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ClinicalTrials.gov 135 recruiting now official registry

Parkinson Disease clinical trials

135 of 298 indexed Parkinson Disease trials are currently recruiting.

298 US clinical trials · 135 currently recruiting

Parkinson Disease is the subject of 298 registered US clinical trials on ClinicalTrials.gov, 135 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 66 in Phase 1-2 (earlier-stage). The most active sponsor is University of Minnesota, running 10 of these trials.

The research picture

Parkinson Disease has 298 registered US clinical trials, 135 of them open to new participants right now, about 45% of the total.

135
recruiting participants now
45%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
10
top sponsor: University of Minnesota
Phase 131Phase 235Phase 38Phase 413

Active & Recent Trials

298 total, page 3 of 6

RECRUITING NA 32 participants

Exercise for Cognitive Excellence in Parkinson's Disease

University of California, San Francisco

NCT05720468

RECRUITING Early Phase 1 31 participants

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

Vanderbilt University Medical Center

NCT04620382

RECRUITING 30 participants

Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease

University of Alabama at Birmingham

NCT05482126

RECRUITING NA 30 participants

Vibrotactile Coordinated Reset: a Non-invasive Treatment for Parkinson's Disease 2

Synergic Medical Technologies

NCT05881460

RECRUITING NA 30 participants

Robotic Gait Rehabilitation in Parkinson's Disease

Indiana University

NCT05218187

RECRUITING NA 30 participants

User-friendliness of a Portable Driving Simulator

University of Kansas Medical Center

NCT03969927

RECRUITING 30 participants

Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst

University of Minnesota

NCT05658302

RECRUITING NA 25 participants

Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.

University of Minnesota

NCT06692920

RECRUITING 25 participants

The GBA Multimodal Study in Parkinson's Disease

Pacific Parkinson's Research Centre

NCT04101968

RECRUITING Phase 4 25 participants

Personalized Real-Time DBS and PD Mechanisms

David Escobar

NCT06013956

RECRUITING NA 24 participants

Unlocking Movement Potential: Enhancing Parkinson's Disease Treatment With Robotic EksoSkeleton

Albert Einstein Healthcare Network

NCT06225830

RECRUITING Phase 4 22 participants

BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease

The Cleveland Clinic

NCT07138560

RECRUITING 20 participants

Colonoscopic Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis

CND Life Sciences

NCT07204652

RECRUITING NA 20 participants

Imaging Core Aim 2, and Udall Project 2 Aim 2

University of Minnesota

NCT06998303

RECRUITING NA 20 participants

Effects Of Osteopathic Manipulative Medicine(OMM) On Lower Extremity Muscle Characteristics In Parkinson's Disease(PD) Patients

New York Institute of Technology

NCT05884944

RECRUITING NA 20 participants

rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease

West Virginia University

NCT06237868

RECRUITING NA 20 participants

Light Therapy Intervention in Individuals With Parkinson's Disease

University of Delaware

NCT06916260

RECRUITING NA 20 participants

Spinal Cord Stimulation for Parkinson's Disease Rehabilitation

University of Louisville

NCT06804642

RECRUITING NA 20 participants

Effects of Transcranial Ultrasound Stimulation (TUS) on Neurological and Cognitive Outcomes in Neurodegenerative Diseases

Sanmai Technologies PBC dba Sanmai

NCT07207122

RECRUITING NA 20 participants

Real-Time Levodopa Level Monitoring in Parkinson Disease

University of California, San Diego

NCT04735627

RECRUITING Phase 1 18 participants

A Study to Assess the Safety of BMS-984923 Compared to Placebo, in People With Parkinson's

Allyx Therapeutics

NCT06309147

RECRUITING Phase 2 16 participants

Pyridostigmine for the Treatment of Constipation in Parkinson Disease

University of Vermont Medical Center

NCT05603715

RECRUITING NA 16 participants

Endurance Exercise & Virtual Reality for Optimizing Cortical Excitability and Neuroplasticity in PD

The University of Texas Health Science Center at San Antonio

NCT06133283

RECRUITING NA 15 participants

Neocortical Microarchitecture of Executive Function

University of Colorado, Denver

NCT06778135

RECRUITING NA 15 participants

SegwayPD: The Effect of Sensory-augmented Postural Training Using Segway on Motor and Cognitive Function in Individuals With Parkinson's Disease

University of Texas Southwestern Medical Center

NCT05982730

RECRUITING 15 participants

Naturalistic Sleep Assessed by Wearable Devices in Parkinson Disease

University of Colorado, Denver

NCT05348837

RECRUITING NA 12 participants

Correlation of STN-DBS Induced Visuospatial Changes and Freezing of Gait

Medical University of South Carolina

NCT06994728

RECRUITING NA 10 participants

Effects of RAS on Gait in PD Patients With DBS

Johns Hopkins University

NCT05763732

RECRUITING NA 10 participants

Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease

The Cleveland Clinic

NCT07110376

RECRUITING 10 participants

Adaptive DBS to Offset STN Dysregulation During Exercise in PD

University of Colorado, Denver

NCT06296810

RECRUITING NA 10 participants

Globus Pallidus Stimulation to Treat Insomnia

Mayo Clinic

NCT04116996

RECRUITING NA 10 participants

Dual Frequency Stimulation in Parkinson's Disease

University of California, Davis

NCT04650932

RECRUITING Phase 1 8 participants

Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons

Jeffrey S. Schweitzer, MD, PhD

NCT06687837

RECRUITING NA 6 participants

Safety and Feasibility of Tele-supervised Home-based Transcranial Direct Current Stimulation in Parkinson's Disease

Brigham and Women's Hospital

NCT06804668

RECRUITING Phase 1 5 participants

This Clinical Trial is Designed to Evaluate the Safety, Tolerability, Feasibility and Preliminary Efficacy of NouvNeu001 (Human Dopaminergic Progenitor Cells Injection) in Patients With Parkinson's Disease.

iRegene Therapeutics Co.

NCT07102342

ACTIVE NOT RECRUITING NA 20,000 participants

Mobile Parkinson Observatory for Worldwide, Evidence-based Research (mPower)

Sage Bionetworks

NCT02696603

ACTIVE NOT RECRUITING Phase 4 2,650 participants

Trial of Parkinson's And Zoledronic Acid

California Pacific Medical Center Research Institute

NCT03924414

ACTIVE NOT RECRUITING Phase 2 650 participants

A Study to Learn About the Safety of BIIB122 Tablets and Whether They Can Slow the Worsening of Early-Stage Parkinson's Disease in Adults Between the Ages of 30 and 80

Biogen

NCT05348785

ACTIVE NOT RECRUITING NA 632 participants

Community Outreach for Palliative Engagement -- Parkinson Disease

University of Rochester

NCT05222386

ACTIVE NOT RECRUITING NA 350 participants

DB RCT for Specialized Phototherapy in Parkinson's Disease.

PhotoPharmics

NCT04453033

ACTIVE NOT RECRUITING 315 participants

Automated Imaging Differentiation of Parkinsonism

University of Florida

NCT05913687

ACTIVE NOT RECRUITING Phase 2 314 participants

A Study to Evaluate Safety and Efficacy of KM-819 in Healthy Adults and Participants with Parkinson's Disease

FAScinate Therapeutics

NCT05670782

ACTIVE NOT RECRUITING 257 participants

Personalizing Exercise for Parkinson Disease

Washington University School of Medicine

NCT04782518

ACTIVE NOT RECRUITING NA 231 participants

Evaluation of the Personal KinetiGraph™ (PKG™) to Improve Insight Into Parkinson's Disease Status

Global Kinetics Corporation

NCT03741920

ACTIVE NOT RECRUITING NA 200 participants

Wearable Airbag Technology to Mitigate Falls in Individuals With High Fall Risk

Shirley Ryan AbilityLab

NCT05076565

ACTIVE NOT RECRUITING NA 160 participants

Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

Vanderbilt University Medical Center

NCT05933681

ACTIVE NOT RECRUITING Early Phase 1 140 participants

Quantitative Imaging of Brain Glymphatic Function in Humans

Vanderbilt University Medical Center

NCT04768101

ACTIVE NOT RECRUITING NA 125 participants

Cholinergic Mechanisms of Attentional-motor Integration and Gait Dysfunction in Parkinson Disease (UDALL)

University of Michigan

NCT05459753

ACTIVE NOT RECRUITING NA 120 participants

Everyday Memory Impairment in PD-related Cognitive Decline

Washington University School of Medicine

NCT04474379

ACTIVE NOT RECRUITING 100 participants

Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease

CND Life Sciences

NCT06621602

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Reading the Parkinson Disease Trial Landscape

298 indexed Parkinson Disease studies · 135 recruiting (45%).

Phase mix: 21 late (III/IV) vs 66 early (I/II).

Top sponsor: University of Minnesota (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Parkinson Disease?

PlainTrial tracks 298 US clinical trials for Parkinson Disease, of which 135 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Parkinson Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.