Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Solid Tumors

Open-data reference.

127 US clinical trials · 43 currently recruiting

Active & Recent Trials

RECRUITING 99,999,999 participants

CIBMTR Research Database

Center for International Blood and Marrow Transplant Research

NCT01166009

RECRUITING Phase 3 3,500 participants

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Merck Sharp & Dohme

NCT03486873

RECRUITING 1,000 participants

PanTheR Registry Trial

RenovoRx

NCT06805461

RECRUITING Phase 2 920 participants

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

Hoffmann-La Roche

NCT04589845

RECRUITING Phase 1 710 participants

A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

Incyte Corporation

NCT06179160

RECRUITING Phase 1 604 participants

Study of INCB123667 in Subjects With Advanced Solid Tumors

Incyte Corporation

NCT05238922

RECRUITING Phase 2 497 participants

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Apollomics

NCT03175224

RECRUITING Phase 2 492 participants

DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

DualityBio

NCT06953089

RECRUITING Phase 1 475 participants

A Study of HS-20110 in Participants With Advanced Solid Tumors

Hansoh BioMedical R&D Company

NCT06892379

RECRUITING Phase 1 408 participants

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

Incyte Corporation

NCT05836324

RECRUITING Phase 1 385 participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Participants With Advanced Solid Tumors

GlaxoSmithKline

NCT06431594

RECRUITING Phase 1 362 participants

A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors

Arcus Biosciences

NCT05536141

RECRUITING Phase 1 350 participants

Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

ORIC Pharmaceuticals

NCT05315700

RECRUITING Phase 1 285 participants

Study of IBI3020 Treatment in Participants With Late-Stage Solid Tumors

Innovent Biopharmaceutical Technology (Hangzhou) Co.

NCT06963281

RECRUITING Phase 1 282 participants

S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors

Shionogi

NCT05101070

RECRUITING Phase 1 280 participants

A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

Incyte Corporation

NCT07195916

RECRUITING Phase 2 254 participants

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

Fore Biotherapeutics

NCT05503797

RECRUITING Phase 1 250 participants

QTX3034 in Patients With KRAS G12D Mutation

Quanta Therapeutics

NCT06227377

RECRUITING Phase 1 250 participants

Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)

EMD Serono Research & Development Institute

NCT06710132

RECRUITING 200 participants

Genomic Profiling in Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT01775072

RECRUITING Phase 1 190 participants

A Study to Test Different Doses of BI 1831169 Alone and in Combination With an Anti-PD-1 Antibody in People With Different Types of Advanced Cancer (Solid Tumors)

Boehringer Ingelheim

NCT05155332

RECRUITING Phase 1 180 participants

Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors

Zai Lab (Shanghai) Co.

NCT07374848

RECRUITING Phase 1 150 participants

A Study of XB371 Administered in Participants With Locally Advanced or Metastatic Solid Tumors

Exelixis

NCT07123103

RECRUITING Phase 1 150 participants

First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors

Daiichi Sankyo

NCT06644755

RECRUITING Phase 1 144 participants

JAB-30355 in Patients With Advanced Solid Tumors Harboring TP53 Y220C Mutation

Jacobio Pharmaceuticals Co.

NCT06386146

RECRUITING Phase 1 130 participants

Study of AUBE00 in Patients With Solid Tumors

Chugai Pharmaceutical

NCT07030959

RECRUITING Phase 1 112 participants

A Study of ZL-1310 in Participants With Selected Solid Tumors

Zai Lab (Shanghai) Co.

NCT06885281

RECRUITING Phase 1 103 participants

A Study of GEN1106 in Participants With Solid Tumors

Genmab

NCT07416123

RECRUITING Phase 1 102 participants

JAB-2485 Activity in Adult Patients With Advanced Solid Tumors

Jacobio Pharmaceuticals Co.

NCT05490472

RECRUITING Phase 1 100 participants

Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

Tyra Biosciences

NCT06915753

RECRUITING Phase 1 76 participants

ORIC-114 in Combination with Subcutaneous Amivantamab in Patients with EGFR Exon20 Insertion Mutant NSCLC

ORIC Pharmaceuticals

NCT06816992

RECRUITING Phase 1 68 participants

A Study of ADRX-0405 in Subjects With Select Advanced Solid Tumors

Adcentrx Therapeutics

NCT06710379

RECRUITING Phase 1 66 participants

A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)

Boehringer Ingelheim

NCT05471856

RECRUITING Phase 1 65 participants

ABL103 in Combination With Pembrolizumab, With or Without Taxane in Advanced or Metastatic Solid Tumors

ABL Bio

NCT07158918

RECRUITING Phase 1 65 participants

5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

National Cancer Institute (NCI)

NCT03366116

RECRUITING Phase 1 63 participants

A First-in-Human Study of BG-C0902 Alone and in Combination With Other Therapeutic Agents in Patients With Advanced Solid Tumors

BeOne Medicines

NCT07181681

RECRUITING Phase 1 54 participants

Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA)

M.D. Anderson Cancer Center

NCT06066424

RECRUITING Phase 4 46 participants

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

Pfizer

NCT05203172

RECRUITING Phase 1 41 participants

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

VLP Therapeutics

NCT06736379

RECRUITING Phase 2 40 participants

A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy

Spectrum Pharmaceuticals

NCT04570423

RECRUITING Phase 2 40 participants

Phase II Biomarker Study of SAR444881 in Combination With Cemiplimab in Solid Tumors

M.D. Anderson Cancer Center

NCT06651593

RECRUITING Phase 1 40 participants

DPTX3186 in Wnt Pathway Activated Solid Tumors

Dewpoint Therapeutics

NCT07312903

RECRUITING Phase 1 20 participants

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Valent Technologies

NCT04337177

ACTIVE NOT RECRUITING 14,266 participants

Mayo Clinic Radiotherapy Patient Outcomes Registry and Biobanking Study

Mayo Clinic

NCT02457962

ACTIVE NOT RECRUITING Phase 1 429 participants

GEN1046 Safety Trial in Patients With Malignant Solid Tumors

Genmab

NCT03917381

ACTIVE NOT RECRUITING Phase 2 300 participants

Study of Olaparib (MK-7339) in Combination With Pembrolizumab (MK-3475) in the Treatment of Homologous Recombination Repair Mutation (HRRm) and/or Homologous Recombination Deficiency (HRD)-Positive Advanced Cancer (MK-7339-007/KEYLYNK-007)

Merck Sharp & Dohme

NCT04123366

ACTIVE NOT RECRUITING Phase 1 253 participants

Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas

Taiho Oncology

NCT02503423

ACTIVE NOT RECRUITING Phase 3 205 participants

Avelumab Program Rollover Study

EMD Serono Research & Development Institute

NCT03815643

ACTIVE NOT RECRUITING Phase 1 195 participants

An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

Genentech

NCT04250155

ACTIVE NOT RECRUITING Phase 1 192 participants

A Study to Learn About the Study Medicine (Called PF-07220060 in Combination With PF-07104091) In Participants With Breast Cancer and Solid Tumors

Pfizer

NCT05262400

ACTIVE NOT RECRUITING Phase 1 165 participants

The Effects of Ginseng on Cancer-Related Fatigue

M.D. Anderson Cancer Center

NCT01375114

ACTIVE NOT RECRUITING Phase 1 161 participants

Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors

ModernaTX

NCT03313778

ACTIVE NOT RECRUITING Phase 1 144 participants

A Study of ADRX-0706 in Select Advanced Solid Tumors

Adcentrx Therapeutics

NCT06036121

ACTIVE NOT RECRUITING Phase 2 132 participants

Dexamethasone for Symptom Burden in Advanced Cancer Patients

M.D. Anderson Cancer Center

NCT00489307

ACTIVE NOT RECRUITING Phase 2 128 participants

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Pfizer

NCT03709680

ACTIVE NOT RECRUITING Phase 1 123 participants

A Study of Runimotamab in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers

Genentech

NCT03448042

ACTIVE NOT RECRUITING Phase 1 89 participants

A Study to Evaluate the Safety and Tolerability of ETC-1922159 as a Single Agent and in Combination With Pembrolizumab in Advanced Solid Tumours

EDDC (Experimental Drug Development Centre), A*STAR Research Entities

NCT02521844

ACTIVE NOT RECRUITING Phase 1 69 participants

Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options

Hoffmann-La Roche

NCT02650401

ACTIVE NOT RECRUITING Phase 3 68 participants

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

Pfizer

NCT05059522

ACTIVE NOT RECRUITING Early Phase 1 60 participants

Study of the Effects of Pre-surgical Aerobic Exercise on Patients With Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT03813615

ACTIVE NOT RECRUITING Phase 1 45 participants

Study of GS-9911 With or Without Antibody Treatment for Adults With Solid Tumors

Gilead Sciences

NCT06082960

ACTIVE NOT RECRUITING Phase 1 36 participants

A Study in People With Advanced Cancer to Test How Well Different Doses of BI 770371 Alone or in Combination With Ezabenlimab Are Tolerated

Boehringer Ingelheim

NCT05327946

ACTIVE NOT RECRUITING Phase 1 30 participants

A Study to Evaluate INCB186748 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

Incyte Corporation

NCT06818812

ACTIVE NOT RECRUITING Phase 1 28 participants

Research Study Utilizing Expanded Multi-antigen Specific Lymphocytes for the Treatment of Solid Tumors

Children's National Research Institute

NCT02789228

ACTIVE NOT RECRUITING Phase 1 18 participants

Cyclophosphamide Followed by Intravenous and Intraperitoneal Infusion of Autologous T Cells Genetically Engineered to Secrete IL-12 and to Target the MUC16ecto Antigen in Patients With Recurrent MUC16ecto+ Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT02498912

ACTIVE NOT RECRUITING Early Phase 1 17 participants

Study of Pembrolizumab Following Surgery in Patients With Microsatellite Instability High (MSI-H) Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT03832569

ACTIVE NOT RECRUITING Phase 1 9 participants

A Study to Evaluate INCB177054 in Participants With Select Advanced or Metastatic Solid Tumors

Incyte Corporation

NCT06873789

COMPLETED Phase 2 730 participants

Study of Cabozantinib (XL184) in Adults With Advanced Malignancies

Exelixis

NCT00940225

COMPLETED Phase 1 295 participants

An Investigational Immuno-therapy Study of Experimental Medication BMS-986156, Given by Itself or in Combination With Nivolumab in Patients With Solid Cancers or Cancers That Have Spread.

Bristol-Myers Squibb

NCT02598960

COMPLETED Phase 1 277 participants

Hormone Receptor Positive Disease Across Solid Tumor Types: A Phase I Study of Single-Agent Hormone Blockade and Combination Approaches With Targeted Agents to Provide Synergy and Overcome Resistance

M.D. Anderson Cancer Center

NCT01197170

COMPLETED Phase 1 260 participants

A Study Evaluating Bemarituzumab in Solid Tumors With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression

Amgen

NCT05325866

COMPLETED Phase 1 229 participants

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

Esperas Pharma

NCT02632448

COMPLETED Phase 1 184 participants

Phase 1b/2 Study of Carfilzomib in Relapsed Solid Tumors, Multiple Myeloma, or Lymphoma

Amgen

NCT00531284

COMPLETED Phase 2 176 participants

Allo Non-Myeloablative SCT Utilizing Mis-Matched Family Member Stem Cells Purged Using Campath

David Rizzieri, MD

NCT00580034

COMPLETED Phase 1 152 participants

A Study Evaluating Intermittent and Continuous OSI-906 and Weekly Paclitaxel in Patients With Recurrent Epithelial Ovarian Cancer (and Other Solid Tumors)

Astellas Pharma

NCT00889382

COMPLETED Phase 1 149 participants

A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors

Incyte Corporation

NCT03314935

COMPLETED Phase 1 119 participants

Combination Therapy With NC-6004 and Gemcitabine in Advanced Solid Tumors or Non-Small Cell Lung, Biliary and Bladder Cancer

NanoCarrier Co.

NCT02240238

COMPLETED Phase 1 106 participants

A Dose-escalation, Expansion Study of ARX788, in Advanced Solid Tumors Subjects With HER2 Expression (ACE-Pan Tumor 01)

Ambrx

NCT03255070

COMPLETED Phase 1 103 participants

AMG386 Comb w. Either Pegylated Liposomal Doxorubicin or Topotecan Subjects w. Advanced Recurrent Epithelial Ovarian CR

Amgen

NCT00770536

COMPLETED Phase 1 91 participants

Clinical Trial of ARQ 761 in Advanced Solid Tumors

University of Texas Southwestern Medical Center

NCT01502800

COMPLETED Phase 1 87 participants

Dose Escalation Study to Assess the Safety and Tolerability of Genz-644282 in Patients With Solid Tumors

Genzyme, a Sanofi Company

NCT00942799

COMPLETED Phase 2 84 participants

Brentuximab Vedotin in Patients With CD30-positive Nonlymphomatous Malignancies

Seagen

NCT01461538

COMPLETED Phase 1 83 participants

A Phase 1 Trial of CBL0137 in Patients With Metastatic or Unresectable Advanced Solid Neoplasm

Incuron

NCT01905228

COMPLETED Phase 1 73 participants

A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors

Pfizer

NCT04672460

COMPLETED Phase 1 70 participants

A Study of Intravenous (IV) Cergutuzumab Amunaleukin and Atezolizumab in Combination in Participants With Locally Advanced and/or Metastatic Solid Tumors

Hoffmann-La Roche

NCT02350673

COMPLETED Phase 2 70 participants

Reproducibility of 18F Uptake by Solid Tumors Using PET Imaging Following Intravenous Administration of (18F) Injection

GE Healthcare

NCT00918281

COMPLETED Phase 1 64 participants

A Study of Tor Kinase Inhibitor in Advanced Tumors

AstraZeneca

NCT00731263

COMPLETED Phase 1 64 participants

Dose Escalation, Multi-arm Study of MLN4924 Plus Docetaxel, Gemcitabine, or Combination of Carboplatin and Paclitaxel in Participants With Solid Tumors

Millennium Pharmaceuticals

NCT01862328

COMPLETED Phase 2 63 participants

Dose/ Schedule Finding Trial of Romiplostim for Chemotherapy-Induced Thrombocytopenia (CIT) in Non-Small Cell Lung Cancer (NSCLC)

Amgen

NCT00413283

COMPLETED Phase 1 60 participants

Phase I Study of IPI-504 and Docetaxel in Patients With Advanced Solid Tumors

Infinity Pharmaceuticals

NCT00606814

COMPLETED Phase 1 58 participants

Oral ONC201 in Treating Patients With Advanced Solid Tumors

Rutgers, The State University of New Jersey

NCT02250781

COMPLETED Phase 1 57 participants

Phase 1 Study Of Aurora Kinase Inhibitor PF-03814735 In Patients With Advanced Solid Tumors

Pfizer

NCT00424632

COMPLETED Phase 1 55 participants

Safety, Tolerability and Pharmacokinetic (PK) of Concomitant Esomeprazole and Rifampin, and QT Study on Single and Multiple-doses of Alisertib

Millennium Pharmaceuticals

NCT01844583

COMPLETED Phase 1 50 participants

Dasatinib in Combination With Bevacizumab to Treat Advanced Solid Tumors

National Cancer Institute (NCI)

NCT01445509

COMPLETED Phase 1 50 participants

Safety Study of Sterile Compound C31510 for Injection to Subjects With Solid Tumors

BPGbio

NCT01251562

COMPLETED Phase 2 48 participants

Allo Non-myeloablative SCT Utilizing Matched Family Member Stem Cells Purged Using Campath

David Rizzieri, MD

NCT00578942

COMPLETED Phase 1 48 participants

Phase I Study of CBP501 and Cisplatin in Patients With Advanced Refractory Solid Tumors

CanBas Co.

NCT00551512

COMPLETED Phase 1 46 participants

A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b

Nuvation Bio

NCT02279433

COMPLETED Phase 1 45 participants

Phase I Study of TAS-106 in Combo With Carboplatin

M.D. Anderson Cancer Center

NCT00752011

COMPLETED Phase 1 45 participants

Dose Finding, Safety and Tolerability Study for AC220 to Treat Advanced Solid Tumors

Daiichi Sankyo

NCT01049893

Phase Distribution

PhaseTrial count
Early Phase 1 102
Phase 2 15
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Solid Tumors Trial Landscape

ClinicalTrials.gov lists 127 US studies indexed under Solid Tumors, and 43 of those are currently open to recruitment — roughly 34% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Solid Tumors shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 117 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Solid Tumors is led by M.D. Anderson Cancer Center with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Solid Tumors?

PlainTrial tracks 127 US clinical trials for Solid Tumors, of which 43 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Solid Tumors?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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