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ClinicalTrials.gov 135 recruiting now official registry

Parkinson Disease clinical trials

135 of 298 indexed Parkinson Disease trials are currently recruiting.

298 US clinical trials · 135 currently recruiting

Parkinson Disease is the subject of 298 registered US clinical trials on ClinicalTrials.gov, 135 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 66 in Phase 1-2 (earlier-stage). The most active sponsor is University of Minnesota, running 10 of these trials.

The research picture

Parkinson Disease has 298 registered US clinical trials, 135 of them open to new participants right now, about 45% of the total.

135
recruiting participants now
45%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
10
top sponsor: University of Minnesota
Phase 131Phase 235Phase 38Phase 413

Active & Recent Trials

298 total, page 4 of 6

ACTIVE NOT RECRUITING NA 100 participants

Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation

Abbott Medical Devices

NCT05269862

ACTIVE NOT RECRUITING Phase 1 100 participants

Promoting Physical Activity Engagement for People With Early-mid Stage Parkinson's Disease (Engage-PD)

Teachers College, Columbia University

NCT04922190

ACTIVE NOT RECRUITING Phase 2 99 participants

NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)

Aptinyx

NCT04148391

ACTIVE NOT RECRUITING 94 participants

Neuro-immune Interactome in Parkinson's Disease

Yale University

NCT07026929

ACTIVE NOT RECRUITING NA 92 participants

ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease

InSightec

NCT03319485

ACTIVE NOT RECRUITING NA 90 participants

Non-invasive Brain Mapping of Movement Facilitation in Parkinson's Disease

University of California, Los Angeles

NCT05179187

ACTIVE NOT RECRUITING 85 participants

Remote Monitoring in Progressive Supranuclear Palsy (PSP)

Massachusetts General Hospital

NCT04753320

ACTIVE NOT RECRUITING 82 participants

Parkinson's Disease Progression Study

Koneksa Health

NCT06219629

ACTIVE NOT RECRUITING Phase 2 74 participants

Sing For Your Saunter Part 2 R33

Washington University School of Medicine

NCT06115382

ACTIVE NOT RECRUITING NA 60 participants

Home Based Tele-exercise for People With Chronic Neurological Impairments

Burke Medical Research Institute

NCT04564495

ACTIVE NOT RECRUITING NA 55 participants

Mobility in Daily Life and Falls in Parkinson's Disease: Potential for Rehabilitation

Oregon Health and Science University

NCT04897256

ACTIVE NOT RECRUITING Phase 2 50 participants

FDOPA PET and Nutritional Support in Parkinson's Disease

Thomas Jefferson University

NCT04459052

ACTIVE NOT RECRUITING NA 50 participants

Evaluation of the Safety and Effectiveness of Bilateral Exablate Ablation of the Pallidothalamic Tract (PTT) for the Treatment of the Motor Complications of Parkinson's Disease (PD)

InSightec

NCT04728295

ACTIVE NOT RECRUITING 50 participants

Early Longitudinal Imaging in Parkinson's Progression Markers Initiative Using [¹⁸F] AV-133 and DaTscan™

Michael J. Fox Foundation for Parkinson's Research

NCT04507139

ACTIVE NOT RECRUITING NA 40 participants

Transcranial Direct Current Stimulation for Cognitive Improvement in Parkinson's Patients

Sanford Health

NCT03191916

ACTIVE NOT RECRUITING NA 40 participants

RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson's Disease

University of Alabama at Birmingham

NCT03305588

ACTIVE NOT RECRUITING NA 40 participants

Parkinson's Disease: Enhancing Physical Therapy With Brain Stimulation for Treating Postural Instability.

Spaulding Rehabilitation Hospital

NCT03981055

ACTIVE NOT RECRUITING 40 participants

Functional Neuroimaging in Parkinson's Disease

University of Delaware

NCT04904068

ACTIVE NOT RECRUITING Phase 1 32 participants

Phase 1/2a Clinical Trial of PR001 (LY3884961) in Patients With Parkinson's Disease With at Least One GBA1 Mutation (PROPEL)

Prevail Therapeutics

NCT04127578

ACTIVE NOT RECRUITING Phase 2 30 participants

Resistant Maltodextrin for Gut Microbiome in Parkinson's Disease: Safety and Tolerability Study

Northwestern University

NCT03667404

ACTIVE NOT RECRUITING NA 25 participants

The Motor Network in Parkinson's Disease and Dystonia: Mechanisms of Therapy

University of California, San Francisco

NCT03582891

ACTIVE NOT RECRUITING NA 24 participants

Gamma Sensory Flicker for Parkinson's Disease Patients With Freezing of Gait

Emory University

NCT06295458

ACTIVE NOT RECRUITING Phase 1 20 participants

Repurposing Lithium for Parkinson's Disease: a RCT

State University of New York at Buffalo

NCT06339034

ACTIVE NOT RECRUITING NA 20 participants

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease

University of Nebraska

NCT04620551

ACTIVE NOT RECRUITING 15 participants

Subcortical Oscillations in Human Sleep Dysregulation

University of Colorado, Denver

NCT03377569

ACTIVE NOT RECRUITING Phase 1 12 participants

Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease

James Liao

NCT05022147

ACTIVE NOT RECRUITING Early Phase 1 11 participants

Evaluation of Neuroinflammation in Parkinson's Disease Using 18F-NOS PET/CT

University of Pennsylvania

NCT04062526

ACTIVE NOT RECRUITING NA 10 participants

Adaptive Deep Brain Stimulation to Improve Motor and Gait Functions in Parkinson's Disease

Doris Wang, MD, PhD

NCT04675398

ACTIVE NOT RECRUITING NA 10 participants

HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH)-Parkinson's Disease (HOBSCOTCH-Parkinson's)

Dartmouth-Hitchcock Medical Center

NCT06260228

ACTIVE NOT RECRUITING NA 4 participants

Blood Flow Restriction and Exercise in Parkinson's Disease

University of California, San Francisco

NCT07221994

COMPLETED 3,234 participants

Impulse Control Disorders in Parkinson's Patients Treated With Pramipexole and Other Agents (DOMINION Study)

Boehringer Ingelheim

NCT00617019

COMPLETED 2,033 participants

Parkinson's Disease in African American and Caucasian Patients

University of Chicago

NCT03279445

COMPLETED Phase 3 600 participants

Study Evaluating Sumanirole for the Treatment of the Signs and Symptoms of Early Parkinson's Disease.

Pfizer

NCT00036218

COMPLETED Phase 3 544 participants

A Phase 3 Study With P2B001 in Subjects With Early Parkinson's

Pharma Two B

NCT03329508

COMPLETED 485 participants

Speech Accessibility Project

University of Illinois at Urbana-Champaign

NCT05889260

COMPLETED 456 participants

Physiological Brain Atlas Development

Ohio State University

NCT01210534

COMPLETED 428 participants

Synuclein-One Study

CND Life Sciences

NCT04700722

COMPLETED Phase 3 419 participants

An Open-label Continuation Study Evaluating the Long-term Safety of Extended Release Ropinirole XL (Formerly CR) in Parkinson''s Disease

GlaxoSmithKline

NCT00632736

COMPLETED Phase 4 352 participants

A Fixed Dose Study of Ropinirole Prolonged Release as Adjunctive Treatment in Patients With Advanced Parkinson's Disease

GlaxoSmithKline

NCT01494532

COMPLETED Phase 3 304 participants

Flexible-Dose Trial in Early Parkinson's Disease (PD)

AbbVie

NCT04223193

COMPLETED 242 participants

PET Study of Non-Motor Symptoms of Parkinson Disease

University of Michigan

NCT01565473

COMPLETED 239 participants

Opicapone Treatment Initiation Open-Label Study

Neurocrine Biosciences

NCT04787965

COMPLETED NA 203 participants

Light Therapy for PD - Dose Selection

Massachusetts General Hospital

NCT04291014

COMPLETED Phase 2 195 participants

NINDS Parkinson's Disease Neuroprotection Trial of CoQ10 and GPI 1485

University of Rochester

NCT00076492

COMPLETED NA 188 participants

STEM-Parkinson's Disease

Scion NeuroStim

NCT04797611

COMPLETED Phase 2 151 participants

Orally Administered ENT-01 for Parkinson's Disease-Related Constipation (KARMET)

Enterin

NCT03781791

COMPLETED 146 participants

Social Self-Management of Parkinson's Disease

Tufts University

NCT03938974

COMPLETED 140 participants

FoxBioNet: ECV (Extracellular Vesicle) 004

Michael J. Fox Foundation for Parkinson's Research

NCT04603326

COMPLETED 133 participants

How the Loss of Dopamine and Dopamine-Restoring Medicines Affect Movement Performance

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00040196

COMPLETED 132 participants

Wearable Assessments in the Clinic and Home in PD

University of Rochester

NCT03681015

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Reading the Parkinson Disease Trial Landscape

298 indexed Parkinson Disease studies · 135 recruiting (45%).

Phase mix: 21 late (III/IV) vs 66 early (I/II).

Top sponsor: University of Minnesota (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Parkinson Disease?

PlainTrial tracks 298 US clinical trials for Parkinson Disease, of which 135 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Parkinson Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.