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Parkinson Disease clinical trials
135 of 298 indexed Parkinson Disease trials are currently recruiting.
298 US clinical trials · 135 currently recruiting
Parkinson Disease is the subject of 298 registered US clinical trials on ClinicalTrials.gov, 135 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 66 in Phase 1-2 (earlier-stage). The most active sponsor is University of Minnesota, running 10 of these trials.
The research picture
Parkinson Disease has 298 registered US clinical trials, 135 of them open to new participants right now, about 45% of the total.
- 135
- recruiting participants now
- 45%
- of trials open to enrollment
- 21
- in Phase 3–4 (later-stage)
- 10
- top sponsor: University of Minnesota
Active & Recent Trials
298 total, page 2 of 6
Cognitive Decline Following Deep Brain Stimulation
Medical University of South Carolina
NCT05822388
Cortical-Basal Ganglia Speech Networks
Massachusetts General Hospital
NCT04286308
Neurophysiology of Reward Signaling in Parkinson's Disease
Vanderbilt University Medical Center
NCT07409207
Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment
Vanderbilt University Medical Center
NCT04715984
Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease
University of Minnesota
NCT06506058
Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases
Vanderbilt University Medical Center
NCT05357612
Understanding Motivation in Parkinson's Patients Through Neurophysiology
University of California, San Francisco
NCT05065151
High-intensity Interval Circuit Training in People With Parkinson Disease
Pacific Northwest University of Health Sciences
NCT06576817
Parkinson's Disease Biomarkers in Nerve Cells in the Gut
Weill Medical College of Cornell University
NCT05347407
Multiple Objective Particle Swarm Optimization Postural Instability Gait Disorder
University of Minnesota
NCT05893186
Cortical Correlates of Gait in Parkinson's Disease: Impact of Medication and Cueing
Oregon Health and Science University
NCT05818189
Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder
University of Minnesota
NCT06467461
Psilocybin Therapy for Depression in Parkinson's Disease
Joshua Woolley, MD, PhD
NCT06455293
TURN-IT FOG: Improving Turning and Freezing of Gait in People With PD
Oregon Health and Science University
NCT06815302
Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control
Jorge Gonzalez-Martinez
NCT07056361
10,000 Step Club: Community Walking Program for People with Parkinson's Disease
University of Nevada, Las Vegas
NCT06605183
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
University of Florida
NCT06911229
Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
Vanderbilt University Medical Center
NCT01734122
Dance and Energy Expenditure Among Adults With Parkinson's
Northeastern University
NCT06425731
Virtual Cycling Environments for Persons With Parkinson Disease
Rutgers, The State University of New Jersey
NCT04804202
Drug Discovery for Parkinson's With Mutations in the GBA Gene
New York Stem Cell Foundation Research Institute
NCT05536388
Blood Pressure Effects on Cognition and Brain Blood Flow in PD
University of California, San Diego
NCT05400174
Apathy in Parkinson Disease TMS Study
University of North Carolina, Chapel Hill
NCT06087926
A Digital Therapeutic Platform for Swallowing and Drooling Problems in Parkinson's
Northwestern University
NCT04664634
Longitudinal TSPO PET Imaging With [18F]DPA-714 in PPMI (PPMI DPA-714 PET Imaging)
University of Alabama at Birmingham
NCT06289582
CPAP for the Treatment of Supine Hypertension
Vanderbilt University Medical Center
NCT05489575
Intranasal Insulin and Glutathione as an Add-On Therapy in Parkinson's Disease
Gateway Institute for Brain Research
NCT05266417
Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study
Medical University of South Carolina
NCT06960096
First-in-Human Single and Multiple Dose of HL-400
Highlightll Pharmaceutical (USA)
NCT06997484
Title: A Multimodal Exercise Program With Gamification for Parkinson Disease (MEP+G)
California State University, Northridge
NCT06538298
Neuroplasticity in Parkinson's Disease
University of Minnesota
NCT05286736
Safety and Pharmacodynamic Effects of BIIB122 in Participants With LRRK2-Associated Parkinson's Disease (LRRK2-PD)
Denali Therapeutics
NCT06602193
Action Regulation Behavioral
University of Texas Southwestern Medical Center
NCT06489483
Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments
Prabesh Kanel
NCT07154511
Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease
University of North Carolina, Chapel Hill
NCT05864157
Evaluation of a Decision Aid for Deep Brain Stimulation Surgery for Parkinson's Disease
University of Colorado, Denver
NCT06446505
Noise-augmented Automatic Speech Recognition for Speech Treatment in Parkinson's Disease
Teachers College, Columbia University
NCT06540989
Use of CereGate Therapy for Freezing of Gait in PD
CereGate
NCT05292794
Effects of an Independent Walking Program With Walking Poles in People With Parkinson Disease
Pacific Northwest University of Health Sciences
NCT06908135
Occupational Therapy Led Social Prescription for People With Parkinson Disease
Colorado State University
NCT06447207
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Daniel Claassen
NCT04246437
Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder
CND Life Sciences
NCT07217054
Step Up to PD: A Community-based Walking Program for People With Parkinson's Disease
St. Louis University
NCT06859528
Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation
University of Southern California
NCT05307055
High Frequency Light, Sound, and Tactile Stimulation to Improve Motor and Cognitive Deficits in Parkinson's Disease
Massachusetts Institute of Technology
NCT05268887
Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD
University of Alabama at Birmingham
NCT06169852
Udall Project 2 Aim 2A&C
University of Minnesota
NCT05656586
Percept Transitions in FOG and PD
University of Minnesota
NCT06848205
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
Vanderbilt University Medical Center
NCT02897063
Dysarthria Management for Minor Groups
Florida State University
NCT06593860
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 31 |
| Phase 2 | 35 |
| Phase 3 | 8 |
| Phase 4 | 13 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Parkinson Disease Trial Landscape
298 indexed Parkinson Disease studies · 135 recruiting (45%).
Phase mix: 21 late (III/IV) vs 66 early (I/II).
Top sponsor: University of Minnesota (10 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Parkinson Disease?
PlainTrial tracks 298 US clinical trials for Parkinson Disease, of which 135 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Parkinson Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.