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Pulmonary Hypertension clinical trials
37 of 73 indexed Pulmonary Hypertension trials are currently recruiting.
73 US clinical trials · 37 currently recruiting
Pulmonary Hypertension is the subject of 73 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is United Therapeutics, running 4 of these trials.
The research picture
Pulmonary Hypertension has 73 registered US clinical trials, 37 of them open to new participants right now, about 51% of the total.
- 37
- recruiting participants now
- 51%
- of trials open to enrollment
- 11
- in Phase 3–4 (later-stage)
- 4
- top sponsor: United Therapeutics
Active & Recent Trials
73 total, page 2 of 2
Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH)
United Therapeutics
NCT00147199
Tricuspid Regurgitant Jet Velocity as an Independent Marker for Mortality in Sickle Cell Anemia
Namita Sood
NCT01783093
Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II
Actelion
NCT00091715
Heart Disease in Sickle Cell Anemia
National Institutes of Health Clinical Center (CC)
NCT00113152
The Study Of CT Scans and Echo Parameters in Patients With PAH
Northwell Health
NCT00625963
Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension
National Heart, Lung, and Blood Institute (NHLBI)
NCT00023296
Frailty in Children With Cardiac Disease
Children's Mercy Hospital Kansas City
NCT02999438
Noninvasive Cardiac Output Monitoring in Pulmonary Hypertension
Santa Barbara Cottage Hospital
NCT02951104
Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension
National Heart, Lung, and Blood Institute (NHLBI)
NCT00352430
Pulmonary Hypertension, Hypoxia and Sickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI)
NCT00495638
A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis
Johns Hopkins University
NCT01042158
Does Sildenafil Increase Exercise Performance in Air Pollution?
Marywood University
NCT00808912
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
University of North Carolina, Chapel Hill
NCT01615484
Cardiac MRI in Pulmonary Hypertension
University of California, San Francisco
NCT02485977
11C-acetate/18Fluorodeoxyglucose-FDG PET/CT and Cardiac MRI in Pulmonary Hypertension
University of Pennsylvania
NCT01917136
Effect of Bosentan on Exercise Capacity at High Altitude
VA Loma Linda Health Care System
NCT00432978
Iloprost Effects on Gas Exchange and Pulmonary Mechanics
University of Oklahoma
NCT01274481
Effect of Endothelin-1 Receptor Blockade on Circulating Endothelial Microparticles Levels in Patients With Pulmonary Hypertension
University of California, San Francisco
NCT00675051
Investigation of H01 in Adults With Pulmonary Hypertension Including Interstitial Lung Disease (The SATURN Study).
Stanford University
NCT05128929
Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary Hypertension
Medical University of South Carolina
NCT00851929
Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan
University of California, Los Angeles
NCT01051960
Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction
Boston University
NCT02133352
Cognitive Behavioral Therapy and Light Therapy
University of Pennsylvania
NCT05337943
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 16 |
| Phase 3 | 7 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Pulmonary Hypertension Trial Landscape
73 indexed Pulmonary Hypertension studies · 37 recruiting (51%).
Phase mix: 11 late (III/IV) vs 23 early (I/II).
Top sponsor: United Therapeutics (4 trials), 9 others listed. 23 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Pulmonary Hypertension?
PlainTrial tracks 73 US clinical trials for Pulmonary Hypertension, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Pulmonary Hypertension?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.