Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Solid Tumor, Adult

Open-data reference.

73 US clinical trials · 48 currently recruiting

Active & Recent Trials

RECRUITING 1,500 participants

A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.

BioCytics

NCT00571389

RECRUITING Phase 1 930 participants

First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

Relay Therapeutics

NCT05216432

RECRUITING 500 participants

Personalized Models for Cancer Research

New York Stem Cell Foundation Research Institute

NCT06350539

RECRUITING Phase 1 474 participants

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT06051695

RECRUITING Phase 1 403 participants

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

Frontier Medicines Corporation

NCT06244771

RECRUITING Phase 1 392 participants

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

NCT06625775

RECRUITING Phase 1 375 participants

ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

Immatics US

NCT03686124

RECRUITING Phase 1 365 participants

A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

GV20 Therapeutics

NCT05669430

RECRUITING Phase 1 360 participants

First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors

DualityBio

NCT06554795

RECRUITING Phase 1 348 participants

A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors

Corbus Pharmaceuticals

NCT06265727

RECRUITING Phase 1 336 participants

Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

Vivace Therapeutics

NCT04665206

RECRUITING Phase 1 295 participants

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

Verastem

NCT07020221

RECRUITING NA 285 participants

Psychotherapy Intervention for Latinos With Adv Cancer

Memorial Sloan Kettering Cancer Center

NCT04537936

RECRUITING Phase 1 250 participants

A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs

Krystal Biotech

NCT06228326

RECRUITING Phase 1 240 participants

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT06682793

RECRUITING NA 234 participants

Adapting for Latinx Populations an Intervention That Involves Discussing and Sharing Patients' Health-Related Values

Memorial Sloan Kettering Cancer Center

NCT04942717

RECRUITING Phase 1 230 participants

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

Nested Therapeutics

NCT06326411

RECRUITING Phase 2 200 participants

Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT04165772

RECRUITING Phase 1 200 participants

Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab

Linnaeus Therapeutics

NCT04130516

RECRUITING 200 participants

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

A2 Biotherapeutics

NCT04981119

RECRUITING Phase 1 197 participants

A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

BioInvent International AB

NCT04219254

RECRUITING NA 190 participants

Psychotherapy Intervention for Latinos With Advanced Cancer

Memorial Sloan Kettering Cancer Center

NCT04015609

RECRUITING Phase 1 160 participants

First In Human Study of CX-2051 in Advanced Solid Tumors

CytomX Therapeutics

NCT06265688

RECRUITING Phase 1 150 participants

A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

NiKang Therapeutics

NCT06586957

RECRUITING Phase 2 140 participants

A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors

EpicentRx

NCT04673942

RECRUITING Phase 1 130 participants

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

Sairopa B.V.

NCT05856981

RECRUITING NA 125 participants

DESCANSO, a Mental Health Intervention for Depression, Insomnia, and Fatigue Symptoms in Latino People With Cancer

Memorial Sloan Kettering Cancer Center

NCT07225088

RECRUITING Phase 1 121 participants

First In Human Study of CX-801 in Advanced Solid Tumors

CytomX Therapeutics

NCT06462794

RECRUITING Phase 1 108 participants

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

AstraZeneca

NCT06218914

RECRUITING Phase 1 100 participants

Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

Tyra Biosciences

NCT06915753

RECRUITING NA 100 participants

Clinical Nurse Specialist Led Early Palliative Survivorship Care for Patients With Advanced Cancer

Good Samaritan Hospital Medical Center, New York

NCT05947695

RECRUITING Phase 1 100 participants

A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

Kumquat Biosciences

NCT06507306

RECRUITING Phase 1 94 participants

Open-Label, Dose-Escalation With Expansion to Assess the Safety, Tolerability, and PK of TRE-515 in Subjects With Solid Tumors

Trethera

NCT05055609

RECRUITING Phase 1 91 participants

64Cu-GRIP B in Patients With Advanced Malignancies

Rahul Aggarwal

NCT05888532

RECRUITING NA 85 participants

Intravital Microscopy in Human Solid Tumors

Mayo Clinic

NCT03823144

RECRUITING Phase 1 83 participants

Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca

Virginia Commonwealth University

NCT03919292

RECRUITING Phase 1 78 participants

A Study to Determine the Effect of CT3001 in Patients with Advanced Solid Tumors

Crossignal Therapeutics

NCT06598007

RECRUITING Phase 1 78 participants

An Open-Label Study of INV-1120 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Advanced Solid Tumors

Shenzhen Ionova Life Sciences Co.

NCT04443088

RECRUITING Phase 1 76 participants

COAST Therapy in Advanced Solid Tumors and Prostate Cancer

Medical University of South Carolina

NCT05036226

RECRUITING Phase 1 60 participants

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

BioEclipse Therapeutics

NCT04282044

RECRUITING NA 60 participants

A Pilot Study of Genetic Testing Uptake Through Enhanced Oncology Nurse-Led Intervention

University of California, Davis

NCT06436157

RECRUITING Phase 1 60 participants

A Study of VET3-TGI in Patients With Solid Tumors

KaliVir Immunotherapeutics

NCT06444815

RECRUITING Phase 1 50 participants

Advanced or Recurrent Solid Tumors Treated With SHetA2

University of Oklahoma

NCT04928508

RECRUITING Phase 1 50 participants

BP1001-A in Patients With Advanced or Recurrent Solid Tumors

Bio-Path Holdings

NCT04196257

RECRUITING Phase 1 45 participants

Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)

University of Texas Southwestern Medical Center

NCT07139990

RECRUITING Phase 1 39 participants

Trial of Nivolumab Following Partially Human Leukocyte Antigen (HLA) Mismatched BMT in Children & Adults With Sarcoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03465592

RECRUITING Phase 1 33 participants

R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors

Rise Therapeutics

NCT06398418

RECRUITING Phase 1 30 participants

Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies

Effector Therapeutics

NCT04092673

ACTIVE NOT RECRUITING NA 510 participants

Developing a Virtual Stress Management Intervention for Spousal/Partnered Caregivers of Solid Tumor Cancer Patients.

University of Colorado, Denver

NCT04739696

ACTIVE NOT RECRUITING Phase 1 400 participants

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

Pierre Fabre Medicament

NCT04913285

ACTIVE NOT RECRUITING Phase 1 310 participants

Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations

Tyra Biosciences

NCT05544552

ACTIVE NOT RECRUITING Phase 1 292 participants

First-in-Human Study of ICT01 in Patients With Advanced Cancer

ImCheck Therapeutics

NCT04243499

ACTIVE NOT RECRUITING Phase 1 180 participants

Study to Evaluate D-1553 in Subjects With Solid Tumors

InventisBio Co.

NCT04585035

ACTIVE NOT RECRUITING Phase 1 160 participants

A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT05736731

ACTIVE NOT RECRUITING Phase 1 130 participants

Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors

Cybrexa Therapeutics

NCT04902872

ACTIVE NOT RECRUITING Phase 1 120 participants

Study of DECOY20 With or Without Tislelizumab in Patients With Advanced Solid Tumors

Indaptus Therapeutics

NCT05651022

ACTIVE NOT RECRUITING Phase 1 115 participants

Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors

Nouscom SRL

NCT04041310

ACTIVE NOT RECRUITING Phase 1 98 participants

A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

Sensei Biotherapeutics

NCT05864144

ACTIVE NOT RECRUITING Phase 1 77 participants

A Study of HST-1011 Given as Monotherapy and in Combination With an Anti-PD1 Antibody

HotSpot Therapeutics

NCT05662397

ACTIVE NOT RECRUITING Phase 1 56 participants

Evaluation of AL3818 in Combination With Nivolumab in Solid Tumors

Sarcoma Oncology Research Center

NCT04165330

ACTIVE NOT RECRUITING Phase 1 54 participants

A Study of AZD1390 and Stereotactic Body Radiotherapy (SBRT) for People With Metastatic Solid Tumor Cancer

Memorial Sloan Kettering Cancer Center

NCT05678010

ACTIVE NOT RECRUITING Phase 1 52 participants

A Study to Assess AXN-2510 Treatment in Adult Patients With Advanced Solid Tumors

Axion Bio

NCT07159828

ACTIVE NOT RECRUITING Phase 2 51 participants

Study of Benralizumab in People With Skin Side Effects Caused by Cancer Therapies

Memorial Sloan Kettering Cancer Center

NCT04552288

ACTIVE NOT RECRUITING Phase 1 42 participants

A Monotherapy in Subjects With Advanced Solid Tumors

3D Medicines (Beijing) Co.

NCT04221204

ACTIVE NOT RECRUITING Phase 1 2 participants

A Rollover Study for Subjects Who Completed Participation in IMSA101-101 Trial

ImmuneSensor Therapeutics

NCT06026254

COMPLETED Phase 1 78 participants

A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma

Ikena Oncology

NCT04200963

COMPLETED Phase 2 52 participants

Pembrolizumab Activity in Patients With Homologous Recombination Competent and Deficient Tumors

Baptist Health South Florida

NCT03274661

COMPLETED Phase 1 52 participants

A Study to Evaluate NT219 Alone and in Combination with ERBITUX® (Cetuximab) in Adults with Advanced Solid Tumors and Head and Neck Cancer

TyrNovo

NCT04474470

COMPLETED Phase 1 41 participants

First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

Relay Therapeutics

NCT05759949

COMPLETED 27 participants

Cannabis Use in Cancer Patients

University of Colorado, Denver

NCT03617692

COMPLETED Phase 1 26 participants

A Study of DCR-STAT3 in Adults With Solid Tumors

Dicerna Pharmaceuticals, Inc., a Novo Nordisk company

NCT06098651

COMPLETED Phase 1 22 participants

Study of FCN-437c in Patients With Advanced Solid Tumors

Fochon Pharmaceuticals

NCT03951116

COMPLETED Phase 1 19 participants

18F-FDG Uptake Measurements in Malignant Solid Tumors on PET/CT and PET/MR

Washington University School of Medicine

NCT02717572

Phase Distribution

PhaseTrial count
Early Phase 1 57
Phase 2 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Solid Tumor, Adult Trial Landscape

ClinicalTrials.gov lists 73 US studies indexed under Solid Tumor, Adult, and 48 of those are currently open to recruitment — roughly 66% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Solid Tumor, Adult shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 61 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Solid Tumor, Adult is led by Memorial Sloan Kettering Cancer Center with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 73 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Solid Tumor, Adult?

PlainTrial tracks 73 US clinical trials for Solid Tumor, Adult, of which 48 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Solid Tumor, Adult?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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