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ClinicalTrials.gov 135 recruiting now official registry

Parkinson Disease clinical trials

135 of 298 indexed Parkinson Disease trials are currently recruiting.

298 US clinical trials · 135 currently recruiting

Parkinson Disease is the subject of 298 registered US clinical trials on ClinicalTrials.gov, 135 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 66 in Phase 1-2 (earlier-stage). The most active sponsor is University of Minnesota, running 10 of these trials.

The research picture

Parkinson Disease has 298 registered US clinical trials, 135 of them open to new participants right now, about 45% of the total.

135
recruiting participants now
45%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
10
top sponsor: University of Minnesota
Phase 131Phase 235Phase 38Phase 413

Active & Recent Trials

298 total, page 2 of 6

RECRUITING 80 participants

Cognitive Decline Following Deep Brain Stimulation

Medical University of South Carolina

NCT05822388

RECRUITING NA 80 participants

Cortical-Basal Ganglia Speech Networks

Massachusetts General Hospital

NCT04286308

RECRUITING NA 75 participants

Neurophysiology of Reward Signaling in Parkinson's Disease

Vanderbilt University Medical Center

NCT07409207

RECRUITING NA 75 participants

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Vanderbilt University Medical Center

NCT04715984

RECRUITING NA 75 participants

Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease

University of Minnesota

NCT06506058

RECRUITING Phase 4 75 participants

Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases

Vanderbilt University Medical Center

NCT05357612

RECRUITING NA 70 participants

Understanding Motivation in Parkinson's Patients Through Neurophysiology

University of California, San Francisco

NCT05065151

RECRUITING NA 64 participants

High-intensity Interval Circuit Training in People With Parkinson Disease

Pacific Northwest University of Health Sciences

NCT06576817

RECRUITING 60 participants

Parkinson's Disease Biomarkers in Nerve Cells in the Gut

Weill Medical College of Cornell University

NCT05347407

RECRUITING Early Phase 1 60 participants

Multiple Objective Particle Swarm Optimization Postural Instability Gait Disorder

University of Minnesota

NCT05893186

RECRUITING NA 60 participants

Cortical Correlates of Gait in Parkinson's Disease: Impact of Medication and Cueing

Oregon Health and Science University

NCT05818189

RECRUITING NA 60 participants

Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder

University of Minnesota

NCT06467461

RECRUITING Phase 2 60 participants

Psilocybin Therapy for Depression in Parkinson's Disease

Joshua Woolley, MD, PhD

NCT06455293

RECRUITING NA 60 participants

TURN-IT FOG: Improving Turning and Freezing of Gait in People With PD

Oregon Health and Science University

NCT06815302

RECRUITING NA 60 participants

Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control

Jorge Gonzalez-Martinez

NCT07056361

RECRUITING NA 60 participants

10,000 Step Club: Community Walking Program for People with Parkinson's Disease

University of Nevada, Las Vegas

NCT06605183

RECRUITING NA 60 participants

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

University of Florida

NCT06911229

RECRUITING 60 participants

Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor

Vanderbilt University Medical Center

NCT01734122

RECRUITING NA 60 participants

Dance and Energy Expenditure Among Adults With Parkinson's

Northeastern University

NCT06425731

RECRUITING NA 60 participants

Virtual Cycling Environments for Persons With Parkinson Disease

Rutgers, The State University of New Jersey

NCT04804202

RECRUITING 60 participants

Drug Discovery for Parkinson's With Mutations in the GBA Gene

New York Stem Cell Foundation Research Institute

NCT05536388

RECRUITING NA 60 participants

Blood Pressure Effects on Cognition and Brain Blood Flow in PD

University of California, San Diego

NCT05400174

RECRUITING NA 60 participants

Apathy in Parkinson Disease TMS Study

University of North Carolina, Chapel Hill

NCT06087926

RECRUITING Phase 3 60 participants

A Digital Therapeutic Platform for Swallowing and Drooling Problems in Parkinson's

Northwestern University

NCT04664634

RECRUITING Early Phase 1 60 participants

Longitudinal TSPO PET Imaging With [18F]DPA-714 in PPMI (PPMI DPA-714 PET Imaging)

University of Alabama at Birmingham

NCT06289582

RECRUITING NA 59 participants

CPAP for the Treatment of Supine Hypertension

Vanderbilt University Medical Center

NCT05489575

RECRUITING Phase 2 56 participants

Intranasal Insulin and Glutathione as an Add-On Therapy in Parkinson's Disease

Gateway Institute for Brain Research

NCT05266417

RECRUITING 55 participants

Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study

Medical University of South Carolina

NCT06960096

RECRUITING Phase 1 54 participants

First-in-Human Single and Multiple Dose of HL-400

Highlightll Pharmaceutical (USA)

NCT06997484

RECRUITING Early Phase 1 50 participants

Title: A Multimodal Exercise Program With Gamification for Parkinson Disease (MEP+G)

California State University, Northridge

NCT06538298

RECRUITING 50 participants

Neuroplasticity in Parkinson's Disease

University of Minnesota

NCT05286736

RECRUITING Phase 2 50 participants

Safety and Pharmacodynamic Effects of BIIB122 in Participants With LRRK2-Associated Parkinson's Disease (LRRK2-PD)

Denali Therapeutics

NCT06602193

RECRUITING NA 50 participants

Action Regulation Behavioral

University of Texas Southwestern Medical Center

NCT06489483

RECRUITING Phase 1 45 participants

Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments

Prabesh Kanel

NCT07154511

RECRUITING NA 45 participants

Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease

University of North Carolina, Chapel Hill

NCT05864157

RECRUITING NA 42 participants

Evaluation of a Decision Aid for Deep Brain Stimulation Surgery for Parkinson's Disease

University of Colorado, Denver

NCT06446505

RECRUITING Early Phase 1 42 participants

Noise-augmented Automatic Speech Recognition for Speech Treatment in Parkinson's Disease

Teachers College, Columbia University

NCT06540989

RECRUITING NA 41 participants

Use of CereGate Therapy for Freezing of Gait in PD

CereGate

NCT05292794

RECRUITING NA 40 participants

Effects of an Independent Walking Program With Walking Poles in People With Parkinson Disease

Pacific Northwest University of Health Sciences

NCT06908135

RECRUITING NA 40 participants

Occupational Therapy Led Social Prescription for People With Parkinson Disease

Colorado State University

NCT06447207

RECRUITING Phase 1 40 participants

[18F]F-DOPA Imaging in Patients With Autonomic Failure

Daniel Claassen

NCT04246437

RECRUITING 40 participants

Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder

CND Life Sciences

NCT07217054

RECRUITING NA 40 participants

Step Up to PD: A Community-based Walking Program for People With Parkinson's Disease

St. Louis University

NCT06859528

RECRUITING NA 40 participants

Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation

University of Southern California

NCT05307055

RECRUITING NA 40 participants

High Frequency Light, Sound, and Tactile Stimulation to Improve Motor and Cognitive Deficits in Parkinson's Disease

Massachusetts Institute of Technology

NCT05268887

RECRUITING NA 36 participants

Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD

University of Alabama at Birmingham

NCT06169852

RECRUITING 36 participants

Udall Project 2 Aim 2A&C

University of Minnesota

NCT05656586

RECRUITING NA 36 participants

Percept Transitions in FOG and PD

University of Minnesota

NCT06848205

RECRUITING Phase 1 34 participants

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Vanderbilt University Medical Center

NCT02897063

RECRUITING NA 32 participants

Dysarthria Management for Minor Groups

Florida State University

NCT06593860

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Reading the Parkinson Disease Trial Landscape

298 indexed Parkinson Disease studies · 135 recruiting (45%).

Phase mix: 21 late (III/IV) vs 66 early (I/II).

Top sponsor: University of Minnesota (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Parkinson Disease?

PlainTrial tracks 298 US clinical trials for Parkinson Disease, of which 135 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Parkinson Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.