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ClinicalTrials.gov 37 recruiting now official registry

Pulmonary Hypertension clinical trials

37 of 73 indexed Pulmonary Hypertension trials are currently recruiting.

73 US clinical trials · 37 currently recruiting

Pulmonary Hypertension is the subject of 73 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is United Therapeutics, running 4 of these trials.

The research picture

Pulmonary Hypertension has 73 registered US clinical trials, 37 of them open to new participants right now, about 51% of the total.

37
recruiting participants now
51%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
4
top sponsor: United Therapeutics
Phase 17Phase 216Phase 37Phase 44

Active & Recent Trials

73 total, page 1 of 2

RECRUITING 10,000 participants

Rutgers University Study of the Genetics of Pulmonary Hypertension

Rutgers, The State University of New Jersey

NCT07217522

RECRUITING 7,000 participants

CVD/PH and Voice Characteristics

Mayo Clinic

NCT07311044

RECRUITING 5,000 participants

Heart Institute Biobank & Registry for Adult Congenital Heart Disease and Related Disorders

Children's Hospital Medical Center, Cincinnati

NCT07477197

RECRUITING 3,000 participants

Pulmonary Hypertension in Left Heart Disease

Mayo Clinic

NCT05935605

RECRUITING 3,000 participants

Pulmonary Hypertension Association Registry

Pulmonary Hypertension Association

NCT04071327

RECRUITING 2,420 participants

Development of an Algorithm to Detect Pulmonary Hypertension Using an Electronic Stethoscope

Eko Devices

NCT05873387

RECRUITING 1,000 participants

DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

United Therapeutics

NCT06388421

RECRUITING NA 850 participants

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Abbott Medical Devices

NCT06526195

RECRUITING 450 participants

New Orleans Pulmonary Hypertension Biobank

Louisiana State University Health Sciences Center in New Orleans

NCT03269630

RECRUITING Phase 3 344 participants

Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Insmed Incorporated

NCT07179380

RECRUITING 300 participants

Pulmonary Hypertension Screening in Patients With Interstitial Lung Disease for Earlier Detection

United Therapeutics

NCT05776225

RECRUITING 300 participants

Pulmonary Hypertension Biorepository and Registry

University of Kansas Medical Center

NCT04808596

RECRUITING 270 participants

Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

National Institutes of Health Clinical Center (CC)

NCT01730092

RECRUITING Phase 1 260 participants

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Mario Castro, MD, MPH

NCT04624490

RECRUITING Phase 3 230 participants

LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF

Tenax Therapeutics

NCT05983250

RECRUITING Phase 2 180 participants

A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

Tectonic Therapeutic

NCT06616974

RECRUITING Phase 2 126 participants

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

VA Office of Research and Development

NCT05937854

RECRUITING 110 participants

Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients

Jiapeng Huang

NCT04756076

RECRUITING 100 participants

Prospective Validation of the Novel PVD-B65 Risk Score in Patients With Chronic Lung Disease and Pulmonary Hypertension

Temple University

NCT07151768

RECRUITING Phase 3 75 participants

Safety and Efficacy of FETO in CDH Phase III

Children's Hospital Medical Center, Cincinnati

NCT07187206

RECRUITING Phase 2 60 participants

Xenon MRI Pulm Hypertension

Bastiaan Driehuys

NCT04991454

RECRUITING 50 participants

Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure

Johns Hopkins University

NCT06299436

RECRUITING 50 participants

Observational Study of Patients Undergoing Diagnostic Right Heart Catheterization

HemoCept

NCT07224906

RECRUITING Phase 2 40 participants

A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)

University of Utah

NCT05201144

RECRUITING NA 40 participants

Feto-Endoscopic Tracheal Occlusion (FETO) for Severe Congenital Diaphragmatic Hernia

Children's Hospital Medical Center, Cincinnati

NCT02986087

RECRUITING Phase 2 36 participants

A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

Pfizer

NCT07073820

RECRUITING NA 36 participants

Identifying Right Ventricular Dysfunction in COPD Through Right Heart Catheterization, Imaging and Exercise

University of Colorado, Denver

NCT05896579

RECRUITING NA 30 participants

Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System

Aria CV

NCT04555161

RECRUITING NA 25 participants

Evaluating Infrasonic Hemodynography

Scripps Health

NCT04636892

RECRUITING NA 25 participants

iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH

Children's Hospital of Philadelphia

NCT05442671

RECRUITING Phase 2 20 participants

A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

Pulmovant

NCT07333183

RECRUITING Phase 2 20 participants

Bioenergetic Effect of Pioglitazone in CLD-PH

Emory University

NCT06336798

RECRUITING Phase 2 14 participants

129 Xenon Imaging in Patients Treated With Sotatercept

Bastiaan Driehuys

NCT06351345

RECRUITING Phase 2 10 participants

Metformin for Pulmonary Hypertension HFpEF

University of California, San Francisco

NCT03629340

RECRUITING Phase 2 8 participants

Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

Paul Szabolcs

NCT03630211

RECRUITING Phase 1 8 participants

Feasibility of Semaglutide in Advanced Lung Disease

University of Pennsylvania

NCT05746039

RECRUITING Phase 1 4 participants

Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension

Mayo Clinic

NCT06770023

ACTIVE NOT RECRUITING NA 1,000 participants

Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

Tempus AI

NCT06911632

ACTIVE NOT RECRUITING 230 participants

Activity Monitoring in Pulmonary Hypertension

Vanderbilt University Medical Center

NCT04101630

ACTIVE NOT RECRUITING 150 participants

Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass

University of Pennsylvania

NCT07132788

ACTIVE NOT RECRUITING Phase 2 135 participants

A Study of Mosliciguat in PH-ILD

Pulmovant

NCT06635850

ACTIVE NOT RECRUITING Phase 2 120 participants

Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD

Merck Sharp & Dohme

NCT05612035

ACTIVE NOT RECRUITING 100 participants

Trans-pulmonary Biomarkers in Pulmonary Hypertension

Vanderbilt University

NCT01961232

ACTIVE NOT RECRUITING 80 participants

An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH

Liquidia Technologies

NCT06129240

ACTIVE NOT RECRUITING Phase 4 31 participants

Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE

Northwell Health

NCT03581877

ACTIVE NOT RECRUITING Phase 2 10 participants

A Phase 2a Study of LAM-001 for the Treatment of Pulmonary Hypertension

OrphAI Therapeutics

NCT05798923

COMPLETED 3,993 participants

Pediatric Ventricle Function Assessment Study

HBI Solutions

NCT06739057

COMPLETED 1,000 participants

A Post-Marketing Study for On Label Evaluation of the GE Vscan Ultrasound Imaging System

GE Healthcare

NCT01076296

COMPLETED Phase 3 310 participants

Efficacy and Safety of Oral UT-15C Tablets to Treat Pulmonary Arterial Hypertension

United Therapeutics

NCT00887978

COMPLETED Phase 3 262 participants

A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH.

Bayer

NCT00855465

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 16
Phase 3 7
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pulmonary Hypertension Trial Landscape

73 indexed Pulmonary Hypertension studies · 37 recruiting (51%).

Phase mix: 11 late (III/IV) vs 23 early (I/II).

Top sponsor: United Therapeutics (4 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pulmonary Hypertension?

PlainTrial tracks 73 US clinical trials for Pulmonary Hypertension, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pulmonary Hypertension?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.