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9-ING-41 in Patients with Advanced Cancers
NCT03678883 · View on ClinicalTrials.gov ↗
Study Summary
GSK-3β is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers.
Conditions Studied
Interventions
- DRUG Lomustine
- DRUG 9-ING-41
- DRUG Gemcitabine - 21 day cycle
- DRUG Doxorubicin.
- DRUG Carboplatin.
Study Locations (20)
Arizona
- Mayo Clinic — Phoenix
- Arizona Oncology Associates — Tucson
- The University of Arizona Cancer Center — Tucson
Florida
- Florida Cancer Specialists - South — Fort Myers
- Miami Cancer Institute — Miami
- Florida Cancer Specialists - North — St. Petersburg
California
- University of California Irvine Health — Orange
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco
Minnesota
- MetroMetro-Minnesota Community Oncology Research Consortium (MMCORC) — Minneapolis
- Mayo Clinic — Rochester
New Jersey
- Morristown Medical Center — Morristown
- Capital Health Medical Center/ Hopewell — Pennington
Delaware
- Christiana Care Health Services — Newark
District of Columbia
- Sibley Memorial Hospital — Washington D.C.
Illinois
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University — Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 350 participants |
| Start Date | 2019-01-04 |
| Est. Completion | 2026-01 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03678883
The ClinicalTrials.gov registry entry for NCT03678883 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 350 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Actuate Therapeutics, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Cancer appearing as the primary indexed condition, and to 5 interventions — of which Lomustine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03678883 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Arizona, Florida, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03678883 about?
NCT03678883 is a clinical study titled "9-ING-41 in Patients with Advanced Cancers". GSK-3β is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers.
What is the current status of trial NCT03678883?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 350 participants. The study started on 2019-01-04. Estimated completion is 2026-01.
What conditions does trial NCT03678883 study?
This clinical trial studies the following conditions: Cancer, Pancreatic Cancer, Sarcoma, Pancreatic Adenocarcinoma, Neoplasm Metastasis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03678883?
The interventions under investigation include: Lomustine (DRUG), 9-ING-41 (DRUG), Gemcitabine - 21 day cycle (DRUG), Doxorubicin. (DRUG), Carboplatin. (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03678883?
This trial is sponsored by Actuate Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03678883 being conducted?
This trial has 20 study locations across Arizona, California, Delaware, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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