMS-986165 Tablet Formulation

Bristol-Myers Squibb

NCT03254784

COMPLETED Phase 4 43 participants

Vascular Inflammation in Psoriasis-Ustekinumab (VIP-U)

University of Pennsylvania

NCT02187172

COMPLETED Phase 2 42 participants

A Study of Safety, Tolerability and Pharmacokinetics of Apremilast (CC-10004) in Pediatric Subjects With Moderate to Severe Plaque Psoriasis

Amgen

NCT02576678

COMPLETED Phase 2 40 participants

Study of the Clinical Activity, Safety, and Tolerability of SRT2104 in Subjects With Moderate to Severe Plaque-Type Psoriasis

Sirtris, a GSK Company

NCT01154101

COMPLETED Phase 1 40 participants

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of AbGn-168 in Psoriasis

Boehringer Ingelheim

NCT00848055

COMPLETED Phase 1 40 participants

Single Ascending Dose Study of PRX003 in Healthy Subjects

Prothena Biosciences Limited

NCT02458677

COMPLETED Phase 4 36 participants

MIcrovascular dysfuNction In Moderate-severe Psoriasis

Marcelo F. Di Carli, MD, FACC

NCT04271540

COMPLETED Phase 4 36 participants

The Quality of Life Study in Psoriasis Patients After Ustekinumab Treatment

University of California, San Francis

NCT01511315

Phase Distribution

PhaseTrial count
Phase 1 20
Phase 2 16
Phase 3 26
Phase 4 24

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Psoriasis Trial Landscape

ClinicalTrials.gov lists 127 US studies indexed under Psoriasis, and 26 of those are currently open to recruitment — roughly 20% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Psoriasis shows 50 late-stage studies (Phase 3 and Phase 4 combined) alongside 36 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Psoriasis is led by Bristol-Myers Squibb with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Psoriasis?

PlainTrial tracks 127 US clinical trials for Psoriasis, of which 26 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Psoriasis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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