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Pulmonary Hypertension: early-phase trial registry
37 of 73 indexed Pulmonary Hypertension trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #188 of 28,707 conditions by registered trial count.
73 US clinical trials · 37 currently recruiting · #188 of 28,707 conditions by registered trial count
Pulmonary Hypertension: 73 US clinical trials tracked, 37 recruiting.
Pulmonary Hypertension is the subject of 73 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is United Therapeutics, running 4 of these trials.
Enrollment posture brief
Registry condition pulmonary-hypertension
OPEN 37 | RECR 51% | LATE 11 | EARLY 23 | RANK #188 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Neuroendocrine Tumors (51% recruiting · 53 trials)
Pulmonary Hypertension lists 37 open slots (51% of 73 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pulmonary Hypertension on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pulmonary Hypertension is recruiting above its size-band peers.
37 of 73 indexed trials (50.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pulmonary Hypertension trials is spread across many organizations.
United Therapeutics accounts for 4 of 73 trials (5.5%). 54 distinct sponsors appear on at least one study for this condition label.
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Typical Pulmonary Hypertension enrolment sits around 60 participants.
Median target enrolment is 60 among the 73 trials that report a genuine target (sentinel values excluded). 40 of those (54.8%) plan for fewer than 100 participants.
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Pulmonary Hypertension splits between interventional and observational designs.
45 interventional and 28 observational studies make up this index (61.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
73 total, page 2 of 2
Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH)
United Therapeutics
NCT00147199
Tricuspid Regurgitant Jet Velocity as an Independent Marker for Mortality in Sickle Cell Anemia
Namita Sood
NCT01783093
Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II
Actelion
NCT00091715
Heart Disease in Sickle Cell Anemia
National Institutes of Health Clinical Center (CC)
NCT00113152
The Study Of CT Scans and Echo Parameters in Patients With PAH
Northwell Health
NCT00625963
Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension
National Heart, Lung, and Blood Institute (NHLBI)
NCT00023296
Frailty in Children With Cardiac Disease
Children's Mercy Hospital Kansas City
NCT02999438
Noninvasive Cardiac Output Monitoring in Pulmonary Hypertension
Santa Barbara Cottage Hospital
NCT02951104
Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension
National Heart, Lung, and Blood Institute (NHLBI)
NCT00352430
Pulmonary Hypertension, Hypoxia and Sickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI)
NCT00495638
A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis
Johns Hopkins University
NCT01042158
Does Sildenafil Increase Exercise Performance in Air Pollution?
Marywood University
NCT00808912
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
University of North Carolina, Chapel Hill
NCT01615484
Cardiac MRI in Pulmonary Hypertension
University of California, San Francisco
NCT02485977
11C-acetate/18Fluorodeoxyglucose-FDG PET/CT and Cardiac MRI in Pulmonary Hypertension
University of Pennsylvania
NCT01917136
Effect of Bosentan on Exercise Capacity at High Altitude
VA Loma Linda Health Care System
NCT00432978
Iloprost Effects on Gas Exchange and Pulmonary Mechanics
University of Oklahoma
NCT01274481
Effect of Endothelin-1 Receptor Blockade on Circulating Endothelial Microparticles Levels in Patients With Pulmonary Hypertension
University of California, San Francisco
NCT00675051
Investigation of H01 in Adults With Pulmonary Hypertension Including Interstitial Lung Disease (The SATURN Study).
Stanford University
NCT05128929
Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary Hypertension
Medical University of South Carolina
NCT00851929
Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan
University of California, Los Angeles
NCT01051960
Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction
Boston University
NCT02133352
Cognitive Behavioral Therapy and Light Therapy
University of Pennsylvania
NCT05337943
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 16 |
| Phase 3 | 7 |
| Phase 4 | 4 |
Top Sponsors
Named interventions
Most-linked intervention names on Pulmonary Hypertension records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pulmonary Hypertension trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pulmonary Hypertension page
73 registered trials, 37 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 37 Pulmonary Hypertension trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- United Therapeutics sponsors the most Pulmonary Hypertension trials on record, review their full trial history before evaluating a specific study. See United Therapeutics's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pulmonary Hypertension condition card totals 73 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.