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2026 data Public-data reference. official source

Neuroendocrine Tumors

Open-data reference.

53 US clinical trials · 27 currently recruiting

Active & Recent Trials

RECRUITING Phase 2 740 participants

Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors

National Cancer Institute (NCI)

NCT04074135

RECRUITING 300 participants

Tissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)

National Cancer Institute (NCI)

NCT05237934

RECRUITING Phase 3 288 participants

Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy

RayzeBio

NCT05477576

RECRUITING Phase 2 285 participants

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

National Cancer Institute (NCI)

NCT03412877

RECRUITING Phase 2 240 participants

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

Udai Kammula

NCT03935893

RECRUITING Phase 1 220 participants

Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies

Circle Pharma

NCT06577987

RECRUITING NA 200 participants

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

Case Comprehensive Cancer Center

NCT06263088

RECRUITING Phase 1 150 participants

A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors

Crinetics Pharmaceuticals

NCT07129252

RECRUITING Phase 1 135 participants

A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

Chimeric Therapeutics

NCT06055439

RECRUITING Phase 2 130 participants

Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma

National Cancer Institute (NCI)

NCT03206060

RECRUITING NA 120 participants

Addressing Social Determinants of Health Among Metro Detroit Cancer Survivors

Barbara Ann Karmanos Cancer Institute

NCT06908629

RECRUITING Phase 2 120 participants

177Lu-DOTATATE Modified Delivery Based on Individualized Dosimetry

University of Iowa

NCT06395402

RECRUITING Phase 2 111 participants

Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma and Neuroendocrine Tumors

Fox Chase Cancer Center

NCT05263050

RECRUITING Phase 2 86 participants

The Use of Guarana to Treat Fatigue in Patients With Neuroendocrine Tumors and Gynecologic Cancers (Guarana Fatigue)

University of Utah

NCT07151391

RECRUITING Phase 1 70 participants

A First-in-Human Phase I Trial With Antibody Drug Conjugate ADCT-701 in Neuroendocrine Tumors, Carcinomas and Malignant Peripheral Nerve Sheath Tumors

National Cancer Institute (NCI)

NCT06041516

RECRUITING Phase 2 70 participants

CapTemY90 for Grade 2/3 NET Liver Metastases

Abramson Cancer Center at Penn Medicine

NCT04339036

RECRUITING Phase 1 67 participants

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

Novelty Nobility

NCT06805825

RECRUITING Phase 1 56 participants

Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)

National Cancer Institute (NCI)

NCT04086485

RECRUITING 50 participants

Peptide Receptor Radionuclide Therapy (PRRT) for the Treatment of Neuroendocrine Tumors

Methodist Health System

NCT04090034

RECRUITING Phase 1 36 participants

SVV-001 With Nivolumab and Ipilimumab in Patients With Poorly Differentiated Neuroendocrine Carcinomas (NEC) or Well-Differentiated High-Grade Neuroendocrine Tumors (NET)

Peter Hosein, MD

NCT06889493

RECRUITING Phase 2 29 participants

Lenvatinib Plus Pembrolizumab in Well Differentiated G3 Neuroendocrine Tumors

University of California, San Francis

NCT05746208

RECRUITING Phase 1 25 participants

Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

Teclison

NCT02174549

RECRUITING Phase 1 24 participants

F-Tryptophan PET/CT in Human Cancers

Barbara Ann Karmanos Cancer Institute

NCT05556473

RECRUITING Phase 2 21 participants

Trial of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pancreas Who Have Not Received Prior Treatment With mTOR Inhibitors

Aadi Bioscience

NCT05997056

RECRUITING Phase 1 18 participants

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

Anusha Kalbasi

NCT04119024

RECRUITING Phase 1 10 participants

Using Novel Imaging to More Safely Treat Neuroendocrine Tumors

University of Wisconsin, Madison

NCT06122610

RECRUITING Phase 1 9 participants

177Lu-DOTA-EB-TATE in Adult Patients With Advanced, Well- Differentiated Neuroendocrine Tumors

Molecular Targeting Technologies

NCT05475210

ACTIVE NOT RECRUITING 2,539 participants

Neuroendocrine Tumors - Patient Reported Outcomes

University of Iowa

NCT05064150

ACTIVE NOT RECRUITING 1,014 participants

Post-Authorization Long-Term Safety Study of LUTATHERA

Advanced Accelerator Applications

NCT03691064

ACTIVE NOT RECRUITING Phase 2 534 participants

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

Hoffmann-La Roche

NCT02568267

ACTIVE NOT RECRUITING Phase 3 309 participants

Efficacy and Safety of 177Lu-edotreotide PRRT in GEP-NET Patients

ITM Solucin

NCT03049189

ACTIVE NOT RECRUITING Phase 3 259 participants

Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) - COMPOSE

ITM Solucin

NCT04919226

ACTIVE NOT RECRUITING Phase 1 141 participants

A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies

23andMe

NCT05199272

ACTIVE NOT RECRUITING Phase 2 69 participants

Targeted Alpha-emitter Therapy of PRRT Naïve and Previous PRRT Neuroendocrine Tumor Patients

Orano Med

NCT05153772

ACTIVE NOT RECRUITING Phase 2 55 participants

Nivolumab and Temozolomide in Treating Patients With Recurrent or Refractory Small-Cell Lung Cancer or Advanced Neuroendocrine Cancer

Dwight Owen

NCT03728361

ACTIVE NOT RECRUITING Phase 2 45 participants

Pembrolizumab and Lenvatinib in Advanced/Metastatic Neuroendocrine Prostate Cancer

University of Michigan Rogel Cancer Center

NCT04848337

ACTIVE NOT RECRUITING Early Phase 1 30 participants

Gallium 68 Pentixafor in Patients With Neuroendocrine Tumors

Yusuf Menda

NCT03335670

ACTIVE NOT RECRUITING Early Phase 1 24 participants

A Safety Study of 212Pb-VMT-alpha-NET in Patients With Neuroendocrine Tumors

David Bushnell

NCT06148636

ACTIVE NOT RECRUITING NA 12 participants

Lipiodol Deposition Using Endhole vs. Pressure-Modulated Delivery

Abramson Cancer Center at Penn Medicine

NCT06204159

ACTIVE NOT RECRUITING 11 participants

Defining Response Criteria for PET Scans for People With Neuroendocrine Tumors

Memorial Sloan Kettering Cancer Center

NCT06448208

ACTIVE NOT RECRUITING Early Phase 1 10 participants

Lutathera in People With Gastroenteropancreatic (GEP), Bronchial or Unknown Primary Neuroendocrine Tumors That Have Spread to the Liver

Memorial Sloan Kettering Cancer Center

NCT04544098

ACTIVE NOT RECRUITING Phase 1 6 participants

Study of Cabozantinib With Lu-177 in Patients With Somatostatin Receptor 2 Positive Neuroendocrine Tumors

Providence Health & Services

NCT05249114

COMPLETED 183 participants

EchoTip AcuCore Post-Market Clinical Study

Cook Research Incorporated

NCT06358001

COMPLETED Phase 2 122 participants

Impact of Ga-68 DOTATOC PET-CT Imaging in Management of Neuroendocrine Tumors

Sue O'Dorisio

NCT02441062

COMPLETED Early Phase 1 100 participants

Impact of 68Ga-DOTATATE PET/CT on the Management of Neuroendocrine Tumors: The Referring Physician's Perspective

Jonsson Comprehensive Cancer Center

NCT01873248

COMPLETED Phase 1 68 participants

A Dose Finding Study of TKM-080301 Infusion in Neuroendocrine Tumors (NET) and Adrenocortical Carcinoma (ACC) Patients

Arbutus Biopharma Corporation

NCT01262235

COMPLETED NA 50 participants

Dual-Tracer Theranostic PET

University of Utah

NCT05680675

COMPLETED Phase 1 48 participants

18F-MFBG Imaging for Evaluation of Neuroendocrine Malignancies

Memorial Sloan Kettering Cancer Center

NCT02348749

COMPLETED Phase 2 34 participants

Bevacizumab in Combination With Temozolomide in Patients With Neuroendocrine Tumors

Dana-Farber Cancer Institute

NCT00137774

COMPLETED Phase 2 25 participants

Quarfloxin in Patients With Low to Intermediate Grade Neuroendocrine Carcinoma

Cylene Pharmaceuticals

NCT00780663

COMPLETED Phase 2 21 participants

A Study of Pembrolizumab in Patients With Neuroendocrine Tumors

Fox Chase Cancer Center

NCT02939651

COMPLETED Phase 2 15 participants

Lithium for Low-Grade Neuroendocrine Tumors

University of Wisconsin, Madison

NCT00501540

COMPLETED Phase 1 13 participants

Pasireotide, Everolimus and Selective Internal Radioembolization Therapy for Unresectable Hepatic Metastases

Emory University

NCT01469572

Phase Distribution

PhaseTrial count
Early Phase 1 21
Phase 2 19
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Neuroendocrine Tumors Trial Landscape

ClinicalTrials.gov lists 53 US studies indexed under Neuroendocrine Tumors, and 27 of those are currently open to recruitment — roughly 51% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Neuroendocrine Tumors shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 40 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Neuroendocrine Tumors is led by National Cancer Institute (NCI) with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 53 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Neuroendocrine Tumors?

PlainTrial tracks 53 US clinical trials for Neuroendocrine Tumors, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Neuroendocrine Tumors?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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