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NCT04991454 · ClinicalTrials.gov registry record · Phase 2
Xenon MRI Pulm Hypertension
A Phase 2 study of Pulmonary Hypertension and Pulmonary Arterial Hypertension, sponsored by Bastiaan Driehuys.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT04991454: Recruiting Phase 2 study of Pulmonary Hypertension and Pulmonary Arterial Hypertension, sponsored by Bastiaan Driehuys.
NCT04991454 is a Phase 2 study of Pulmonary Hypertension and Pulmonary Arterial Hypertension that is actively recruiting participants, run by Bastiaan Driehuys. The registered enrollment target is 60 participants, below the 613-participant average among 72 other Pulmonary Hypertension trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04991454, a Phase 2 study of Pulmonary Hypertension and Pulmonary Arterial Hypertension, is actively recruiting participants, sponsored by Bastiaan Driehuys.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall objective outlined in this study is to determine how pulmonary vascular remodeling in PAH at a cellular and pathological level is associated with changes in gas exchange physiology and hemodynamics (monitored with 129Xe MRI/MRS) and how these signals change with disease progression or treatment.
Primary Outcome
The study team will determine whether the correlation between Red Blood Cell Signal from Xenon MRI to pathologic scoring of pulmonary vascular remodeling from histopathology is statistically significant.
Conditions Studied
Interventions
- DRUG 129Xe Hyperpolarized
Study Locations (1)
North Carolina
- Duke University Medical Center - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2021-09-01 |
| Est. Completion | 2026-08-30 |
| Phase | Phase 2 |
What NCT04991454 shows while recruiting
NCT04991454 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 613-participant average among 72 other Pulmonary Hypertension trials with a reported enrollment target (90% lower).
The record links to 2 conditions, with Pulmonary Hypertension appearing as the primary indexed condition, and to 1 intervention - of which 129Xe Hyperpolarized is the first listed.
NCT04991454 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT04991454 about?
NCT04991454 is a clinical study titled "Xenon MRI Pulm Hypertension". The overall objective outlined in this study is to determine how pulmonary vascular remodeling in PAH at a cellular and pathological level is associated with changes in gas exchange physiology and hemodynamics (monitored with 129Xe MRI/MRS) and how these signals change with disease progression or tr...
What is the current status of trial NCT04991454?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2021-09-01. Estimated completion is 2026-08-30.
What conditions does trial NCT04991454 study?
This clinical trial studies the following conditions: Pulmonary Hypertension, Pulmonary Arterial Hypertension.
What interventions are being tested in trial NCT04991454?
The interventions under investigation include: 129Xe Hyperpolarized (DRUG).
Who is sponsoring clinical trial NCT04991454?
This trial is sponsored by Bastiaan Driehuys, which has 16 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04991454 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pulmonary Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04991454's enrollment target sits among peer trials
60 37th of 72 higher than 36 of 72 other Pulmonary Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pulmonary Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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