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ClinicalTrials.gov 37 recruiting now official registry

Pulmonary Hypertension clinical trials

37 of 73 indexed Pulmonary Hypertension trials are currently recruiting.

73 US clinical trials · 37 currently recruiting

Pulmonary Hypertension is the subject of 73 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is United Therapeutics, running 4 of these trials.

The research picture

Pulmonary Hypertension has 73 registered US clinical trials, 37 of them open to new participants right now, about 51% of the total.

37
recruiting participants now
51%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
4
top sponsor: United Therapeutics
Phase 17Phase 216Phase 37Phase 44

Active & Recent Trials

73 total, page 2 of 2

COMPLETED Phase 3 235 participants

Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH)

United Therapeutics

NCT00147199

COMPLETED 209 participants

Tricuspid Regurgitant Jet Velocity as an Independent Marker for Mortality in Sickle Cell Anemia

Namita Sood

NCT01783093

COMPLETED Phase 3 185 participants

Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II

Actelion

NCT00091715

COMPLETED 120 participants

Heart Disease in Sickle Cell Anemia

National Institutes of Health Clinical Center (CC)

NCT00113152

COMPLETED 71 participants

The Study Of CT Scans and Echo Parameters in Patients With PAH

Northwell Health

NCT00625963

COMPLETED Phase 1 59 participants

Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension

National Heart, Lung, and Blood Institute (NHLBI)

NCT00023296

COMPLETED 56 participants

Frailty in Children With Cardiac Disease

Children's Mercy Hospital Kansas City

NCT02999438

COMPLETED NA 35 participants

Noninvasive Cardiac Output Monitoring in Pulmonary Hypertension

Santa Barbara Cottage Hospital

NCT02951104

COMPLETED Phase 1 31 participants

Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension

National Heart, Lung, and Blood Institute (NHLBI)

NCT00352430

COMPLETED 29 participants

Pulmonary Hypertension, Hypoxia and Sickle Cell Disease

National Heart, Lung, and Blood Institute (NHLBI)

NCT00495638

COMPLETED Phase 4 25 participants

A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis

Johns Hopkins University

NCT01042158

COMPLETED NA 24 participants

Does Sildenafil Increase Exercise Performance in Air Pollution?

Marywood University

NCT00808912

COMPLETED NA 24 participants

Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability

University of North Carolina, Chapel Hill

NCT01615484

COMPLETED 24 participants

Cardiac MRI in Pulmonary Hypertension

University of California, San Francisco

NCT02485977

COMPLETED Phase 2 21 participants

11C-acetate/18Fluorodeoxyglucose-FDG PET/CT and Cardiac MRI in Pulmonary Hypertension

University of Pennsylvania

NCT01917136

COMPLETED Phase 1 20 participants

Effect of Bosentan on Exercise Capacity at High Altitude

VA Loma Linda Health Care System

NCT00432978

COMPLETED Phase 1 20 participants

Iloprost Effects on Gas Exchange and Pulmonary Mechanics

University of Oklahoma

NCT01274481

COMPLETED 20 participants

Effect of Endothelin-1 Receptor Blockade on Circulating Endothelial Microparticles Levels in Patients With Pulmonary Hypertension

University of California, San Francisco

NCT00675051

COMPLETED Phase 2 17 participants

Investigation of H01 in Adults With Pulmonary Hypertension Including Interstitial Lung Disease (The SATURN Study).

Stanford University

NCT05128929

COMPLETED Phase 2 16 participants

Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary Hypertension

Medical University of South Carolina

NCT00851929

COMPLETED Phase 4 12 participants

Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan

University of California, Los Angeles

NCT01051960

COMPLETED Phase 4 10 participants

Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction

Boston University

NCT02133352

COMPLETED NA 6 participants

Cognitive Behavioral Therapy and Light Therapy

University of Pennsylvania

NCT05337943

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 16
Phase 3 7
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pulmonary Hypertension Trial Landscape

73 indexed Pulmonary Hypertension studies · 37 recruiting (51%).

Phase mix: 11 late (III/IV) vs 23 early (I/II).

Top sponsor: United Therapeutics (4 trials), 9 others listed. 23 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pulmonary Hypertension?

PlainTrial tracks 73 US clinical trials for Pulmonary Hypertension, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pulmonary Hypertension?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.