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NCT06299436 · ClinicalTrials.gov registry record
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
A clinical trial of Pulmonary Hypertension and Heart Failure With Reduced Ejection Fraction, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- 50
- Enrollment target
- 1
- Study location
NCT06299436: Recruiting study of Pulmonary Hypertension and Heart Failure With Reduced Ejection Fraction, sponsored by Johns Hopkins University.
NCT06299436 is a study of Pulmonary Hypertension and Heart Failure With Reduced Ejection Fraction that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 50 participants, below the 613-participant average among 72 other Pulmonary Hypertension trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06299436, a study of Pulmonary Hypertension and Heart Failure With Reduced Ejection Fraction, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV myocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV myocytes. The long-term goal of this proposal will be to better identify and treat RV failure in humans suffering from HFrEF-PH.
Primary Outcome
Diagnostic accuracy (AUC), as determined by combination of sensitivity and specificity, of multiple clinical metrics will be compared to determine which best identifies underlying right ventricular myocyte contractile dysfunction.
Conditions Studied
Study Locations (1)
Maryland
- Johns Hopkins Hospital - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2024-12-10 |
| Est. Completion | 2029-03-31 |
What NCT06299436 shows while recruiting
NCT06299436 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 613-participant average among 72 other Pulmonary Hypertension trials with a reported enrollment target (92% lower).
The record links to 3 conditions, with Pulmonary Hypertension appearing as the primary indexed condition, and to 0 interventions.
NCT06299436 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT06299436 about?
NCT06299436 is a clinical study titled "Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure". Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best cl...
What is the current status of trial NCT06299436?
This trial is currently recruiting. The enrollment target is 50 participants. The study started on 2024-12-10. Estimated completion is 2029-03-31.
What conditions does trial NCT06299436 study?
This clinical trial studies the following conditions: Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Right Heart Failure Due to Left Heart Failure.
Who is sponsoring clinical trial NCT06299436?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06299436 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pulmonary Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06299436's enrollment target sits among peer trials
50 40th of 72 higher than 32 of 72 other Pulmonary Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pulmonary Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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